Derinat
Derinat: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Derinat
ATX code: L03A
Active ingredient: sodium desoxyribonucleate
Manufacturer: JSC "FP" Technomedservice "(Russia)
Description and photo update: 2019-16-08
Prices in pharmacies: from 208 rubles.
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Derinat is an immunomodulatory drug.
Release form and composition
Derinat is available in the following dosage forms:
- Solution for intramuscular injection: colorless, transparent, without foreign inclusions (2 or 5 ml in glass vials, 5 (5 ml) or 10 (2 ml) vials in a pallet, 1 pallet in a cardboard box);
- Solution for local and external use 0.25%: colorless, transparent, without foreign inclusions (10 or 20 ml in glass bottles or 10 ml in dropper bottles or bottles with a spray nozzle, 1 bottle in a cardboard box).
The composition of 1 ml of solution for intramuscular administration includes:
- Active ingredient: sodium deoxyribonucleate - 15 mg;
- Auxiliary components: sodium chloride, water for injection.
The composition of 1 ml of solution for local and external use includes:
- Active ingredient: sodium deoxyribonucleate - 2.5 mg;
- Auxiliary components: sodium chloride, water for injection.
Pharmacological properties
Pharmacodynamics
Derinat activates the processes of humoral and cellular immunity. Immunomodulatory action is provided by stimulation of B-lymphocytes and activation of T-helpers. The drug activates nonspecific resistance of the body, optimizes inflammatory reactions, as well as the immune response to viral, fungal and bacterial antigens. Promotes stimulation of regenerative and reparative processes. Increases the body's resistance to infections, regulates hematopoiesis (ensures the normalization of the number of lymphocytes, leukocytes, granulocytes, platelets, phagocytes).
Due to the pronounced lymphotropicity, taking Derinat stimulates the drainage and detoxification functions of the lymphatic system. The drug significantly reduces the sensitivity of cells to the effects of radiation therapy and chemotherapy drugs. It has no embryotoxic, teratogenic and carcinogenic effects.
Pharmacokinetics
It is rapidly absorbed, distributed in tissues and organs through the endolymphatic transport path. It has a high tropism for the organs of the hematopoietic system, is embedded in cellular structures, due to which it actively participates in cellular metabolism. In the phase of intensive entry into the blood, in parallel with the processes of metabolism and excretion, the drug is redistributed between the blood plasma and its formed elements. After a single injection, all pharmacokinetic curves of changes in the concentration of sodium deoxyribonucleate in the studied tissues and organs show rapid phases of increase and decrease in concentration in the time interval from 5 to 24 hours. When administered intramuscularly, the half-life is 72.3 hours.
It is quickly distributed in the body, during the daily course of treatment it accumulates in tissues and organs (mainly in the lymph nodes, bone marrow, thymus, spleen). To a lesser extent, the drug is accumulated in the brain, liver, stomach, large and small intestines. The time to reach the maximum concentration in the bone marrow is 5 hours, and in the brain - 30 minutes. Penetrates the blood-brain barrier.
It is metabolized in the body. It is excreted by biexponential dependence in the form of metabolites in the urine, to a lesser extent in the feces.
Indications for use
According to the instructions, Derinat in the form of a solution for intramuscular administration is used in the treatment of diseases / conditions such as:
- Violation of hematopoiesis;
- Radiation damage;
- Resistance and myelodepression to cytostatics in cancer patients associated with radiation and / or cytostatic therapy (stabilization of hematopoiesis, lowering of myelo- and cardiotoxicity of chemotherapy drugs);
- Stomatitis induced by cytostatic drugs;
- Erosive gastroduodenitis, gastric ulcer and duodenal ulcer;
- Obliterating vascular diseases of the lower extremities (stage II-III);
- Ischemic heart disease (CHD);
- Purulent septic complications, odontogenic sepsis;
- Long-term non-healing wounds, trophic ulcers;
- Pulmonary tuberculosis, inflammatory diseases of the respiratory tract;
- Burn disease;
- Rheumatoid arthritis;
- Endometritis, endometriosis, salpingo-oophoritis, fibroids;
- Ureaplasmosis, chlamydia, mycoplasmosis;
- Chronic obstructive pulmonary disease;
- Benign prostatic hyperplasia, prostatitis;
- Pre- and postoperative periods (in surgical practice).
As monotherapy Derinat in the form of a solution for local and external use is used for the following diseases:
- Dystrophic and inflammatory eye diseases;
- Inflammatory diseases of the oral mucosa;
- Acute respiratory viral infection (treatment and prevention);
- Acute respiratory diseases (ARI).
As part of a complex treatment, a solution for local and external use Derinat is prescribed for the treatment of diseases such as:
- Chronic and acute diseases of the upper respiratory tract (rhinitis, sinusitis, including sinusitis, frontal sinusitis);
- Fungal, chronic inflammatory diseases, bacterial and other infections of the mucous membranes in gynecological practice;
- Infected and non-healing wounds (including diabetes mellitus);
- Obliterating diseases of the lower extremities;
- Gangrene;
- Trophic ulcers;
- Post-radiation necrosis of the skin and mucous membranes;
- Frostbite;
- Burns;
- Hemorrhoids.
