Gelmodol-VM - Instructions For Use, Indications, Doses, Analogues

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Gelmodol-VM

Instructions for use:

1. 1. Release form and composition
2. 2. Indications for use
3. 3. Contraindications
4. 4. Method of application and dosage
5. 5. Side effects
6. 6. Special instructions
7. 7. Drug interactions
8. 8. Analogs
9. 9. Terms and conditions of storage
10. 10. Terms of dispensing from pharmacies

Gelmodol-VM is a drug with an anthelmintic and antiprotozoal effect, used to treat most existing helminthiases.

Release form and composition

Dosage form - film-coated tablets: convex on both sides, round, almost white or white, with a characteristic odor; the section shows a white core (2 pcs. in PVC / aluminum foil blisters, 1 blister in a cardboard box).

The active substance and its content in each tablet: albendazole (micronized) - 200 mg.

Additional components:

• excipients: corn starch, sodium lauryl sulfate, magnesium stearate, lactose monohydrate, sodium carboxymethyl starch, povidone, crospovidone;
• shell composition: titanium dioxide, macrogol, purified talc, hypromellose.

Indications for use

Gelmodol-VM is used to treat the following nematodes:

• ascariasis caused by the round helminth Ascaris lumbricoides;
• enterobiasis (pinworms) caused by the round helminth Enterobius vermicularis;
• trichinosis caused by Trichinella spiralis;
• strongyloidosis (intestinal acne) caused by the round helminth Strongyloides stercoralis, as well as mixed infestations;
• toxocariasis caused by Toxocara canis;
• ankylostomiasis (crooked heads) caused by Ancylostoma duodenale and Necator americanus;
• trichocephalosis (whipworm) caused by the round helminth Trichocephalus trichiurus.

Gelmodol-VM is used to treat the following tissue cestodoses:

• hydatid echinococcosis of the peritoneum, lungs and liver, caused by the larval form of the canine tapeworm (Echinococcus granulosus);
• neurocysticercosis caused by the larval form of the tapeworm parasite of the pork tapeworm (Cysticercus cellulosae).

Also, the drug is used as part of complex therapy in the surgical treatment of alveolar echinococcosis caused by Echinococcus multilocularis.

Contraindications

• retinal pathology;
• lactase deficiency, lactose intolerance, glucose-galactose malabsorption;
• children under 3 years old;
• pregnancy, breastfeeding period;
• hypersensitivity to any component of the drug or other benzimidazole derivatives.

Gelmodol-VM should be used with caution in liver cirrhosis, inhibition of bone marrow hematopoiesis, liver dysfunction.

Method of administration and dosage

The drug is intended for oral administration. The tablets should be taken with or after meals.

Doses are selected individually depending on the type of helminthic invasion and the patient's body weight.

Unless otherwise prescribed by your doctor, the following treatment regimens apply:

• enterobiasis: adults and children from 3 years old - 400 mg once, after 14 days the drug is taken in the same dose;
• strongyloidosis, ankylostomiasis: adults and children from 3 years old - 400 mg once a day for 3 days, after 7 days a second course of treatment is carried out;
• trichinosis: 400 mg 2 times a day for 10-14 days. With severe invasion and with organ lesions (pneumonitis, myocarditis, meningoencephalitis), glucocorticosteroids and symptomatic agents are additionally prescribed;
• nematodes, including nematosis, ascariasis and trichocephalosis: patients weighing from 60 kg - 200 mg 2 times a day or 400 mg a day once, patients weighing less than 60 kg - 15 mg / kg / day in 1 or 2 doses;
• toxocariasis: adults and adolescents over 14 years old with a body weight of more than 60 kg - 400 mg each (with a body weight less than 60 kg - 200 mg each) 2 times a day for a course of 10 days. With an interval of 2-4 weeks, repeated courses are carried out. During treatment (every 5-7 days), peripheral blood and liver enzyme activity are monitored;
• neurocysticercosis: patients weighing from 60 kg - 400 mg 2 times a day, patients weighing less than 60 kg - 15 mg / kg in 2 divided doses. The course of treatment is 28-30 days (2 days before Gelmodol-VM, glucocorticosteroids are prescribed, which continue to be taken during the first week of therapy);
• hydatid echinococcosis: patients weighing from 60 kg - 400 mg 2 times a day, patients weighing less than 60 kg - 15 mg / kg in 2 divided doses. The course of treatment consists of 3 cycles of 28 days with intervals of 14 days;
• giardiasis: 400 mg 1 time per day for a course of 3 days, children weighing less than 10 kg - 200 mg 1 time per day for 5 days;
• mixed invasions: 400 mg 2 times a day for 3 days. If necessary, repeat the course of treatment in a month.

