Latran
Instructions for use:
- 1. Release form and composition
- 2. Indications for use
- 3. Contraindications
- 4. Method of application and dosage
- 5. Side effects
- 6. Special instructions
- 7. Drug interactions
- 8. Analogs
- 9. Terms and conditions of storage
- 10. Terms of dispensing from pharmacies
Prices in online pharmacies:
from 138 rub.
Buy
Latran is a serotonin receptor antagonist; antiemetic, with anxiolytic activity, does not cause impaired coordination, sedation, decreased performance and activity.
Release form and composition
The drug is produced in the following dosage forms:
- Solution for intravenous and intramuscular administration: transparent liquid, almost colorless or colorless (2 ml or 4 ml in ampoules, in PVC (polyvinyl chloride) film 1, 2 or 5 ampoules, 1 cell in a cardboard box);
- Film-coated tablets: yellow shell (10 pcs. In a blister strip, 1 package in a cardboard box).
1 ml of solution contains:
- Active ingredient: ondansetron hydrochloride dihydrate (in terms of ondansetron) - 2 mg;
- Auxiliary components: hydrochloric acid, sodium chloride, water for injection.
1 coated tablet contains:
- Active ingredient: ondansetron hydrochloride dihydrate (in terms of ondansetron) - 4 mg;
- Auxiliary components: aerosil (colloidal silicon dioxide), microcrystalline cellulose, magnesium stearate, potato starch;
- Sheath: hydroxypropyl cellulose (hyprolose), tropeolin O, polysorbate (tween-80), castor oil.
Indications for use
Latran is indicated for use to prevent or eliminate nausea and vomiting in the following cases:
- Cytostatic chemotherapy, X-ray radiation therapy, other forms of radiation exposure;
- Postoperative period.
The drug is also used for the symptomatic treatment of mild to moderate alcohol withdrawal symptoms.
Contraindications
- Pregnancy;
- Lactation period (breastfeeding);
- Children under 2 years of age (the efficacy and safety of the drug in this age group has not been studied);
- Hypersensitivity to ondansetron and / or auxiliary components of the drug.
Method of administration and dosage
The solution is administered intramuscularly (i / m), intravenously (i / v) in a slow stream or drip. In one part of the body, intramuscular administration of Latran is allowed in a dose of not more than 4 mg.
The tablets are for oral administration.
The dosage regimen of Latran for cytostatic therapy depends on the emetogenicity of the antitumor procedure and the age category of the patient.
Moderate emetogenic chemotherapy or radiotherapy, adult patients: standard daily dose - 8-32 mg:
- Solution: immediately before the start of the procedure, intravenous jet slowly or intramuscularly - 8 mg;
- Tablets: 1-2 hours before the start of treatment, 2 pcs. 4 mg (8 mg), the next dose in the same dose 12 hours after the start of the course.
Highly emetogenic chemotherapy, adult patients:
- Intravenous jet slow infusion - 8 mg immediately before the start of the procedure, 2 more intravenous injections of 8 mg with an interval between them from 2 to 4 hours;
- Intravenous continuous drip infusion - during the day at a dose of 24 mg at a rate of 1 mg / hour;
- Intravenous 15-minute infusion, immediately before the start of the procedure - 16-32 mg, diluted in 50-100 ml of the corresponding infusion solution.
The effectiveness of Latran solution can be increased by a single intravenous injection of a glucocorticoid (for example, dexamethasone - 20 mg) before the start of chemotherapy. For oral administration, a single dose can be increased to 24 mg to enhance the effect, and at the same time prescribe 12 mg of dexamethasone (1-2 hours before the start of chemotherapy).
In order to prevent delayed vomiting, which occurs a day later (the first 24 hours) from the start of treatment, it is recommended to continue using Latran orally - 2 tablets of 4 mg (8 mg) 2 times a day for 5 days.
For children over 2 years of age, the drug is prescribed immediately before the start of chemotherapy, intravenously at a dose of 5 mg / m2 of body surface. After 12 hours, oral administration of the drug is recommended - 1 tablet (4 mg); at the end of chemotherapy, it is recommended to take 1 pill for 5 days. (With 4 mg) 2 times a day.
Prevention of nausea and vomiting in the postoperative period:
- Adults: a single dose of 4 mg IM or IV stream slowly at the beginning of anesthesia, or 16 mg (4 tablets) orally 1 hour before anesthesia;
- Children: exclusively in the form of a solution, slowly intravenously before or after anesthesia, a single dose of 0.1 mg / kg (maximum up to 4 mg).
