Dorithricin
Dorithricin: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Dorithricin
ATX code: R02AA20
Active ingredient: Tyrotrocin (Tyrothricin), benzalkonium chloride (Benzalkonium chloride) and benzocaine (Benzocaine)
Producer: Riemser Specialty Production GmbH (Germany)
Description and photo update: 18.10.2018
Prices in pharmacies: from 311 rubles.
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Dorithricin is a complex preparation for topical use in otorhinolaryngology and dentistry with antimicrobial and local anesthetic action.
Release form and composition
Dosage form - lozenge tablets: white, round, beveled, flat-cylindrical, with the DORITHRICIN marking on one side; with a characteristic mint smell (10 pcs. in a blister, in a cardboard box 1 blister).
1 tablet contains:
- active ingredients: benzocaine - 1.5 mg, benzalkonium chloride - 1 mg, tyrothricin - 0.5 mg;
- auxiliary components: sorbitol, povidone (polyvidone K25), sucrose stearate, sodium carmellose, sodium saccharinate, peppermint leaf oil, talc.
Pharmacological properties
Pharmacodynamics
Benzocaine is a local anesthetic that reduces pain when swallowing, which accompanies infectious and inflammatory pathologies of the mouth and throat.
Benzalkonium chloride is a quaternary ammonium compound, a cationic surfactant that disrupts the permeability of cell membranes, interacts with lipoproteins. It has an antiseptic effect, is effective against gram-positive bacteria, fungus of the genus Candida albicans, some lipophilic viruses.
Tyrothricin is an antibiotic consisting mainly of tyrocidin and gramicidin. It has a bactericidal local effect, which causes rupture of phosphorylation processes in the chain of cellular respiration and destruction of bacterial cell membranes. Unlike systemic antibiotics, tyrothricin has a specific mechanism of action that does not cause cross-resistance to the drug.
Pharmacokinetics
Benzocaine is slowly absorbed due to its low water solubility. Being an ester derivative of para-aminobenzoic acid, it is cleaved by esterase in the liver and blood plasma to form para-aminobenzoic acid and ethyl alcohol. Ethyl alcohol metabolism ends with the formation of acetyl coenzyme A.
Para-aminobenzoic acid is excreted by the kidneys unchanged or is conjugated with glycine.
Benzalkonium chloride is almost not absorbed, therefore it does not have a resorptive effect and is excreted by the kidneys. Its accumulation was not found in body tissues.
Tyrothricin - systemic absorption is very low, does not affect the intestinal microflora.
Indications for use
The use of Doritricin is indicated for the treatment of infectious and inflammatory diseases of the oral cavity and pharynx, occurring with pain:
- pharyngitis, the initial stage of angina, laryngitis;
- gingivitis, stomatitis (inflammation of the mucous membrane of the mouth and gums).
Contraindications
- syndrome of glucose-galactose malabsorption, hereditary fructose intolerance, isomaltase or sucrase deficiency;
- age up to 6 years;
- individual hypersensitivity to the components of the drug.
Instructions for the use of Doritricin: method and dosage
The tablets are taken orally, held in the mouth for slow dissolution.
Recommended dosage for patients over 6 years old: 1 pc. every 3 hours, but no more than 6 pcs. in a day.
Duration of treatment is 7 days. The extension of the course of therapy must be agreed with the doctor.
Side effects
- possible: development of allergic reactions;
- rarely: nausea, diarrhea.
Overdose
Overdose can occur if you accidentally take large doses of the drug. Symptoms: nausea, vomiting, diarrhea.
The patient needs to wash the stomach and take activated charcoal. In the absence of improvement, seek medical attention.
special instructions
Patients with diabetes should take into account that the carbohydrate content in 1 tablet is about 0.07 XE (bread units).
If pronounced undesirable effects appear, you should consult a doctor.
Influence on the ability to drive vehicles and complex mechanisms
According to the instructions, Dorithricin does not affect the speed of psychomotor reactions and concentration of the patient's attention.
Application during pregnancy and lactation
During pregnancy and breastfeeding, the use of the drug is possible if, in the opinion of the doctor, the potential threat to the fetus and child is lower than the expected effect of therapy for the mother.
Pediatric use
Contraindicated for children under 6 years of age.
Drug interactions
A clinically significant interaction of Dorithricin in combination with other drugs has not been established.
Analogs
Doritricin analogues are: Aqua Maris, Ajisept, Anginal, Efizol, Hepilor, Anzibel, Furassol.
Terms and conditions of storage
Keep out of the reach of children.
Store at temperatures up to 25 ° C, protected from moisture and light.
The shelf life is 5 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews of Dorithricin
Reviews of Dorithricin indicate the high effectiveness of the drug. The analgesic effect occurs immediately after taking the pill. There is no need for additional intake of funds to prevent the state of the intestinal microflora, since the tablets dissolve in the mouth.
Price for Dorithricin in pharmacies
The price of Doritricin per pack is about 180 rubles.
Doritricin: prices in online pharmacies
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Drug name Price Pharmacy |
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Doritricin lozenges 10 pcs. RUB 311 Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
