Zedex - Instructions For The Use Of Syrup, Price, Reviews, Analogues

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Zedex

Zedex: instructions for use and reviews

1. 1. Release form and composition
2. 2. Pharmacological properties
3. 3. Indications for use
4. 4. Contraindications
5. 5. Method of application and dosage
6. 6. Side effects
7. 7. Overdose
8. 8. Special instructions
9. 9. Application during pregnancy and lactation
10. 10. Use in childhood
11. 11. In case of impaired renal function
12. 12. For violations of liver function
13. 13. Drug interactions
14. 14. Analogs
15. 15. Terms and conditions of storage
16. 16. Terms of dispensing from pharmacies
17. 17. Reviews
18. 18. Price in pharmacies

Latin name: Zedex

ATX code: R05FB01

Active ingredient: Bromhexin (Bromhexine), Dextromethorphan (Dextromethorphan)

Manufacturer: WOCKHARDT Ltd. (India)

Description and photo updated: 2018-26-07

Zedex is a combined drug with antitussive and expectorant effects.

Release form and composition

Dosage form of release - syrup: transparent, thick, orange, has the smell of menthol (in polyethylene bottles of 100 ml, in a cardboard box 1 bottle complete with a plastic cup of 10 ml).

Active substances in 1 ml of syrup:

• dextromethorphan hydrobromide - 1 mg;
• bromhexine hydrochloride - 0.8 mg;
• ammonium chloride - 10 mg.

Auxiliary components: propylene glycol - 36.33 mg; sodium saccharinate - 3 mg; levomenthol - 0.5 mg; vanillin - 0.1 mg; sucrose - 600 mg; benzoic acid - 0.7 mg; dextrose - 350 mg; sodium benzoate - 0.35 mg; fruit flavor - 0.0012 ml; sunset yellow dye - 0.067 mg; purified water - up to 1 ml.

Pharmacological properties

Zedex is a combined drug, the action of which is due to its constituent components:

• dextromethorphan: has an antitussive and sedative effect, increases the threshold of sensitivity of the cough center of the medulla oblongata (it does not lead to depression of the respiratory center), does not have an analgesic effect, does not cause an addictive effect;
• bromhexine: has a secretolytic (mucolytic), expectorant and slight antitussive effect; mucolytic effect is provided due to depolymerization and liquefaction of mucopolysaccharide and mucoprotein fibers;
• ammonium chloride: has an expectorant effect.

Indications for use

Zedex is prescribed to relieve the symptoms of flu, colds, acute respiratory viral infections that occur with coughing.

Contraindications

Absolute:

• exacerbation of peptic ulcer;
• combined use with other drugs containing the substances included in Zedex;
• age up to 6 years;
• pregnancy and the period of breastfeeding;
• individual intolerance to the components of the drug.

Relative (diseases / conditions in the presence of which caution is required):

• renal / hepatic impairment;
• bronchial asthma.

Instructions for the use of Zedex: method and dosage

The syrup is taken orally.

Recommended application scheme:

• adults and children from 12 years old: 2-3 times a day, 2 teaspoons;
• children 6-12 years old: 3-4 times a day, 1 / 2-1 teaspoon.

Side effects

Possible side reactions: exacerbation of peptic ulcer disease, dyspeptic symptoms, allergic reactions (in the form of skin rash, rhinitis, etc.), increased serum transaminase levels, sleep disturbance, drowsiness, increased excitability (especially in children).

Overdose

The main symptoms: nausea, vomiting and other disorders of the digestive system, agitation of the central nervous system.

Therapy: taking activated charcoal, gastric lavage, symptomatic treatment.

Overdoses that are life-threatening are unknown.

special instructions

You should refrain from drinking alcohol during treatment.

Influence on the ability to drive vehicles and complex mechanisms

When driving a vehicle, patients are advised to be careful during therapy.

Application during pregnancy and lactation

The drug is contraindicated for use during pregnancy and lactation.

Pediatric use

The drug is not prescribed for children under 6 years of age. In older children, therapy can only be carried out according to strict indications.

With impaired renal function

In renal failure, Zedex should be administered with caution.

For violations of liver function

In liver failure, Zedex should be administered with caution.

Drug interactions

The simultaneous use of other drugs used to treat bronchopulmonary diseases is possible.

Simultaneously with drugs with antitussive action (including those containing codeine) Zedex is not prescribed.

The alcohol that is part of the syrup can change the effect of drugs used simultaneously.

Bromhexine, which is part of Zedex, promotes better penetration of antibiotics (amoxicillin, cephalexin, erythromycin, ampicillin, oxytetracycline) into the lung tissue, however, its combined use with salicylates, oxyphenbutazone and phenylbutazone can lead to severe irritation of the gastric mucosa.

Possible interactions with dextromethorphan:

• monoamine oxidase inhibitors: effects on the central nervous system and severe respiratory depression (the combination is contraindicated);
• amiodarone: inhibition of dextromethorphan metabolism in the liver and an increase in its toxicity (the combination is contraindicated);
• antidepressants of the group of serotonin reuptake inhibitors, including paroxetine, fluoxetine: development of interaction (the combination is contraindicated);
• opioids: potentiation of their analgesic effect.

Analogs

There is no information about Zedex analogues.

Terms and conditions of storage

Store in a place protected from moisture at temperatures up to 30 ° C in tightly closed bottles. Keep out of the reach of children.

The shelf life is 3 years.

Terms of dispensing from pharmacies

Available without a prescription.

Reviews about Zedex

Reviews about Zedex are not presented, since the drug is not available in pharmacies.

Price for Zedex in pharmacies

The price of Zedex is unknown due to its absence in the pharmacy chain.

Group analogues are available:

• Stopussin (drops for oral administration): 10 ml - about 140 rubles; 50 ml - 330 rubles;
• Stopussin (tablets): 20 pcs. - about 240 rubles;
• Codelac Broncho (tablets): 10 pcs. - about 135 rubles; 20 pcs. - 190 rubles.

Maria Kulkes Medical journalist About the author

Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!