Contraindications
Derinat is contraindicated in the presence of hypersensitivity to the drug components.
Instructions for the use of Derinat: method and dosage
For adults, Derinat is administered in the form of a solution for intramuscular administration for 1-2 minutes at an average single dose of 75 mg (5 ml of a solution for intramuscular administration of 15 mg / ml). The interval of administration is 24-72 hours.
Depending on the indications, the following treatment regimens are used:
- Ischemic heart disease - 5 ml of a 15 mg / ml solution, the interval between injections is 48-72 hours. Treatment course - 10 injections;
- Oncological diseases - 5 ml (75 mg per day), the interval between injections is 48-72 hours. Treatment course - 10 injections;
- Peptic ulcer and duodenal ulcer - 5 ml of a solution of 15 mg / ml, the interval between injections is 48 hours. Treatment course - 5 injections;
- Tuberculosis - 5 ml of a solution of 15 mg / ml, the interval between injections is 24-48 hours. Treatment course - 10-15 injections;
- Benign prostatic hyperplasia, prostatitis - 5 ml of a 15 mg / ml solution, the interval between injections is 24-48 hours. Treatment course - 10 injections;
- Chlamydia, endometriosis, endometritis, mycoplasmosis, ureaplasmosis, fibroids, salpingo-oophoritis - 5 ml of a solution of 15 mg / ml, the interval between injections is 24-48 hours. Treatment course - 10 injections;
- Chronic inflammatory diseases - 5 ml of a 15 mg / ml solution: the first 5 injections with a break of 24 hours each, the next - with an interval of 72 hours. Treatment course - 10 injections;
- Acute inflammatory diseases - 5 ml of a 15 mg / ml solution, the interval between injections is 24-72 hours. The treatment course is 3-5 injections.
When using a solution of 15 mg / ml, 2 ml injections should be carried out every day, recalculating, until a dose of 375-750 mg per course is reached.
The frequency of intramuscular administration of the drug in children is the same as in adults. The drug is used in the following doses:
- Up to 2 years: the average single dose is 7.5 mg (0.5 ml of a solution for intramuscular administration of 15 mg / ml);
- 2-10 years: a single dose is determined at the rate of 0.5 ml of the drug per year of life;
- Over 10 years: average single dose - 75 mg (5 ml of solution for intramuscular injection of 15 mg / ml), course dose - up to 5 injections of the drug.
Derinat in the form of a solution for external and local use is used depending on the localization of the ongoing process.
The drug can be used by adults and children from the first day of life.
For the prevention of ARVI, Derinat is dripped into the nose: in each nasal passage, 2 drops of the solution 2-4 times a day. The duration of therapy is 7-14 days. With the development of symptoms of a respiratory disease during the first day, Derinat is instilled into the nose with 2-3 drops in each nasal passage every 1-1.5 hours, then - 3-4 times a day, 2-3 drops. The duration of the treatment course can vary from 5 to 30 days.
Depending on the disease, Derinat is used according to the following schemes:
- Inflammatory diseases of the paranasal sinuses and nasal cavity - 4-6 times a day, 3-5 drops are instilled into each nasal passage. The duration of the treatment course is 7-15 days;
- Inflammatory diseases of the oral cavity - 4-6 times a day, you should rinse the mouth (1 bottle for 2-3 rinses). The duration of the treatment course is 5-10 days;
- Chronic inflammatory diseases, fungal, bacterial and other infections in gynecological practice - irrigation of the vagina and cervix or intravaginal administration of tampons with a solution is shown. For the procedure - 5 ml, frequency of application - 1-2 times a day. The duration of the treatment course is 10-14 days;
- Severe inflammatory and dystrophic processes in ophthalmic practice - Derinat 2-3 times a day should be instilled into the eyes, 1-2 drops. The duration of the treatment course is 14-45 days;
- Hemorrhoids - rectal administration of the drug is shown using microclysters of 15-40 ml. The duration of the treatment course is 4-10 days;
- Post-radiation necrosis of mucous membranes and skin, long-term non-healing wounds, burns, frostbite, gangrene, trophic ulcers of various etiology - 3-4 times a day, application dressings (gauze in 2 layers) with the applied solution should be applied to the affected areas. Also, the affected surface can be treated 4-5 times a day with a drug from a nebulizer, 10-40 ml. The duration of the treatment course is 1-3 months;
- Obliterating diseases of the lower extremities - to achieve a systemic effect, Derinat is instilled 6 times a day into each nasal passage, 1-2 drops. The duration of the treatment course is up to 6 months.