Relief of already existing nausea and vomiting:
- Adults: intramuscularly or slowly intravenously - 4 mg;
- Children: slowly in / in - 0.1 mg / kg (maximum - up to 4 mg).
In case of exposure to ionizing radiation, the drug is taken orally, a single dose - 2 tablets of 4 mg (8 mg) 1 hour before or immediately after radiation.
For symptomatic therapy of alcoholic withdrawal syndrome, the solution is injected intravenously at a dose of 8 mg (2 ampoules of 2 ml or 1 ampoule of 4 ml are diluted in 400 ml of chlorine salt, hemodesis or 0.9% sodium chloride solution). If necessary, repeated administration of Latran is allowed.
No dosage changes are required in the elderly and patients with renal impairment.
In case of impaired liver function, the clearance of ondansetron is significantly reduced, and its half-life from plasma increases, therefore, a correction (decrease) in the daily dose to 8 mg is required.
The following infusion solutions can be used to dilute Latran solution:
- Ringer's solution;
- 5% dextrose solution;
- 0.3% potassium chloride solution and 0.9% sodium chloride solution;
- 0.9% sodium chloride solution;
- 0.3% potassium chloride solution and 5% dextrose solution.
Side effects
- Digestive system: dry mouth, hiccups, constipation, diarrhea, sometimes a transient asymptomatic increase in serum aminotransferase levels;
- Cardiovascular system: arrhythmias, chest pain (in some episodes with ST segment depression), lowering blood pressure, bradycardia;
- Nervous system: dizziness, headache, spontaneous movement disorders, convulsions;
- Allergic responses: angioneurotic edema, urticaria, laryngospasm, bronchospasm, anaphylaxis;
- Local reactions (parenteral administration): pain, redness and burning at the injection site;
- Other: a feeling of heat, flushing of the face, a temporary decrease in visual acuity, rarely - hypokalemia (unambiguous dependence on the drug intake has not been established).
In case of suspected overdose, symptomatic therapy is recommended.
There is no data on the specific antidote of ondansetron.
In case of an overdose with Latran tablets, it is not recommended to use Ipecacuana (emetic root), since the effectiveness of the emetic is unlikely during the period of inhibition of the vomiting reflex under the influence of ondansetron.
special instructions
Patients with a history of hypersensitivity reactions to other selective 5-HT3 receptor antagonists may develop similar responses to Latran.
In case of signs of intestinal obstruction after using the drug, regular monitoring of the patient is required, since ondansetron can cause constipation.
The infusion solution should be prepared immediately before use. The finished infusion solution can be stored at a temperature of 2 to 8 ° C for no more than a day before use.
During the infusion, it is not required to protect the solution from light, the ready-made injection solution remains stable for 24 hours under lamp illumination or natural light.
Drug interactions
Ondansetron is metabolized in the liver by the enzyme system (cytochrome P 450), therefore, care must be taken in the case of the combined use of Latran and the following drugs / substances:
- P 450 enzymatic inducers (CYP2D6 and CYP3A) - carbamazepine, rifampicin, carisoprodol, barbiturates, glutethimide, griseofulvin, papaverine, dinitrogen oxide, phenylbutazone, phenytoin (possibly other hydantoins), tolbutamide;
- Inhibitors of P 450 enzymes (CYP2D6 and CYP3A) - macrolide antibiotics, allopurinol, antidepressants (monoamine oxidase inhibitors), cimetidine, chloramphenicol, estrogen-containing oral contraceptives, disulfiram, diltiazem, valproicic acid sodium, lovidazolatol, ketoconazole, omeprazole, propranolol, quinine, quinidine, verapamil.
Analogs
Latran's analogs are: Vero-Ondansetron, Zofran, Domegan, Emetron, Osetron, Ondansetron, Ondansetron-Teva, Ondansetron-Ronts, Ondatron, Ondasol, Emeset.
Terms and conditions of storage
Store in a place protected from light, out of reach of children, at a temperature not exceeding 25 ° C.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Latran: prices in online pharmacies
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Drug name Price Pharmacy |
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Latran 2 mg / ml solution for intravenous and intramuscular administration 2 ml 5 pcs. RUB 138 Buy |
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Latran solution for intravenous and intramuscular injection. 0.2% 2ml 5 pcs. 157 r Buy |
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Latran 2 mg / ml solution for intravenous and intramuscular administration 4 ml 5 pcs. 217 r Buy |
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Latran solution for intravenous and intramuscular injection. 0.2% 4ml 5 pcs. 245 RUB Buy |
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Latran 4 mg film-coated tablets 10 pcs. 305 RUB Buy |
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Latran tablets p.p. 4mg 10 pcs. RUB 314 Buy |
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
