Ibuprofen-VERTEX
Latin name: Ibuprofen-VERTEX
ATX code: M02AA13
Active ingredient: ibuprofen (Ibuprofen)
Manufacturer: Vertex, JSC (Russia)
Description and photo update: 2020-17-07
Ibuprofen-VERTEX is a non-steroidal anti-inflammatory drug (NSAID) for external use.
Release form and composition
The drug is produced in the form of a gel for external use 5%: transparent, colorless or with a pale yellow tint, with a specific odor, the presence of air bubbles and opalescence is allowed (20, 30, 50 or 100 g in an aluminum tube, in a cardboard box 1 tube and instructions for use of Ibuprofen-VERTEX).
1 g of gel contains:
- active substance: ibuprofen - 50 mg;
- additional components: methyl parahydroxybenzoate (methylparaben), trolamine (triethanolamine), ethyl alcohol 95% (ethanol 95%), dimethyl sulfoxide, propylene glycol, lavender oil, carbomer, orange blossom oil (neroli oil), purified water.
Pharmacological properties
Pharmacodynamics
Ibuprofen belongs to the group of NSAIDs, derivatives of propionic acid. The active substance has analgesic and anti-inflammatory effects. As a result of indiscriminate suppression of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2), the drug inhibits the production of prostaglandins, which are mediators of inflammation, pain and hyperthermic reaction.
The product is easy to apply and is actively absorbed by the skin due to the rapid evaporation of the ethyl alcohol included in the composition; when treating the skin, it demonstrates an additional cooling effect.
Pharmacokinetics
After 24 hours after external use of the gel, ibuprofen is detected in the epidermis and dermis. In blood plasma, the maximum concentration of the active substance when applied topically is 5% of that when using oral forms of ibuprofen. Clinically significant systemic absorption of the drug practically does not occur.
The metabolic process of the drug takes place in the liver. Ibuprofen is excreted mostly by the kidneys (with no more than 1% - unchanged) and to a small extent - with bile.
Indications for use
Ibuprofen-VERTEX is recommended for use as an anti-inflammatory and analgesic agent in the following conditions:
- arthritis;
- backache;
- muscle pain;
- neuralgia;
- pain caused by ligament injuries and sprains;
- sports injuries.
Contraindications
Absolute:
- violations of the integrity of the skin at the site of application of the gel (including weeping dermatitis, infected wounds and abrasions, eczema);
- a history of indications of hypersensitivity reactions (rhinitis, bronchial asthma, urticaria, Quincke's edema) due to the use of other NSAIDs (including acetylsalicylic acid);
- III trimester of pregnancy;
- age up to 14 years;
- hypersensitivity to any component of Ibuprofen-VERTEX.
Relative (in the presence of the following conditions / diseases, you should consult your doctor before starting drug therapy):
- allergic diseases or bronchial asthma in the acute phase or in history (due to the increased risk of bronchospasm);
- colitis, enteritis;
- peptic ulcer, including history;
- hemorrhagic diathesis;
- renal and / or hepatic impairment;
- I – II trimesters of pregnancy;
- breastfeeding period.
Ibuprofen-VERTEX, instructions for use: method and dosage
Ibuprofen-VERTEX 5% gel is intended for external use only.
When using a tube of gel for the first time, open the cap and make sure that the protective foil on its neck is intact. To open the foil, press on it with the outside of the tube lid.
After squeezing a dose equivalent to 50–125 mg of ibuprofen, which roughly corresponds to a 4–10 cm strip of gel, gently rub the product into the skin of the problem area until completely absorbed. You can reuse the gel no earlier than 4 hours later. It is allowed to treat the skin over the painful area with the drug no more than 4 times within 24 hours, the maximum daily dose is 500 mg. After each procedure, you must wash your hands immediately.
If, within 14 days of using Ibuprofen-VERTEX, the symptoms of the disease persist or become more pronounced, you need to stop using it and consult a specialist.
