Gastrozole
Gastrozole: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological action
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Drug interactions
- 10. Analogs
- 11. Terms and conditions of storage
- 12. Terms of dispensing from pharmacies
- 13. Reviews
- 14. Price in pharmacies
Latin name: Gastrozol
ATX code: A02BC01
Active substance: omeprazole
Producer: JSC "Pharmstandard-Leksredstva" (Russia)
Description and photo update: 2019-07-08
Prices in pharmacies: from 72 rubles.
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Gastrozole is a proton pump inhibitor, antiulcer drug.
Release form and composition
Dosage form - capsules: size No. 2, hard gelatinous, opaque, body - light pink, lid - pinkish-brown; content - white or almost white pellets (7 or 10 pcs. in contoured non-cell packs, 1 or 2 packs in a cardboard box; 10, 14 or 28 pcs. in polymer cans, 1 can in a cardboard box).
Active ingredient: omeprazole, 1 capsule - 20 mg.
Additional components: calcium carbonate, sodium hydrogen phosphate (disodium phosphate disubstituted), lactose, sodium lauryl sulfate, hypromellose (hydroxypropyl methylcellulose), sucrose, methacrylic acid and ethyl acrylate copolymer (copolymer of methacrylic acid L30D), cetyl alcohol, sodium diethylphthalate 80 (tween-80), titanium dioxide, povidone (polyvinylpyrrolidone), talc, mannitol.
The composition of the capsule (body and cap): gelatin, methyl parahydroxybenzoate (methylhydroxybenzoate), titanium dioxide (E171), propyl parahydroxybenzoate (propylhydroxybenzoate), iron oxide red (E172); or gelatin, titanium dioxide (E171) and iron oxide red (E172).
pharmachologic effect
Pharmacodynamics
Gastrozole is a proton pump inhibitor and reduces the production of gastric acid by suppressing the activity of H + / K + -ATPase in the parietal cells of the stomach, as a result of which the final stage of hydrochloric acid is blocked. The drug belongs to prodrugs and is activated in an acidic environment, characteristic of the secretory tubules of parietal cells.
Omeprazole reduces stimulated and basal secretion regardless of the type of stimulus. After taking 20 mg of Gastrozol, the antisecretory effect appears within the first hour (maximum - after 2 hours). Maximum secretion is inhibited by 50% for 24 hours. A single intake of a daily dose of the drug guarantees a quick and effective suppression of the day and night secretion of the gastric glands, which reaches a maximum after 4 days of treatment and disappears 3-4 days after completion of the course of therapy. In patients with duodenal ulcer, taking 20 mg of Gastrozole stabilizes the intragastric acidity (pH) at 3.0 for 17 hours.
Pharmacokinetics
The drug is characterized by a high degree of absorption, and its maximum concentration in the body is observed 0.5–3.5 hours after oral administration. Bioavailability is 30-40%, with hepatic insufficiency, increasing to almost 100%. The active component of the drug has increased lipophilicity and freely penetrates into the parietal cells of the stomach, binding to plasma proteins (albumin and acidic α 1 -glycoprotein) by 90–95%.
The half-life of omeprazole is 0.5-1 hour (with hepatic dysfunctions - 3 hours), and the clearance reaches 500-600 ml / min. The active substance of Gastrozole is almost completely metabolized in the liver under the influence of the CYP2C19 enzyme system, forming 6 pharmacologically inactive metabolites (hydroxyomeprazole, sulfone and sulfide derivatives, etc.). The drug belongs to the group of inhibitors of the isoenzyme CYP2C19 and is excreted through the kidneys (70–80%) and in the bile (20–30%). Chronic renal failure reduces excretion in proportion to the decrease in creatinine clearance. In elderly patients, the bioavailability of omeprazole increases, and the rate of its excretion decreases.
Indications for use
- Exacerbation of gastric ulcer and 12 duodenal ulcer;
- Reflux esophagitis;
- Gastropathy induced by the use of non-steroidal anti-inflammatory drugs (NSAID-gastropathy);
- Hypersecretory conditions (polyendocrine adenomatosis, stress ulcers of the gastrointestinal tract, systemic mastocytosis, Zollinger-Ellison syndrome);
- Helicobacter pylori infection in patients with gastric ulcer and 12 duodenal ulcer (as part of complex therapy).
Also, the drug is used for the prevention of gastric ulcer and 12 duodenal ulcer.
Contraindications
- Childhood;
- Pregnancy;
- Lactation;
- Hypersensitivity to the drug.
Gastrozole should be used with caution in hepatic and / or renal failure.
Instructions for the use of Gastrozol: method and dosage
The drug is taken orally, swallowing the capsules whole and drinking a small amount of water, usually in the morning, just before meals or during meals.
Recommended doses depending on indications:
- Exacerbation of duodenal ulcer: 1 capsule per day for 2-4 weeks, if necessary, the dose is increased to 2 capsules;
- Exacerbation of duodenal ulcer and erosive-ulcerative esophagitis: 1-2 capsules per day for 4-8 weeks;
- NSAID gastropathy: 1 capsule per day for 4-8 weeks;
- Helicobacter pylori infection: 1 capsule 2 times a day in combination with antibacterial agents, course - 7 days;
- Zollinger-Ellison syndrome: the dose is set individually, depending on the initial level of gastric secretion. The initial dose is usually 3 capsules per day, if necessary, it is increased to 4-6 capsules and the dose is divided into 2 doses;
- Prevention of relapses of gastric ulcer and 12 duodenal ulcer: 1 capsule per day;
- Prevention of relapses of reflux esophagitis: 1 capsule per day for a long time (up to 6 months).
