Mikospor Set - Instructions For Use, Price, Reviews, Analogues

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Mikospor Set - Instructions For Use, Price, Reviews, Analogues
Mikospor Set - Instructions For Use, Price, Reviews, Analogues

Video: Mikospor Set - Instructions For Use, Price, Reviews, Analogues

Video: Mikospor Set - Instructions For Use, Price, Reviews, Analogues
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Mycospore set

Mikospor set: instructions for use and reviews

  1. 1. Release form and composition
  2. 2. Pharmacological properties
  3. 3. Indications for use
  4. 4. Contraindications
  5. 5. Method of application and dosage
  6. 6. Side effects
  7. 7. Overdose
  8. 8. Special instructions
  1. 9. Application during pregnancy and lactation
  2. 10. Use in childhood
  3. 11. Drug interactions
  4. 12. Analogs
  5. 13. Terms and conditions of storage
  6. 14. Terms of dispensing from pharmacies
  7. 15. Reviews
  8. 16. Price of boron in pharmacies

Latin name: Mycospor onychoset

ATX code: D01AC60

Active ingredient: Bifonazole + Urea (Bifonazole + Urea)

Producer: Bayer Pharma AG (Germany)

Description and photo update: 2018-25-10

Ointment for external use Mikospor set
Ointment for external use Mikospor set

Mikospor set is a combined antifungal agent for external use.

Release form and composition

Dosage form - ointment for external use: uniform consistency, white with a yellowish tinge color (10 g in aluminum tubes, 1 tube in a cardboard box. The set also includes a package of waterproof plaster, a scraper and a dispenser for the ointment).

Composition of 1 g of ointment:

  • active substances: urea - 400 mg, bifonazole - 10 mg;
  • auxiliary components: white petrolatum, white beeswax, lanolin.

Pharmacological properties


The action of the Mycospores set is due to the active substances included in the ointment.

Urea has a keratoplastic effect: it softens the keratin of the infected nail plate, thereby increasing the penetration depth of the second active substance, bifonazole, which has antifungal properties.

Bifonazole is an imidazole derivative with a broad spectrum of antimycotic action. The drug inhibits ergosterol biosynthesis at two different levels, which differs from other azole derivatives and antifungal agents. Due to this double action, structural and functional damage to the cytoplasmic membrane of the fungus occurs.

In relation to dermatophytes (in particular, Trichophyton spp.), Bifonazole has a fungicidal effect (achieved at a substance concentration of 5 μg / ml and a duration of exposure of at least 6 hours).

Bifonazole has fungistatic activity against Malassezia furfur, mold and yeast (including Candida species) fungi. In the case of yeast infection, bifonazole at a concentration of 1–4 μg / ml has a predominantly fungistatic effect. For a fungicidal effect, a concentration of 20 μg / ml is required.

Also, the drug is active against gram-positive cocci, with the exception of enterococci (MIC * 4-16 μg / ml), and Corynebacterium minutissimum (MIC from 0.5 to 2 μg / ml).

* MIC is the minimum concentration of bifonazole that suppresses the growth of a microorganism.

Strains of fungi that are resistant to the drug are extremely rare. According to the data of clinical studies, secondary resistance does not develop in primary susceptible strains.

The use of bifonazole in combination with urea enhances the antimycotic effect of Mikospor kit.


When the ointment is applied externally, the absorption of the drug is 2–4% of the applied dose. In the treatment of lesions of the nail plate, the concentration of bifonazole in the blood plasma is always below the detection limit (i.e., less than 1 ng / ml), therefore no systemic effects occur.

In studies on rats, it was found that bifonazole crosses the placental barrier.

Indications for use

Mikospor set is intended for the treatment of onychomycosis, including the non-surgical removal of the affected nails on the hands and feet.


  • I trimester of pregnancy;
  • lactation period;
  • hypersensitivity to any component of the drug.

With caution, Mikospor set should be used in the following cases:

  • II and III trimesters of pregnancy;
  • childhood;
  • hypersensitivity to other antifungal agents from the group of imidazole derivatives (for example, to miconazole, clotrimazole, econazole).