Side effects
Adverse events that have been recorded with short-term treatment with ibuprofen in a daily dose not exceeding 500 mg:
- gastrointestinal tract (GIT): with an unknown frequency - dyspepsia, abdominal pain;
- immune system: with an unknown frequency - hypersensitivity reactions: reactions from the respiratory tract (shortness of breath, dyspnea, bronchospasm, bronchial asthma, including its exacerbation), skin reactions (urticaria, purpura, pruritus, angioedema, bullous and exfoliative dermatoses, incl. including erythema multiforme and toxic epidermal necrolysis), nonspecific allergic and anaphylactic reactions;
- kidneys and urinary tract: with unknown frequency - functional disorders of the kidneys.
With the treatment of chronic conditions and with a long course, there is a possibility of developing other adverse reactions.
Overdose
When treating with Ibuprofen-VERTEX gel, the risk of accidental overdose is minimal.
Overdose symptoms in children may occur after oral administration of a dose exceeding 400 mg / kg. The dose-dependent effect when using an excessive dose in adults is less pronounced. The half-life of ibuprofen in case of overdose can vary from 1.5 to 3 hours.
If Ibuprofen-VERTEX gel was inadvertently administered orally, the following symptoms may occur: lowering blood pressure, vomiting, headache. In this condition, gastric lavage is recommended (no later than 1 hour after ingestion), the use of activated carbon, forced diuresis, alkaline drinking, symptomatic treatment.
special instructions
It is not necessary to apply the gel under an occlusive (airtight) medical dressing.
It is required to beware of contact with Ibuprofen-VERTEX on inflamed / damaged areas of the skin, in the eyes and on other mucous membranes (including lips).
Avoid exposure to sunlight on the site of application of Ibuprofen-VERTEX.
Influence on the ability to drive vehicles and complex mechanisms
The drug does not affect the ability to drive vehicles and control other moving complex mechanisms.
Application during pregnancy and lactation
In the III trimester of pregnancy, Ibuprofen-VERTEX is contraindicated, in the I – II trimesters it can be used only on the recommendation of the attending physician.
According to the available data, small amounts of ibuprofen can be excreted in breast milk without any adverse effects on the health of the infant. As a result of this, as a rule, with a short use of the product, there is no need to refuse breastfeeding.
If long-term drug therapy is required during lactation, the issue of stopping breastfeeding for the period of treatment should be resolved.
Pediatric use
Ibuprofen-VERTEX is not used in patients under 14 years of age.
With impaired renal function
In case of concomitant disorders of the kidney function, treatment with the drug should be carried out with extreme caution.
For violations of liver function
In case of concomitant violations of the liver, use Ibuprofen-VERTEX with extreme caution.
Drug interactions
There is no description of the interaction of ibuprofen in the form of a gel for external use with other medicinal substances / preparations.
- antihypertensive drugs, thrombolytic drugs, other NSAIDs, anticoagulants, acetylsalicylic acid: these drugs must be used with caution in combination with the drug;
- other NSAIDs: there is a risk of systemic action of ibuprofen even with external use, theoretically, when combined with other NSAIDs, an aggravation of the severity of adverse reactions may occur.
Analogs
Ibuprofen-VERTEX analogs are Ibuprofen, Dolgit, Deep Relief, Nurofen Express, etc.
Terms and conditions of storage
Store out of the reach of children at a temperature not exceeding 25 ° C.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Ibuprofen-VERTEX
Reviews about Ibuprofen-VERTEX, found on specialized sites, are mostly positive. Patients note that the drug relieves moderate pain in arthritis, neuralgia, sports injuries, ligament injuries and sprains well. The gel also effectively and quickly relieves back pain of various origins, pain in joints and muscles, does not leave greasy marks on clothes, and has a low cost.
The disadvantages of Ibuprofen-VERTEX include the presence of a large list of contraindications, a short therapeutic effect and side effects, especially from the gastrointestinal tract. In rare cases, indicate a complete lack of improvement after using the gel.
The price of Ibuprofen-VERTEX in pharmacies
The price of Ibuprofen-VERTEX 5% in the form of a gel for external use can be 80–90 rubles. for a tube of 50 g.
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
