Driptan
Driptan: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Use in the elderly
- 14. Drug interactions
- 15. Analogs
- 16. Terms and conditions of storage
- 17. Terms of dispensing from pharmacies
- 18. Reviews
- 19. Price in pharmacies
Latin name: Driptane
ATX code: G04BD04
Active ingredient: oxybutynin (oxybutynin)
Manufacturer: Laboratories Fournier S. A. (Laboratoires Fournier, SA) (France), Recipharm Fontaine (France)
Description and photo update: 2019-20-08
Prices in pharmacies: from 678 rubles.
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Driptan is a drug that has a direct spasmolytic, m-anticholinergic and myotropic effect; relaxes the detrusor and reduces the frequency of its contractions, increases the capacity of the bladder and restrains the urge to urinate.
Release form and composition
Driptan is available in the form of tablets: round, biconvex, white, with a line on one side (30 pcs. In blisters, 1 or 2 blisters in a cardboard box).
Active ingredient: oxybutynin hydrochloride, 1 tablet - 5 mg.
Additional components: microcrystalline cellulose, calcium stearate and lactose.
Pharmacological properties
Pharmacodynamics
The active ingredient of Driptan is oxybutynin, a substance that has an antispasmodic effect on detrusor smooth muscle fibers, as well as an anticholinergic effect (due to the ability to block the effect of acetylcholine on m-cholinergic receptors of smooth muscles). These properties of the drug help to relax the detrusor of the bladder.
In case of instability of the bladder function, Driptan increases its volume and reduces the frequency of spontaneous detrusor contractions.
Pharmacokinetics
After entering the gastrointestinal tract, oxybutynin is rapidly and completely absorbed. The peak plasma concentration is reached in less than 1 hour, after which it decreases in two phases with a half-life of 2-3 hours. The maximum effect is observed after 3-4 hours, the residual effect can be observed for 10 or more hours.
Equilibrium concentration is achieved after 8 days of regular intake of Driptan.
The pharmacokinetic parameters of oxybutynin in the elderly do not differ from those in adult patients. In older people who are active, the drug probably does not accumulate. In weakened elderly patients, the indicators of the maximum concentration of the drug in the blood and the area under the concentration-time curve significantly increase.
The drug undergoes intensive metabolism in the liver, mainly with the participation of enzymes of the cytochrome P450 system, in particular CYP3A4, an isoenzyme found mainly in the intestinal walls and in the liver. Oxybutynin metabolites also have m-anticholinergic activity. The drug is excreted through the kidneys.
In animal studies, it was found that only 0.3-0.4% of unchanged oxybutynin is detected in the urine of rats 24 hours after its application, 1% in the urine of dogs after 48 hours. Thus, in rats and dogs, the drug is almost completely metabolized.
Indications for use
According to the instructions, Driptan is used to treat urinary incontinence associated with the instability of the bladder function due to the following disorders:
- Neurogenic disorders (detrusor hyperreflex), for example, due to widespread sclerosis or spina bifida (spina bifida);
- Idiopathic disorders of detrusor function.
Also, Driptan tablets are used to treat nocturnal enuresis in children over 5 years old.
Contraindications
Absolute:
- Intestinal atony;
- Obstruction of the gastrointestinal tract;
- Ulcerative colitis;
- Dilation of the colon;
- Obstructive uropathy;
- Myasthenia gravis;
- Closed-angle glaucoma;
- Bleeding;
- Children under 5 years old;
- Lactation;
- Hypersensitivity to drug components.
Relative:
- Impaired liver and kidney function;
- Arterial hypertension;
- Arrhythmias;
- Heart failure;
- Cardiac ischemia;
- Benign prostatic hyperplasia;
- Hernia of the esophageal opening of the diaphragm;
- Pregnancy.
Instructions for the use of Driptan: method and dosage
Driptan tablets should be taken orally.
Adult patients are prescribed 1 tablet 2-3 times a day.
Elderly people and children - 1 tablet 2 times a day.
Side effects
- Digestive system: dry mouth, diarrhea and / or constipation, nausea, abdominal discomfort;
- Central nervous system: general weakness, insomnia or drowsiness, headache, vertigo;
- Organ of vision: increased intraocular pressure, visual impairment (accommodation paralysis, mydriasis);
- Others: decreased sweating, urinary retention, allergic reactions, arrhythmias, impotence.
Overdose
Signs of an overdose increase gradually: starting with an increase in side effects from the central nervous system (from emotional excitement and anxiety to psychotic behavior), the development of circulatory disorders (hot flushes, circulatory failure, a drop in blood pressure, etc.) to paralysis, respiratory failure, coma.
