Vankorus

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Instructions for use:

1. Release form and composition
2. Indications for use
3. Contraindications
4. Method of application and dosage
5. Side effects
6. Special instructions
7. Drug interactions
8. Analogs
9. Terms and conditions of storage
10. Terms of dispensing from pharmacies

Prices in online pharmacies:

from 303 rub.

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Lyophilisate for the preparation of solution for infusion Vankorus

Vankorus is an antibacterial drug from the group of glycopeptides.

Release form and composition

Dosage form - lyophilisate for preparing a solution for infusion: powder from white to white with a light brown or pink tint (500 mg - in 10 ml vials, 1000 mg - in 20 ml vials; 1 vial in a cardboard box, 50 vials in a cardboard box).

Active ingredient: vancomycin (in the form of hydrochloride), in 1 bottle - 500 or 1000 mg.

Auxiliary component: mannitol.

Indications for use

Vankorus is used to treat the following infectious and inflammatory diseases caused by microorganisms sensitive to vancomycin:

lower respiratory tract infections (pneumonia, lung abscess);
meningitis;
sepsis;
endocarditis;
infections of the skin and soft tissues;
infections of bones and joints, including osteomyelitis.

Inside the solution is prescribed for diseases such as:

enterocolitis caused by Staphylococcus aureus;
pseudomembranous colitis caused by Clostridium difficile.

Contraindications

Absolute:

neuritis of the auditory nerve;
I trimester of pregnancy;
period of breastfeeding;
hypersensitivity to Vancorus components.

Relative:

hearing impairment;
renal failure;
allergy to teicoplanin;
II and III trimesters of pregnancy.

Method of administration and dosage

Intravenous administration

The solution is administered as a slow (at least 60 minutes) intravenous infusion at a rate of up to 10 mg / minute.

The injection solution is prepared immediately before administration: sterile water for injection is added to the vial with the lyophilisate - 10 ml at a dose of 500 mg, 20 ml at a dose of 1000 mg. The concentration of the finished solution is 50 mg vancomycin per ml.

Before administration, the solution is subject to further dilution to a concentration of no more than 5 mg / ml.

As solvents, you can use a solution of sodium chloride 0.9% or a solution of dextrose (glucose) 5%: 100 ml - at a dose of 500 mg, 200 ml - at a dose of 1000 mg.

Recommended doses:

newborns up to 7 days of life - at the beginning of therapy, 15 mg / kg, then 10 mg / kg every 12 hours;
children 2-4 weeks of age - 10 mg / kg every 8 hours;
children from 1 month and older - 10 mg / kg every 6 hours;
adults - 500 mg (7.5 mg / kg) every 6 hours or 1000 mg (15 mg / kg) every 12 hours.

In case of impaired renal excretory function, the interval between injections is increased or the dose of Vankorus is adjusted, depending on the creatinine clearance (CC, ml / minute).

Correction by increasing the intervals between injections when prescribing a single dose of 1000 mg:

CC> 80 ml / min - interval 12 hours;
CC 50–80 ml / min - interval 1–3 days;
CC 10-50 ml / min - interval 3-7 days;
CC <10 ml / min - interval 7-14 days.

Correction of a single dose of Vankorus:

CC 100 ml / min - 1545 mg / day;
CC 90 ml / min - 1390 mg / day;
CC 80 ml / min - 1235 mg / day;
CC 70 ml / min - 1080 mg / day;
CC 60 ml / min - 925 mg / day;
CC 50 ml / min - 770 mg / day;
CC 40 ml / min - 620 mg / day;
CC 30 ml / min - 465 mg / day;
CC 20 ml / min - 310 mg / day;
CC 10 ml / min - 155 mg / day.

These recommendations for dose adjustment should not be followed in the presence of anuria. For such patients, the drug is prescribed at an initial dose of 15 mg / kg in order to quickly achieve a therapeutic serum concentration. The maintenance dose is 1.9 mg / kg per day.

In case of severe renal failure, it is advisable to use Vankorus in a maintenance dose of 250–1000 mg at intervals of several days.

With anuria, 1000 mg is usually prescribed every 7-14 days.

