Validol Avexima
Validol Avexima: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Use in childhood
- 10. Drug interactions
- 11. Analogs
- 12. Terms and conditions of storage
- 13. Terms of dispensing from pharmacies
- 14. Reviews
- 15. Price in pharmacies
Latin name: Validol Avexima
ATX code: C01EX
Active ingredient: Levomenthol solution in menthyl isovalerate + dextrose (Dextrose)
Producer: JSC "Irbitskiy Khimfarmzavod" (Russia)
Description and photo update: 2020-24-06
Prices in pharmacies: from 32 rubles.
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Validol Avexima is a reflex vasodilator drug.
Release form and composition
The drug is produced in the form of sublingual tablets: white or white with gray splashes of color, flat-cylindrical, with a chamfer and a risk, with a characteristic smell of menthol (10 pcs. In a blister strip, in a cardboard box 1 or 2 packages and instructions for use of Validol Avexim; for hospitals - 1000 packs in a cardboard box).
1 tablet contains:
- active substances: levomenthol solution in menthil isovalerate (Validol) - 60 mg, dextrose monohydrate (glucose monohydrate) - 188 mg;
- additional components: stearic acid, colloidal silicon dioxide (aerosil), sugar (sucrose).
Pharmacological properties
Pharmacodynamics
Validol Avexima has a sedative effect, has a moderate reflex vasodilator effect caused by irritation of sensitive nerve endings. The drug stimulates the production and release of endorphins, enkephalins and some other peptides, as well as kinins (due to their effect on mucosal receptors), which play an important role in the regulation of vascular wall permeability and are responsible for the formation of pain.
After sublingual administration of the drug for 3 minutes, up to 70% of the active substance is released, the therapeutic effect is observed approximately 5 minutes after administration.
Dextrose (glucose) monohydrate is an active participant in various metabolic processes in the body.
Pharmacokinetics
Levomenthol solution in menthil isovalerate when administered sublingually is rapidly absorbed from the oral mucosa. The biological transformation of the active substance is carried out in the liver, the agent is excreted in the form of glucuronides by the kidneys.
Dextrose monohydrate in the body is completely absorbed and, as a result, is not eliminated by the kidneys (the presence of this substance in the urine refers to pathological signs).
Indications for use
- neuroses;
- functional cardialgia;
- sea and air sickness - as an antiemetic.
Contraindications
Absolute:
- age up to 3 years;
- hypersensitivity to the constituents of the product.
The drug should be used with extreme caution in the presence of diabetes mellitus.
Validol Avexima, instructions for use: method and dosage
Validol Avexim tablets are taken sublingually.
The tablet must be kept under the tongue until it is completely dissolved. It is recommended to use the product 2-3 times a day, 1 pc. The duration of the course of therapy and the frequency of daily intake are determined taking into account the response to the treatment. In the event of a possible absence of a positive result within 5 minutes after administration or an insufficiently pronounced therapeutic effect, it is imperative to consult a doctor in order to exclude a heart attack, or to prescribe another treatment.
Against the background of intensifying and intense pain, especially with previously diagnosed heart diseases, including exertional angina and myocardial infarction, it is necessary to call emergency help.
Side effects
With prolonged use of Validol Avexim, it is possible to develop lacrimation, mild nausea, and dizziness. These undesirable phenomena usually go away on their own.
Overdose
Symptoms of an overdose may include the following disorders: nausea, headache, agitation, drop in blood pressure, depression of the central nervous system (CNS), impaired heart function. If these reactions occur, you should stop taking the drug and carry out symptomatic therapy.
special instructions
The composition of 1 tablet of Validol Avexim includes dextrose monohydrate (glucose monohydrate) - 188 mg and sugar (sucrose) - 450 mg, which is equivalent to 0.054 bread unit (XE). This fact must be taken into account by patients with diabetes mellitus.
Pediatric use
For children under 3 years of age, drug treatment is contraindicated.
Drug interactions
- nitrates: with simultaneous use with the drug, the headache that develops against the background of therapy with these drugs is relieved;
- neurotropic drugs of a depressing type of action: a combined intake with Validol Avexim aggravates the suppressive effect of these drugs on the central nervous system.
Analogs
An analogue of Validol Avexim is Validol with glucose.
Terms and conditions of storage
Store at a temperature of 12-18 ° C in a place protected from moisture and out of reach of children.
Shelf life is 2 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Validol Avexim
Feedback on Validol Avexim left on specialized sites is mostly positive. Most patients consider it an affordable, inexpensive and effective remedy that quickly relieves symptoms of functional cardialgia, manifestations of neuroses and mood swings. The drug is also successfully used in the development of seasickness / air sickness as an antiemetic agent. It is noted that it improves sleep, helps to cope with headaches, relieves dizziness during motion sickness, and has a refreshing menthol taste. There are no complaints of adverse reactions.
The disadvantages of the remedy are the presence of contraindications and the presence of sugar in the composition. Some are unhappy that the drug cannot be taken with you on the road in the summer, since it must be stored at a temperature no higher than 18 ° C. Since Validol Avexima is not intended for the treatment of coronary heart disease, with severe and increasing pain in the heart area, all patients recommend urgently seeking medical help.
Price for Validol Avexima in pharmacies
The price of Validol Avexima in the form of sublingual tablets can be 35–55 rubles. per package containing 20 pcs.
Validol Avexima: prices in online pharmacies
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Drug name Price Pharmacy |
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Validol Avexima tablets sublingual with glucose 20 pcs. 32 RUB Buy |
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Validol Avexima tablets sublingual. 20 pcs. RUB 54 Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
