Buserelin-long
Buserelin-long: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Buserelin Long
ATX code: L02AE01
Active ingredient: Buserelin (Buserelin)
Manufacturer: JSC "F-Sintez", Russia
Description and photo update: 19.10.2018
Prices in pharmacies: from 3235 rubles.
Buy
Buserelin-Long is an analogue of gonadotropin-releasing hormone (GnRH); antineoplastic agent.
Release form and composition
Dosage form Buserelin-long is a lyophilisate for preparing a suspension for intramuscular (i / m) administration of prolonged action (3.75 mg in vials, 1 vial complete with a solvent in a cardboard box).
Composition of the preparation:
- active substance: buserelin - 3.75 mg;
- auxiliary components: dl-lactic and glycolic acid copolymer - 200 mg, D-mannitol - 85 mg, sodium carmellose - 30 mg, polysorbate-80 - 2 mg.
Solvent: 0.8% mannitol solution in 1 ml of water for injection.
Pharmacological properties
Pharmacodynamics
Buserelin-long is an antineoplastic agent, analogue of gonadotropin-releasing hormone. The mechanism of its action is due to the ability to cause a short-term increase in the level of sex hormones in the blood plasma due to competitive binding with cellular receptors located in the anterior lobe of the pituitary gland.
When using the drug in therapeutic doses for 12-14 days, the gonadotropic pituitary function is blocked.
Buserelin lowers the production of testosterone, follicle-stimulating hormone and luteinizing hormone.
In women, the concentration of estradiol reaches values characteristic of the postmenopausal period. The testosterone content in men decreases to the values observed in the post-castration period.
Pharmacokinetics
Bioavailability after intramuscular injection is high.
T Cmax (time to reach the maximum concentration of a substance in plasma) after the administration of one dose (3.75 mg) - approximately 2-3 hours.
Indications for use
- mammary cancer;
- endometriosis (before and after surgery);
- uterine fibroids;
- hyperplastic processes of the endometrium;
- infertility - within the framework of the IVF program (in vitro fertilization);
- hormone-dependent prostate cancer.
Contraindications
According to the instructions, Buserelin-Long is contraindicated in women during pregnancy and lactation, as well as in all patients in case of hypersensitivity to any component of the drug.
Instructions for use of Buserelin-Long: method and dosage
Buserelin-long is administered intramuscularly.
A suspension for injection is prepared from the lyophilisate just before administration, using the solvent supplied with the kit.
Recommended dosage according to indications:
- hormone-dependent prostate cancer: 1 dose (3.75 mg) 1 time per 4 weeks;
- endometriosis and endometrial hyperplastic processes: 1 dose every 4 weeks, treatment begins in any of the first 5 days of the menstrual cycle, the course of therapy is from 4 to 6 months;
- uterine fibroids: 1 dose 1 time in 4 weeks, treatment begins in any of the first 5 days of the menstrual cycle, before surgery, the drug is used for 3 months, in other cases - 6 months;
- infertility (IVF treatment): 1 dose is administered at the beginning of the follicular or in the middle of the luteal phase (2 or 21-24 days, respectively) of the menstrual cycle preceding the stimulation of ovulation. After reaching a blockade of the pituitary function, which is confirmed by a study of the concentration of estrogen in the blood serum (this indicator should be at least 50% less than the initial level), usually 12-15 days after the administration of Buserelin-Long, provided that there are no ovarian cysts (established using ultrasound) and the thickness of the endometrium is not more than 5 mm, they begin to stimulate superovulation using gonadotropic hormones (under the control of ultrasound and the level of estradiol in the blood serum).
Side effects
Possible reactions in patients of both sexes:
- from the central nervous system: sleep disorders, headache, frequent mood swings, depression;
- on the part of the musculoskeletal system: in the case of long-term treatment - bone demineralization, which can lead to the development of osteoporosis;
- allergic reactions: skin flushing, urticaria; rarely - Quincke's edema;
- others: in some cases - dyspeptic disorders, pulmonary embolism (the relationship of their development with the use of buserelin has not been established).
In women, in addition, the following undesirable phenomena are possible: sweating, pain in the lower abdomen, dryness of the vaginal mucosa, changes in libido; rarely (during the first weeks of treatment) - menstrual bleeding.
In men, in the treatment of prostate cancer in the first 2-3 weeks after the first injection of the drug, in addition, the following side effects are possible: exacerbation and progression of the underlying disease (due to stimulation of the synthesis of gonadotropins and, accordingly, testosterone), increased sweating, hot flashes, gynecomastia, decreased potency, muscle weakness in the lower extremities, renal edema (swelling of the legs, eyelids and face), urinary retention, a transient increase in the concentration of androgens in the blood, a temporary increase in bone pain (eliminated by symptomatic therapy); in some cases - obstruction of the ureters and compression of the spinal cord.
Overdose
Overdose cases of Buserelin-Long have not been reported to date.
special instructions
Before starting treatment, women should exclude pregnancy, cancel hormonal contraceptives if they are used, and replace them with another reliable (non-hormonal) method of contraception.
Ovulation induction should be performed in a hospital setting under the strict supervision of a physician.
At the beginning of the use of the drug, there is a possibility of ovarian cyst formation.
After the cancellation of Buserelin-Long, ovarian function is restored. Menses usually return after 3 months.
For the prevention of side effects, men are recommended to prescribe antiandrogens: within 2 weeks before and 2 weeks after the first administration of buserelin.
Patients with any form of depression during therapy should be under close medical supervision.
During treatment, you should refrain from drinking alcoholic beverages.
Influence on the ability to drive vehicles and complex mechanisms
Given the likelihood of developing undesirable reactions from the central nervous system during therapy, patients should be careful when driving vehicles and performing work that requires attention and increased reaction speed.
Application during pregnancy and lactation
For women during pregnancy and lactation, the use of Buserelin-Long is contraindicated.
Pediatric use
There is no reliable information on the use of the drug in childhood.
Drug interactions
When combined, Buserelin can reduce the severity of the effect of hypoglycemic drugs.
With the simultaneous appointment of funds containing sex hormones (for example, as part of therapy aimed at induction of ovulation), ovarian hyperstimulation syndrome may develop.
Analogs
Buserelin-long analogs are Buserelin and Buserelin-depot.
Analogues on the mechanism of action - Dipherelin, Zoladex, Decapeptil, Lyukrin, Eligard.
Terms and conditions of storage
Shelf life is 2 years.
Storage conditions - dry, protected from light, place inaccessible to children, temperature - up to 25 ° С.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Buserelin Long
Doctors in their reviews of Buserelin-Long speak mostly positively. In their opinion, the remedy is especially effective in the treatment of infertility as part of the IVF program. However, almost all patients report the frequent development of side effects, the most common of which are mood swings, depression, decreased libido, hot flashes and bleeding.
Price for Buserelin-long in pharmacies
The price for Buserelin Long is 3400–4100 rubles. for 1 bottle.
Buserelin Long: prices in online pharmacies
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Drug name Price Pharmacy |
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Buserelin-long 3.75 mg lyophilisate for the preparation of a suspension for intramuscular administration of prolonged action 1 pc. 3235 RUB Buy |
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Buserelin-long FS 3.75 mg lyophilisate for the preparation of a suspension for intramuscular administration of prolonged action 1 pc. 3778 RUB Buy |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
