Gynofort
Gynofort: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacodynamics and pharmacokinetics
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application in children
- 10. Pregnancy and lactation period
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Gynofort
ATX code: G01AF15
Active ingredient: Butoconazole (Butoconazole)
Manufacturer: KB Pharmaceutical Co. (USA), Gedeon Richter (Hungary)
Description and photo update: 2019-05-08
Prices in pharmacies: from 500 rubles.
Buy
Gynofort is an imidazole derivative, antifungal agent with fungicidal action, active against fungi of the genus Microsporum, Trichophyton, Epidermophyton and Candida.
Release form and composition
Dosage form - vaginal cream: homogeneous, without visible stratification and foreign particles, from white to white with a gray tint (5 g each in polypropylene applicators, 1 applicator in a polystyrene box, 1 box in a laminated bag, 1 bag in a cardboard box).
Active ingredient: butoconazole nitrate, in 1 g of cream - 20 mg.
Additional components: polyglyceryl-3-oleate, glycerol monostearate, wax, mineral oil, colloidal silicon dioxide, propyl parahydroxybenzoate, methyl parahydroxybenzoate, propylene glycol, disodium edetate, sorbitol, water.
Pharmacodynamics and pharmacokinetics
Gynofort refers to antimycotic drugs that are used in gynecology for the local treatment of vaginal infections caused by fungi.
Butoconazole - the active substance of the drug - is an imidazole derivative and has a fungicidal effect. It is fatal to fungal strains of the genus Epidermophyton (athlete's foot), Candida (thrush), Microsporum (ringworm), Trichophyton (trichophytosis). The drug blocks the transformation of lanosterol into ergosterol in the cell membrane of the fungus and increases the permeability of the membrane, promoting the lysis (decay) of fungal cells.
The bioadhesiveness of the cream is quite high. With a single intravaginal use of the drug, butoconazole is determined on the vaginal mucosa for 4-5 days.
Systemic absorption of butoconazole when the drug is injected into the vagina is 1.7% of the recommended dose. The maximum plasma concentration of this substance is 2–18.6 ng / ml and is reached 13 hours after the drug is administered.
In the body, butoconazole is extensively metabolized and undergoes partial excretion through the kidneys and intestines.
Indications for use
Gynofort is used to treat vaginal candidiasis caused by Candida albicans.
Contraindications
The use of the drug is contraindicated in girls under 18 years of age, pregnant and breastfeeding women, as well as all patients with hypersensitivity to its components.
Instructions for the use of Gynofort: method and dosage
Gynofort is intended for single intravaginal use.
The contents of 1 applicator are inserted deep into the vagina.
The time of day of the drug use does not matter.
Rules for using the disposable applicator:
- Remove foil from packaging;
- Remove the applicator;
- Without removing the cap, take the applicator firmly with one hand, and with the other pull the ring to the limit in order to pull the piston out of it;
- Gently insert the applicator deep into the vagina;
- Slowly pressing the plunger, squeeze out the cream;
- Remove empty applicator and discard.
Side effects
- Local reactions: soreness, itching, burning, swelling of the vaginal wall;
- Others: cramps and / or pain in the lower abdomen.
Overdose
Cases of overdose with topical application of the drug are currently not known. In case of accidental swallowing (oral ingestion) of the contents of the applicator, you should cleanse the digestive tract (rinse the stomach and intestines) and undergo a course of symptomatic therapy.
special instructions
The applicator is intended for single use.
Do not heat the applicator and use if the cap is removed.
The preparation contains parabens that can cause allergic reactions.
If, after the end of treatment, clinical signs of infection persist, it is necessary to conduct a second microbiological study to identify the pathogen and confirm the diagnosis.
In case of painful sensations or irritation of the vaginal mucosa, treatment should be discontinued.
In case of accidental ingestion of Gynofort cream into the gastrointestinal tract, it is necessary to wash the stomach and, if necessary, carry out symptomatic treatment.
The drug does not have a negative effect on attention and reaction speed.
Application in children
It is prohibited to use Gynofort in pediatric practice.
Pregnancy and lactation
Although, according to the official instructions, Ginofort is contraindicated in pregnant and lactating mothers, in some cases it is prescribed to patients with diagnosed vaginal candidiasis. Previously, the specialist must carefully weigh the ratio of the benefits to the mother and the likely risks to the fetus or child and warn the patient about the possible consequences of such therapy.
Drug interactions
The preparation contains mineral oil, which can damage rubber and latex products (including intravaginal diaphragms and condoms), therefore, it is not recommended to use these contraceptives within 72 hours after the injection of Gynofort cream.
There is no information on interactions with other medicinal products.
Analogs
Analogs of Ginofort are: Ginalgin, Zalain, Gainomax, Vagiferon, Kandibene, Metronidazole, Candide, Vagisept, Metrogyl, Clotrimazole, Mikogal, Candizol, Neo-Penotran, Trichopol, Orniona, Funginal.
Terms and conditions of storage
Store at a temperature of 15-25 ° С out of the reach of children.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Gynofort
In most cases, reviews of Gynofort are favorable. It effectively fights vaginal candidiasis, including in pregnant women. The drug is characterized by high efficiency of treatment, rare and minor manifestations of side effects and ease of use due to single use. Some patients speak negatively about the drug, noting its high cost.
Price for Gynofort in pharmacies
The price of Gynofort in pharmacies varies from 630 to 850 rubles (per pack containing 1 applicator with 20 mg of active ingredient).
Gynofort: prices in online pharmacies
|
Drug name Price Pharmacy |
|
Gynofort 20 mg / g vaginal cream 5 g 1 pc. RUB 500 Buy |
|
Gynofort cream vaginal. 2% 5g 621 RUB Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