The maximum daily dose is 800 mg.

Side effects

• cardiovascular system: increased blood pressure;
• urinary system: changes in renal function indicators, acute renal failure;
• hematopoietic system: suppression of bone marrow activity, aplastic anemia, neutropenia, suppression of bone marrow hematopoiesis (agranulocytosis, pancytopenia, granulocytopenia, leukopenia, thrombocytopenia);
• skin: skin rash, itching, Steven-Johnson syndrome, erythema multiforme;
• central nervous system: increased intracranial pressure, dizziness, headache, meningeal symptoms;
• digestive system: abdominal pain, dry mouth, anorexia, epigastric pain, diarrhea / constipation, nausea, vomiting, liver dysfunction with changes in liver function tests (mild or moderate increase in liver transaminase activity), hepatitis, acute liver failure;
• allergic reactions: immediate-type hypersensitivity reactions, angioedema;
• others: alopecia, hyperthermia.

special instructions

Before the appointment of Gelmodol-VM, it is necessary to carry out a clinical blood test and a biochemical blood test. The drug can be used only under the condition of normal laboratory parameters.

Every 5-7 days during therapy, blood and aminotransferases should be tested. In the event that the level of leukocytes is below the normal 3.0x10 ⁹ or the activity of aminotransferases is increased by 2 times, the drug should be temporarily discontinued until laboratory values return to the level that was observed before the start of treatment.

The use of hepatoprotective drugs during therapy, including in the case of toxic manifestations, is ineffective, therefore, the drug must be canceled.

It is also recommended to monitor the cellular composition of the blood during treatment. In case of leukopenia, Gelmodol-VM is canceled.

With neurocysticercosis affecting the tissues of the eyes, it is necessary to examine the retina before starting therapy, since there is a risk of aggravating its pathology.

For women of childbearing age, the drug is prescribed only after excluding pregnancy. During treatment, you should use reliable methods of contraception.

It is recommended to avoid the use of Gelmodol-VM in high doses for the treatment of children for a long period.

Before starting therapy with albendazole, like any other anthelmintic agent, you should thoroughly clean the apartment, wash children's toys, take a shower before and after sleep and change your underwear. During the treatment and for several days after its completion, it is recommended to iron the bed linen with a hot iron.

In the case of the appointment of Gelmodol-VM to patients who receive theophylline, it is necessary to control the plasma concentration of the latter.

Due to the risk of side effects during the period of therapy, you should refrain from eating grapefruit.

Albendazole can cause dizziness, therefore, patients should refrain from driving a car and performing potentially dangerous types of work that require speed of psychomotor reactions and increased attention during treatment.

Drug interactions

Cimetidine, praziquantel and dexamethasone increase the concentration of albendazole sulfoxide in the blood.

With the simultaneous use of theophylline, the risk of nausea, vomiting, heart palpitations and seizures increases.

Carbamazepine, phenobarbital, common ginseng, phenytoin can reduce the concentration of albendazole in the intestine.

Analogs

Analogs of the drug Gelmodol-VM are: Sanoxal and Nemozol.

Terms and conditions of storage

Keep out of the reach of children. Observe the temperature regime 15-25 ° С.

The shelf life is 3 years.

Terms of dispensing from pharmacies

Dispensed by prescription.

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!