After taking a dose that is significantly higher than the recommended one, you should immediately flush the stomach. Treatment of fever is symptomatic. Significant agitation or irritability is eliminated by intravenous administration of diazepam at a dose of 10 mg. With the development of a life-threatening anticholinergic syndrome, neostigmine / physostigmine may be prescribed (in the doses indicated in the instructions). If tachycardia develops, propranolol is administered intravenously. With paralysis of the respiratory muscles, artificial ventilation of the lungs is required, with urinary retention - the installation of a catheter.
special instructions
Elderly patients should be careful when using anticholinergic drugs, as there is a risk of cognitive impairment. After the appointment of Driptan, cardiac arrhythmias, the development of tachycardia, increased symptoms of hyperthyroidism, arterial hypertension, chronic heart failure, coronary artery disease, and prostatic hyperplasia are possible.
There are known cases of the development of anticholinergic effects from the nervous system against the background of the use of Driptan (for example, drowsiness, confusion, hallucinations, agitation). In this regard, in the first few months of treatment, as well as when the dose is increased, it is recommended to monitor the patient's condition. With the development of adverse reactions from the nervous system, consideration should be given to reducing the dose of the drug or completely canceling it.
Driptan can lead to the development of angle-closure glaucoma. If you experience pain in your eyes or a sudden decrease in visual acuity, you should immediately consult a doctor.
In in vitro and animal studies, oxybutynin has been shown to increase the synthesis of porphyrinogens, so Driptan should be used with caution in patients with porphyria.
With prolonged use of the drug, there is a risk of caries development due to a decrease or suppression of saliva production, therefore, patients receiving Driptan for a long time are recommended to be observed by a dentist.
Influence on the ability to drive vehicles and complex mechanisms
Driptan can cause drowsiness and reduce visual acuity. In these cases, for the duration of treatment, it is worth refraining from driving a car and performing activities with potentially dangerous consequences.
Application during pregnancy and lactation
In animal studies, it was found that the use of oxybutynin in doses that have a toxic effect on the maternal body causes reproductive toxicity, but these data are insufficient to assess the effect of the drug on the course of pregnancy, fetal development, childbirth, and postnatal development. The safety of using the drug in pregnant women has not been studied. In this regard, for pregnant women, the appointment of Driptan is allowed only if the expected benefit from therapy for women is definitely higher than the possible risks to the fetus.
According to animal studies, oxybutynin passes into breast milk, so Driptan is contraindicated during lactation.
Pediatric use
Due to insufficient data on safety and efficacy, Driptan is not allowed to be used to treat children under 5 years of age.
Therapy for children from 5 years of age should be carried out with extreme caution, since the child's body may be more sensitive to the action of oxybutynin, which increases the risk of developing mental and nervous system disorders.
With impaired renal function
Driptan in renal failure should be used with extreme caution.
For violations of liver function
Driptan for liver failure should be used with extreme caution.
Use in the elderly
Elderly patients during the period of therapy should be under special medical supervision, since in old age, against the background of anticholinergics, the risk of side effects increases.
Drug interactions
Particular care is required if the simultaneous use of other anticholinergics is necessary, since the effect may be enhanced.
There are isolated reports of cases of interactions of anticholinergic drugs with the following drugs: dipyridamole, amantadine, quinidine, atropine, phenothiazines, atropine-like antispasmodics, tricyclic antidepressants, digitalis drugs, antihistamines, antipsychotics (eg, clozapine, phenothiazines), levodopa, biperidine). If necessary, their combined use with Driptan should be used with caution.
Oxybutynin may decrease the effectiveness of cholinesterase inhibitors and prokinetic therapy.
With the simultaneous use of CYP3A4 inhibitors, it is possible to suppress the metabolism of oxybutynin and enhance its action.
Ethanol may increase sleepiness caused by oxybutynin.
Driptan, due to a decrease in gastrointestinal motility, can affect the absorption of other drugs taken simultaneously.
Analogs
Driptan's analogs are: Oxybutynin, Sibutin, Vesikar, Dream-Apo, Detruzitol, Novitropan, Spazmex, Uroholum, Zevesin, Urotol.
Terms and conditions of storage
Keep out of the reach of children, at a temperature not exceeding 30 ° C.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Driptan
According to most reviews, Driptan is an effective, fast-acting drug that helps with neurogenic urinary disorders and overactive bladder.
There are some statements about the lack of effect of therapy or about the development of side effects.
Driptan price in pharmacies
The approximate price of Driptan is 605-680 rubles. per pack containing 30 tablets.
Driptan: prices in online pharmacies
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Drug name Price Pharmacy |
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Driptan 5 mg tablets 30 pcs. RUB 678 Buy |
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Driptan tablets 5mg 30 pcs. 752 RUB Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