Side effects
With intravenous administration of Derinat in patients with diabetes mellitus, a hypoglycemic effect may be noted, which must be taken into account when controlling the level of glucose in the blood.
With local and external use of the drug, side effects have not been identified.
Overdose
No negative effects from overdose have been identified.
special instructions
Derinat has no embryotoxic, carcinogenic and teratogenic effects.
Subcutaneous administration of the drug is possible.
In surgical sepsis, the use of Derinat as part of complex therapy causes the activation of immunity, a decrease in the level of intoxication, and the normalization of hematopoiesis. There is also an improvement in the functioning of the organs responsible for the detoxification of the internal environment of the body (including the spleen and lymph nodes).
The drug reduces the iatrogenicity of basic drugs in the treatment of rheumatoid arthritis with 50% and 70% improvement in a number of complex indicators of disease activity.
Derinat potentiates the therapeutic effect of basic therapy for gastric ulcer and duodenal ulcer.
According to clinical studies, Derinat's efficacy has been proved against the background of standard therapy in patients with exacerbation of chronic obstructive pulmonary disease of varying severity. In this case, 5 ml of a solution of 15 mg / ml is used intramuscularly, the interval between injections is 24-48 hours. The treatment course is 5-10 injections.
With external and local application in the treatment of gangrenous processes under the influence of Derinat, spontaneous rejection of necrotic masses with restoration of the skin was noted in the foci of rejection. With burns and open wounds, an analgesic effect is noted.
Application during pregnancy and lactation
Derinat in the form of a solution for external and local use during pregnancy and lactation is used without restrictions.
Derinat in the form of a solution for intramuscular administration is used only after consulting a doctor. The decision to prescribe the drug to pregnant women should be made based on an assessment of the ratio of the expected benefits to the mother and the potential risk to the fetus.
Derinat in the form of a solution for intramuscular administration during lactation should be used exclusively as directed by a doctor.
Pediatric use
It is allowed to use Derinat to treat children from the first day of life.
Drug interactions
Derinat increases the effectiveness of cytostatics, antitumor antibiotics of the anthracycline series.
The use of Derinat as part of complex therapy allows to increase the effectiveness and shorten the duration of treatment with a significant reduction in doses of antibiotic drugs and antiviral agents with an increase in the periods of remission.
When applied topically, Derinat is incompatible with hydrogen peroxide and fat-based ointments.
Analogs
Derinat's analogs are: Deoxinate, Sodium deoxyribonucleate, Panagen.
Terms and conditions of storage
Store in a dark, dry place out of reach of children at a temperature of 4-20 ° C.
The shelf life is 5 years.
The contents of an opened bottle with a solution for local and external use must be used within 14 days.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Derinat
Reviews about Derinat are ambiguous: some users note its effectiveness, others report no changes in the course of the disease. The list of the main advantages of the drug includes ease of use, natural composition and safety. At the same time, some doctors note that Derinat's safety has not yet been fully studied.
Patients who were prescribed the drug in drops and in the form of injections report that such treatment allowed them to quickly get rid of the symptoms of the disease and reduce the likelihood of relapse.
In gynecology, Derinat injections are successfully used in the treatment of inflammatory processes (including in the cervix), fibroids, fibroids of the mammary glands, chlamydia, endometriosis, as well as in the treatment of tumors and as a universal immunocorrector for hormone-dependent endometrial hyperplasia.
Many parents also speak positively of Derinat as a remedy for combating "kindergarten infections": according to them, the drug activates the body's defenses and promotes a more rapid maturation of the immune system. Also, the drug has proven itself well in the treatment of children with adenoids, rhinitis, sinusitis, tonsillitis, bronchial asthma. According to parental reviews, the use of the drug in the treatment of viral infections greatly reduces the severity of the symptoms of the disease and the likelihood of complications. To get the maximum effect from the drug, some users advise using it for the prevention of acute respiratory viral infections and influenza, or in the early stages of the disease.
The negative reviews about Derinat mainly contain information about the painfulness of injections and the short-term effect of treatment.
Derinat price in pharmacies
The approximate price for Derinat is: spray 0.25% 10 ml - 405 rubles, a dropper bottle of 0.25% 10 ml - 340 rubles, 5 bottles with a solution for intramuscular injection of 15 mg / 5 ml - 2225 rubles.
Derinat: prices in online pharmacies
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Drug name Price Pharmacy |
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Derinat 0.25% solution for local and external use 10 ml 1 pc. 208 RUB Buy |
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Derinat 0.25% solution for local and external use 10 ml 1 pc. 239 r Buy |
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Derinat solution of places. and outside. approx. 0.25% dropper bottle 10 ml 262 RUB Buy |
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Derinat 0.25% solution for local and external use 10 ml 1 pc. 320 RUB Buy |
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Derinat spray solution outside. approx. 0.25% 10ml 375 RUB Buy |
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Derinat (for injection) 1.5% solution for intramuscular injection 5 ml 5 pcs. 1529 RUB Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