If only the serum creatinine concentration is known, the following formula is used to calculate the clearance:

for men: CC = body weight (kg) × [140 - age (years)] / 72 × serum creatinine concentration (mg / dl);
for women: the result should be multiplied by 0.85.

Oral intake

With pseudomembranous colitis caused by Clostridium difficile, due to the use of antibiotics, as well as with staphylococcal enterocolitis, Vankorus is prescribed orally.

A solution for oral administration is prepared as follows: a single dose of the drug is dissolved in 30 ml of water. To improve the taste, it is possible to add food syrups. If it is impossible to take the drug inside, it is administered through a tube.

Recommended daily doses:

adults - 500-2000 mg;
children - 40 mg / kg.

The daily dose should be divided into 3-4 doses.

The highest daily dose for adults and children is 2000 mg.

The duration of therapy is 7-10 days.

Side effects

on the part of the hematopoietic organs: transient thrombocytopenia, reversible neutropenia, agranulocytosis;
from the gastrointestinal tract: nausea, pseudomembranous colitis;
from the urinary system: interstitial nephritis, nephrotoxicity up to the development of renal failure [more often with prolonged use (more than 3 weeks) in high doses or in combination with aminoglycosides; manifested by an increase in the concentration of creatinine and urea nitrogen in the blood];
from the senses: ototoxicity - vertigo, hearing loss, ringing in the ears;
allergic reactions: rash (including exfoliative dermatitis), chills, fever, eosinophilia, vasculitis, toxic epidermal necrolysis, malignant exudative erythema;
local reactions (in case of violation of the infusion rules): pain and tissue necrosis at the injection site, phlebitis;
post-infusion reactions (due to rapid administration): “red man's” syndrome (hyperemia of the upper half of the trunk and face, palpitations, fever, chills, spasm of the muscles of the chest and back), anaphylactoid reactions (skin rash, itching, dyspnoea, bronchospasm, lowering blood pressure, cardiac arrest).

special instructions

The drug should be used only in a hospital setting.

Vankorus should not be injected intravenously or intramuscularly.

The frequency and severity of thrombophlebitis can be reduced due to the correct dilution of the initial solution and the alternation of the injection sites.

With long-term treatment, control of renal function (general urine analysis, creatinine and blood urea nitrogen), monitoring of the peripheral blood picture, and audiogram are shown.

In infants and premature infants during treatment, it is necessary to constantly monitor the concentration of vancomycin in the blood plasma.

The serum level of the drug should be monitored in patients aged 60 years and older with renal failure, since this category of patients has a high risk of developing the toxic effect of the drug.

Drug interactions

Vancomycin has a low pH level, which can cause physical or chemical instability when mixed with other solutions. Do not mix the drug with alkaline solutions.

Vankorus is physically incompatible with beta-lactam antibiotics. Between the use of these antibiotics and vancomycin, the intravenous system should be thoroughly flushed, since the likelihood of precipitation increases with increasing vancomycin concentration.

Meclosine, phenothiazines, antihistamines, and thioxanthenes may mask symptoms of vancomycin ototoxicity (vertigo and tinnitus).

With the simultaneous and / or sequential use (both systemic and local) of other potentially nephrotoxic and / or ototoxic agents, it is necessary to carefully monitor the patient's condition for the development of these symptoms. This applies, inter alia, to the following drugs: aminosalicylic acid or other salicylates, cyclosporin, capreomycin, aminoglycosides, carmustine, amphotericin B, loop diuretics, including ethacrynic acid, cisplatin, polymyxin B.

Cholestyramine reduces the effectiveness of vancomycin when taken orally.

Analogs

Vancorus analogs are: Editsin, Vankocin, Vancomycin-Teva, Vancomycin DZh.

Terms and conditions of storage

Keep out of the reach of children, protected from light and in a dry place at temperatures up to 25 ° C.

Shelf life is 2 years.

Solutions prepared on the basis of 0.9% sodium chloride solution and 5% dextrose (glucose) solution can be stored for 14 days at 2–8 ° C (in the refrigerator).

Terms of dispensing from pharmacies

Dispensed by prescription.

Vankorus: prices in online pharmacies

Drug name

Price

Pharmacy

Vankorus 1 g lyophilisate for preparation of solution for infusion 1 pc.

303 RUB

Buy

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!