Ginatren
Ginatren: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Pharmacodynamics
- 4. Indications for use
- 5. Contraindications
- 6. Method of application and dosage
- 7. Side effects
- 8. Overdose
- 9. Special instructions
- 10. Application during pregnancy and lactation
- 11. Use in childhood
- 12. In case of impaired renal function
- 13. Drug interactions
- 14. Analogs
- 15. Terms and conditions of storage
- 16. Terms of dispensing from pharmacies
- 17. Reviews
- 18. Price in pharmacies
Latin name: Gynatren
ATX code: J07A
Active ingredient: deactivated microorganisms specific Lactobacillus
Manufacturer: Strathmann, GmbH & Co. KG (Strathmann, GmbH & Co. KG) (Germany)
Description and photo update: 2019-10-07
Ginatren is a vaccine that restores the damaged vaginal microbiome.
Release form and composition
The drug is produced in the form of a suspension for intramuscular (i / m) injections (0.5 ml in an ampoule, in a cardboard box of 3, 4, 12, 30, 36 or 40 ampoules and instructions for the use of Ginatren).
In 0.5 ml of the drug (the contents of 1 ampoule), the active ingredient is deactivated microorganisms: 8 strains of specific lactobacilli in equal proportions (Lactobacillus salivarius and Lactobacillus fermentum - 1 strain each; Lactobacillus vaginalis and Lactobacillus rhamnosus - 3 strains in total) × 10 9.
Perhaps the absence of the listed or the presence of other forms of packaging.
Pharmacological properties
Pharmacodynamics
Ginatren is an immunostimulating drug, after the use of which specific and non-specific IgG antibodies (immunoglobulins G) are produced. It promotes the stimulation of polyclonal B-lymphocytes and increases the activity of macrophages. Due to the activation of antibodies, the elimination of opportunistic microorganisms is carried out, including gardnerella, which have a detrimental effect on the vaginal microflora and lead to constant exacerbations of bacterial vaginitis.
The drug eliminates the disorders that accompany relapses of the inflammatory disease, such as itching, burning sensation in the vaginal area, the appearance of leucorrhoea and an unpleasant odor. Also, vaccination prevents the development of relapses of trichomoniasis and reduces the risk of re-infection with pathogenic bacteria.
As a result of the action of the drug, the growth of vaginal lactobacilli (Dederlein sticks) occurs, which ensures a quick restoration of the normal bacterial flora and helps in achieving the pH of the vaginal mucosa of the physiological norm. Thus, Ginatren demonstrates a local effect and protects for a long time against the occurrence of relapses and reinfection of diseases.
Pharmacokinetics
The pharmacokinetics of the drug have not been studied.
Indications for use
Immunization with the drug is recommended for women and girls over 15 years old with the following diseases:
- bacterial vaginitis with frequent relapses;
- recurrent trichomoniasis.
Contraindications
- acute infectious lesions;
- active tuberculosis;
- severe disorders of hematopoiesis;
- acute febrile illness;
- immunodeficiency states;
- functional failure of the kidneys and / or heart;
- damage to the immune system (autoimmune and immunoproliferative diseases);
- pregnancy and lactation;
- age up to 15 years;
- hypersensitivity to the ingredients of the drug.
Ginatren, instructions for use: method and dosage
The Ginatren vaccine is injected intramuscularly deeply slowly, preferably into the deltoid muscle of the shoulder.
The ampoule with the drug is vigorously shaken before opening. The turbidity of the solution observed in this case is the norm, since the active ingredient is not dissolved in it, but is evenly distributed in the form of particles.
The suspension is required to be used immediately after opening the ampoule. The liquid is drawn into a syringe with a needle, and then another needle is used for injection to avoid local damage.
The main vaccination should be carried out by three times injecting a suspension of 0.5 ml (contents of 1 ampoule) with an interval of 14 days. Re-immunization is carried out with the drug Booster-Ginatren after 6-12 months at a dose of 0.5 ml of suspension once.
These procedures provide protection from the development of recurrence of bacterial infections for 2 years, there may also be a longer or shorter period of immune protection. If necessary, reactivation is carried out with Booster-Ginatren after 24 months at a dose of 0.5 ml 1 time.
Side effects
When using Ginatren, the following negative side effects may develop:
- local reactions: redness, swelling, soreness, or a feeling of tension at the injection site;
- vaccination reactions: general fatigue, weakness; flu-like symptoms in the form of weakness, headache and muscle pain, fever with chills, soreness in the limbs; malaise, dizziness, nausea, swollen lymph nodes; rarely - gastrointestinal disorders, cough, itching, rash, respiratory distress, anaphylactic reactions, cardiovascular disorders (up to collapse); neurological symptoms.
Overdose
In the course of preclinical studies in rodents, with a thousand-fold excess of the dose of the drug, negative effects were not recorded. There are no data on overdose in humans.
special instructions
Since with the introduction of Ginatren there is a risk of developing anaphylactic reactions, vaccination should be carried out only in a medical institution or under the supervision of an experienced health worker.
Influence on the ability to drive vehicles and complex mechanisms
During the vaccination period, care must be taken when driving and maintaining complex machinery.
Application during pregnancy and lactation
Pregnancy and lactation are absolute contraindications for the use of Ginatren.
Pediatric use
The use of the Ginatren vaccine is contraindicated in girls and girls under 15 years of age.
With impaired renal function
In case of renal failure, the use of the drug is contraindicated.
Drug interactions
The effect of Ginatren can be reduced with the combined conduct of radiation therapy or the use of immunosuppressants.
Analogs
SolkoTrichovak is an analogue of Ginatren.
Terms and conditions of storage
Store at 2–8 ° C without freezing. At room temperature (not exceeding 25 ° C), the solution can be stored for no more than 48 hours.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Ginatren
According to reviews, Ginatren is an effective vaccine against bacterial vaginitis with persistent exacerbations and recurrent trichomoniasis. The drug, in the opinion of patients and doctors, reliably helps to reduce the frequency of recurrence of bacterial infection and reduce the threat of re-infection with pathogenic microorganisms.
The disadvantages include the absence of Ginatren on sale in pharmacies and its rather high cost when ordered through intermediaries.
Price for Ginatren in pharmacies
There is no reliable information about the price of Ginatren, since the drug is currently not available in the pharmacy chain.
Today, you can purchase a vaccine only through online pharmacies that deliver medicines from Europe. The approximate cost of a package of Ginatren containing 3 ampoules of 0.5 ml of suspension is 8850–9950 rubles.
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