Side effects
- Digestive system: diarrhea / constipation, flatulence, nausea, vomiting, abdominal pain; rarely - taste disturbances, increased activity of hepatic transaminases, the formation of gastric glandular cysts with prolonged treatment (are reversible and benign); in some cases - stomatitis, dry mouth; in patients with previous severe liver disease - liver dysfunction, hepatitis (including jaundice);
- Musculoskeletal system: in some cases - myasthenia gravis, arthralgia, myalgia;
- Central and peripheral nervous system: in patients with concomitant severe somatic diseases - agitation, headache, depression, dizziness; in patients with previous severe liver disease - encephalopathy;
- Hematopoietic system: in some cases - agranulocytosis, thrombocytopenia, pancytopenia, leukopenia;
- Dermatological reactions: rarely - rash and / or itching of the skin; in some cases - alopecia, photosensitization, exudative erythema multiforme;
- Allergic reactions: fever, urticaria, bronchospasm, angioedema, anaphylactic shock, interstitial nephritis;
- Others: blurred vision, malaise, peripheral edema, gynecomastia, increased sweating.
Overdose
A single oral intake of Gastrozole in doses not exceeding 400 mg (2 capsules) did not lead to any severe symptoms. A single intake of omeprazole at a dose of 560 mg in adult patients was accompanied by signs of moderate intoxication. Increasing the dose did not change the rate of drug elimination and did not require specific treatment.
Overdose symptoms are: nausea, vomiting, flatulence, diarrhea, headache, dizziness, blurred consciousness, apathy, vascular dilatation, tachycardia. In this case, symptomatic treatment and the intake of activated carbon are prescribed, if necessary, the stomach is washed.
special instructions
Before prescribing Gastrozole, it is necessary to examine the patient in order to exclude the presence of a malignant process, especially with gastric ulcer, since omeprazole can mask the symptoms and thereby delay the timely establishment of the correct diagnosis.
Food intake does not affect the effectiveness of the drug.
Influence on the ability to drive vehicles and complex mechanisms
Since treatment can be accompanied by such side effects as drowsiness, dizziness and blurred vision, when driving or when working with complex mechanisms that require increased concentration and immediate psychomotor reactions, care must be taken.
Drug interactions
Omeprazole increases the pH of the stomach, so it can reduce the absorption of ketoconazole, itraconazole, iron salts and ampicillin esters.
Omeprazole is an inhibitor of isoenzymes of the cytochrome P 450 system, therefore, it can increase the plasma concentration and reduce the excretion of drugs metabolized in the liver with the participation of CYP2C19 (for example, phenytoin), indirect anticoagulants and diazepam. For this reason, it may be necessary to reduce the doses of these medicines.
According to the instructions, Gastrozol enhances the inhibitory effect of other drugs on the hematopoietic system.
Analogs
Analogues of Gastrozol are: Zipantol, Helikol, Zulbeks, Krosatsid, Controloc, Lanzabel, Nexium, Lanzap, Nolpaza, Lanzoptol, Lancid, Ontaym, Peptazol, Pantaz, Sanpraz, Epikur, Ultera, Rabelok, Pantera, Netoprazo-Esozol Omeprazole, Losec, Omeprus, Omez, Omecaps, Omefez, Omipiks, Ortanol, Omizak, Promez, Sopral, Romesek, Ulkozol, Helicid, Ultop, Cisagast.
Terms and conditions of storage
Store at temperatures up to 25 ºС. Do not expose to light and moisture. Keep out of the reach of children.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Gastrozol
According to reviews, Gastrozole is a fairly effective treatment for all conditions indicated in its indications for use. However, some patients complain of side effects while taking the drug, expressed in headache, nausea, abdominal pain and allergic reactions. But it is worth considering that all these symptoms are often mild or disappear on their own at the next stages of therapy. Also, patients note the rather high cost of Gastrozole compared to its counterparts, also containing omeprazole.
Price for Gastrozole in pharmacies
The price of Gastrozole in a package containing 14 capsules in pharmacies is 80–110 rubles. You can buy the drug in a package containing 28 capsules for 150-165 rubles.
Gastrozole: prices in online pharmacies
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Drug name Price Pharmacy |
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Gastrozole 10 mg enteric capsules 14 pcs. RUB 72 Buy |
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Gastrozole capsules intestinal. 10mg 14 pcs. RUB 81 Buy |
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Gastrozole 20 mg enteric capsules 14 pcs. RUB 88 Buy |
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Gastrozole capsules 20mg 14 pcs. 94 r Buy |
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Gastrozole 10 mg enteric capsules 28 pcs. 132 RUB Buy |
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Gastrozole capsules intestinal. 10mg 28 pcs. 135 RUB Buy |
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Gastrozole 20 mg enteric capsules 28 pcs. 152 RUB Buy |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
