Yohimbine Hydrochloride

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Yohimbine hydrochloride: instructions for use and reviews

1. Release form and composition
2. Pharmacological properties
3. Indications for use
4. Contraindications
5. Method of application and dosage
6. Side effects
7. Overdose
8. Special instructions
9. Application during pregnancy and lactation
10. Use in childhood
11. In case of impaired renal function
12. For violations of liver function
13. Drug interactions
14. Analogs
15. Terms and conditions of storage
16. Terms of dispensing from pharmacies
17. Reviews
18. Price in pharmacies

Latin name: Yohimbin hydrochloride

ATX code: G04BE04

Active ingredient: Yohimbine (Yohimbine)

Producer: HEALTH PHARMACEUTICAL COMPANY (Ukraine)

Description and photo update: 2018-14-05

Prices in pharmacies: from 431 rubles.

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Yohimbine hydrochloride is a drug used to treat impotence.

Release form and composition

Dosage form - tablets: white or white with a yellowish tinge, with a bevel (in polymer containers or plastic cans of 50 pcs., In a cardboard box 1 container / can).

Composition of 1 tablet:

active substance: yohimbine hydrochloride - 5 mg;
auxiliary components: lactose monohydrate, potato starch, calcium stearate.

Pharmacological properties

Pharmacodynamics

Yohimbine is a selective blocker of α ₂ -adrenergic receptors. It increases the release of norepinephrine from nerve endings and the flow of sympathetic impulses from the central nervous system, thus exerting a sympathomimetic effect.

The drug increases motor activity, causes vasodilation of the genital, intestinal and renal arteries; stimulates sexual activity.

It has been experimentally established that yohimbine helps to normalize sexual function and the ability to coitus, weakened by stress; has a stimulating effect on the central nervous system; eliminates the inhibition of erection associated with the stimulation of α ₂ -adrenergic receptors.

Yohimbine hydrochloride is a low-toxic drug that does not affect the genetic apparatus of sperm cells.

Pharmacokinetics

Yohimbine 45-60 minutes after ingestion is completely absorbed in the digestive tract. The maximum concentration in the blood is reached approximately 45–75 minutes after oral administration. 82% of plasma yohimbine binds to protein.

The substance is evenly distributed in the tissues. It is metabolized both in the liver and outside it. Cumulation of the drug when taken orally in the recommended doses does not occur.

The half-life after a single dose ranges from 0.25 to 2.5 hours. After 24 hours, yohimbine is practically not detected in the urine. Excretion mainly occurs by the kidneys.

Indications for use

According to the instructions, Yohimbine hydrochloride is used as a potency-enhancing agent for the treatment of impotence in a functional and mental form.

Contraindications

Absolute:

severe hepatic / renal failure;
arterial hypo- or hypertension;
intolerance to galactose, glucose-galactose malabsorption or lactase deficiency (the drug contains lactose);
combination therapy with adrenergic agonists;
childhood;
individual intolerance to the components of the drug.

Relative (diseases / conditions in the presence of which caution is required):

heart disease (tachyarrhythmias, ischemic heart disease);
mental illness;
peptic ulcer of the stomach and duodenum;
glaucoma.

Instructions for the use of Yohimbine hydrochloride: method and dosage

The tablets are taken orally with a glass of water, preferably with meals. Do not chew the tablets.

Recommended regimen of the drug: 1-3 times a day, 1-2 tablets.

Maximum doses: single - 2 tablets; daily - 6 tablets.

It is advisable to carry out a treatment course lasting 3-4 weeks. If necessary, it is possible to repeat therapy.

Side effects

Possible side reactions: vomiting, migraine, dizziness, gastralgia, headache, anxiety, diarrhea, hand tremor, priapism, increased / decreased blood pressure, tachycardia, orthostatic hypotension.

Overdose

The main symptoms: general weakness, excessive sweating, dizziness, tremor, tachycardia, fear, arterial hypertension, generalized paresthesia, memory and coordination disorders, severe headache, a significant increase in the plasma level of norepinephrine in the blood, vomiting, nausea, lacrimation and salivation, mydriasis.

Therapy: as an antidote, it is possible to use clonidine (0.1–0.2 mg orally, then again with intervals of 1 hour, 0.1 mg each until the condition is completely normalized), which immediately eliminates the clinical manifestations of intoxication. A hypertensive crisis is stopped by a combination of a β-adrenergic receptor blocker and an α-adrenergic receptor blocker or a peripheral vasodilator. Benzodiazepines are used to treat hallucinations or feelings of fear. It is impossible to prescribe antipsychotics of the phenothiazine series.

special instructions

Influence on the ability to drive vehicles and complex mechanisms

It is recommended to refuse to drive vehicles during the period of therapy.

Application during pregnancy and lactation

Yohimbine hydrochloride is not intended for use in women.

Pediatric use

For pediatric patients, the drug is not prescribed.

With impaired renal function

Severe renal impairment is a contraindication to the use of yohimbine.

For violations of liver function

Severe hepatic impairment is a contraindication to the use of the drug.

Drug interactions

With the simultaneous use of certain drugs / substances, the following effects may develop:

clonidine: mutual neutralization of the action of drugs (the combination is not recommended);
clomipramine: increased plasma levels of yohimbine in the blood;
drugs with antihypertensive action: changes in their activity;
antidepressants: potentiation of their action;
alprozalam: an increase in the likelihood of adverse reactions, a decrease in its activity.

Analogs

The analogue of Yohimbine hydrochloride is Yohimbine "Der Spiegel".

Terms and conditions of storage

Store in a place protected from light and moisture at temperatures up to 25 ° C. Keep out of the reach of children.

The shelf life is 3 years.

Terms of dispensing from pharmacies

Dispensed by prescription.

Reviews about Yohimbine hydrochloride

According to reviews, Yohimbine hydrochloride is an affordable and effective drug. In some cases, side effects develop, usually in the form of tremors, increased blood pressure, and tachycardia.

Also, the drug is sometimes used for fat burning (a side effect of yohimbine) as a component of sports nutrition. However, doctors warn against taking Yohimbine hydrochloride for purposes other than those indicated in the indications for use.

Price for Yohimbine hydrochloride in pharmacies

The price of Yohimbine hydrochloride (50 tablets per pack) is approximately 230 rubles.