Instructions for use of Mikospor kit: method and dosage

The drug is intended for external use.

The ointment should be applied to infected nails once a day so that it covers the entire surface of the nail plate in a thin layer. Each nail must be sealed with the included plaster and left in the bandage for 24 hours. After a day, the plasters are removed, the nails are kept in warm water for about 10 minutes, after which the softened part of each infected nail is removed with a scraper included in the set. At the end of the procedure, the nails are well dried, the ointment is again applied and sealed with a plaster.

When applying the ointment, be careful not to let it come into contact with the skin adjacent to the nail to avoid irritation. If signs of irritation appear, apply a cream containing zinc to the skin around the nail before applying a new patch.

Dressings should be changed every day. The duration of therapy is individual. Treatment must be continued until the softened nail plate is removed - this indicates its defeat by the fungus. Depending on the thickness of the nail and the degree of fungal infection, this takes 7 to 14 days. As soon as the affected part of the nail is completely removed, and the nail bed becomes smooth, the treatment is continued with a cream for external use Mikospor: it is applied to the nail bed 1 time a day for 4 weeks.

If no improvement is observed or the condition worsens within 7 days of using Mikospor kit, you should consult a dermatologist.

Side effects

During the use of Mikospor kit, the following side effects from the skin and subcutaneous tissues may be observed: impaired nail pigmentation, itching, skin irritation, rash (including allergic ones), erythema, desquamation, maceration, contact dermatitis, pain at the site of application and in limbs, damage to the nails and the nail bed (splitting of the nail plate, redness, irritation of the nail bed). These effects are reversible and disappear after drug withdrawal.


Since Mikospor set is used to treat fungal nail infections, overdose is unlikely after a single application of the ointment to the skin. If the drug is accidentally swallowed, the likelihood of overdose symptoms is also extremely low.

special instructions

Avoid getting the ointment in the eyes.

Do not take the drug internally.

Influence on the ability to drive vehicles and complex mechanisms

According to the instructions, Mikospor kit does not adversely affect the speed of reactions and the ability to concentrate.

Application during pregnancy and lactation

According to the data of preclinical and pharmacological studies, the active substances of the Mikospor kit do not have a negative effect on either the mother's body or the fetus. Controlled studies of the use of the drug in pregnant women have not been conducted, and therefore it is recommended to observe precautions: do not prescribe the drug in the first trimester, use it with caution and after assessing the balance of benefits and risks in the second and third trimesters.

It is not known whether the active ingredients of the Mycospore kit penetrate into breast milk in women. In experimental studies on animals, it was found that bifonazole is excreted in breast milk. In this regard, it is recommended to stop breastfeeding if therapy is required during lactation.

In the course of preclinical studies, data were obtained that suggest that bifonazole does not have a negative effect on female and male fertility. Urea is not harmful to sperm, but there is no information on the effect on female fertility.

Pediatric use

Caution should be exercised when treating children with the drug.

Drug interactions

There is limited evidence that the use of bifonazole (topically) simultaneously with warfarin can lead to an increase in the international normalized ratio, cause the development of bleeding and bruising. In this regard, patients receiving warfarin, during antifungal therapy using Mikospor kit, should be under close medical supervision.


The analogue of the Mikospor kit is Mikospor.

Terms and conditions of storage

Shelf life - no more than 3 years, subject to the manufacturer's recommended storage temperature - no more than 30 ° C.

Keep out of the reach of children.

Terms of dispensing from pharmacies

Available without a prescription.

Reviews of Mikospor set

Reviews of Mikospor set are controversial. Some patients confirm its high efficiency and write that it was with the help of this drug that they were able to cure nail fungus. Others, on the other hand, describe the remedy as ineffective and unnecessarily expensive. Some patients believe that the supplied cream dispenser and scraper are not convenient to use, and the plaster “does not work” - it is weakly attached and flies off all the time.

Price for Mikospor set in pharmacies

The price for Mikospor set is about 1145 rubles.

Anna Kozlova
Anna Kozlova

Anna Kozlova Medical journalist About the author

Education: Rostov State Medical University, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!

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