Beclomethasone
Beclomethasone: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Beclomethasone
ATX code: R01AD01
Active ingredient: beclometasone (beclometasone)
Manufacturer: JSC "Moskhimfarmpreparaty" them. N. A. Semashko ", CJSC" Binnopharm "(Russia), Orion Corporation Orion Pharma (Finland)
Description and photo update: 2019-16-08
Prices in pharmacies: from 199 rubles.
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Beclomethasone is a hormonal drug (glucocorticosteroid) intended for inhalation to affect the mucous membrane of the respiratory organs; one of the means of the basic course of treatment of bronchial asthma.
Release form and composition
The active ingredient is beclomethasone dipropionate.
It is produced in the form of an aerosol for inhalation metered (200 doses in aluminum aerosol cans with a spray system, 1 can in a cardboard box).
The content of the active substance in 1 dose is 50 μg or 250 μg.
Pharmacological properties
Pharmacodynamics
Beclomethasone belongs to glucocorticosteroids and has a weak tropism for GCS receptors. With the participation of enzymes, it turns into an active metabolite - beclomethasone-17-monopropionate (B-17-MP), which is characterized by a pronounced local anti-inflammatory effect. Beclomethasone reduces the intensity of the inflammatory process by suppressing the formation of the chemotaxis substance (effect on late allergic reactions), slows down the development of immediate allergic reactions, which are caused by inhibition of the synthesis of arachidonic acid metabolites and a decrease in the release of inflammatory mediators from mast cells, and also stimulates mucociliary transport processes.
The drug reduces the number of mast cells in the bronchial mucosa, suppresses mucus secretion by the bronchial glands, reduces epithelial edema, bronchial hyperreactivity, marginal accumulation of neutrophils, and also suppresses the production of lymphokines and inflammatory exudate, slows down the migration of macrophages and helps to reduce the intensity of granulation and infiltration processes.
Thanks to beclomethasone, the number of active beta-adrenergic receptors increases, the patient's response to bronchodilators is restored, which reduces the frequency of their use. After inhalation, the substance has practically no resorptive effect.
The drug does not have the ability to stop bronchospasm, and the therapeutic effect develops gradually with maximum severity, usually 5-7 days after the start of therapy.
Pharmacokinetics
More than 25% of beclomethasone, administered by inhalation, is deposited in the respiratory tract, and the remaining amount is deposited in the pharynx and mouth and is swallowed. In the lungs, before absorption, the compound is actively metabolized, forming the active metabolite B-17-MP. Systemic absorption of the latter is carried out in the lungs (up to 36% of the pulmonary fraction of the substance) and the gastrointestinal tract (up to 26% of the amount received here when swallowed). The absolute bioavailability of beclomethasone in unchanged form and B-17-MP is, respectively, approximately 2% and 62% of the dose that entered the body as inhalation.
Beclomethasone is absorbed at a high rate, and the maximum concentration of the substance in the blood plasma is reached in 0.3 hours. B-17-MP is absorbed more slowly. The time to reach the maximum concentration of this metabolite is about 1 hour. An approximate linear relationship was found between the increase in the dose administered by inhalation and the systemic exposure of the active component of the drug.
For beclomethasone, the distribution in tissues is 20 liters, and for B-17-MP - 424 liters. The drug binds well enough (by 87%) to plasma proteins.
Beclomethasone and B-17-MP are characterized by high plasma clearance of 150 l / h and 120 l / h, respectively. The half-life is 0.5 hours and 2.7 hours, respectively.
Indications for use
The action of the drug is aimed at reducing epithelial edema, mucus secretion by the bronchial glands, marginal accumulation of neutrophils, bronchial hyperreactivity, inflammatory exudate (fluid at the site of inflammation).
According to the instructions, Beclomethasone is prescribed in the following cases:
- Bronchial asthma (inhalation);
- Prevention and treatment of allergic rhinitis, including vasomotor rhinitis and hay fever rhinitis (intranasal use);
- Infectious and inflammatory diseases of the ear and skin (external and local) - in combination with antimicrobial agents.
Contraindications
- Non-asthmatic bronchitis, acute bronchospasm;
- Frequent nosebleeds, hemorrhagic diathesis;
- Systemic infections, including pulmonary tuberculosis, acute respiratory infections, herpetic eye damage.
Aerosol Beclomethasone is contraindicated in children under 6 years of age and women in the first trimester of pregnancy.
Instructions for the use of Beclomethasone: method and dosage
Inhalation use:
- Adults - 500 mcg 2 times a day or 250 mcg 4 times a day, the daily dose should not exceed 1000 mcg (2000 mcg is allowed only in very severe cases, while the daily dose is divided into 4 doses);
- Children from 6 years old - 50-100 mcg 2 to 4 times a day.
Intranasal administration:
- Adults and children over 12 years old - 100 mcg 3-4 times a day in each nasal passage, not exceeding a daily dose of 1000 mcg;
- Children 6-12 years old - 50 mcg in each nasal passage (no more than 500 mcg per day) with the same frequency of doses as adults.
A more accurate dosage regimen and duration of treatment is determined by the doctor.
Side effects
Beclomethasone aerosol can cause unwanted body reactions, in particular, such as:
- Sneezing, cough, throat irritation, dysphonia, rarely - paradoxical bronchospasm (eliminated by inhalation bronchodilators), eosinophilic pneumonia;
- Candidomycosis of the upper respiratory tract and oral cavity;
- Dizziness, headaches, increased intraocular pressure, cataracts, lymphopenia, eosinopenia, leukocytosis - with prolonged use in large doses;
- Epistaxis, rhinitis, perforation of the nasal septum, atrophy of the mucous membrane - with intranasal administration;
- Dysfunction of the hypothalamic-pituitary-adrenal system - with a single use of more than 1000 mcg of beclomethasone dipropionate;
- Allergic reactions.
Overdose
Symptoms of an acute overdose may develop with a single inhalation of a high dose of more than 1 g. In this case, signs of suppression of the function of the adrenal cortex are most often manifested, and there is no need for emergency therapy. This is due to the restoration of this function over several days, which is confirmed by a change in the level of cortisol in the blood plasma.
In chronic overdose (long-term treatment with the drug in doses of more than 1.5 g), persistent suppression of the adrenal cortex function can be observed. In such a situation, the reserve function of the adrenal cortex should be regularly monitored. In case of an overdose, the course of treatment with Beclomethasone can be continued, provided that doses are administered sufficient to maintain the therapeutic effect.
special instructions
For women in the II and III trimesters of pregnancy, as well as for nursing mothers, the advisability of using Beclomethasone is determined by the doctor. If the drug is taken during lactation, breastfeeding should be discontinued.
Caution is required for intranasal use of the spray by persons with pronounced nasal septum, glaucoma, amebiasis, hypothyroidism, severe renal failure.
Recently suffered myocardial infarction, nasal surgery performed in the recent past, and nasal injuries are the reason for limiting the use of Beclomethasone.
Influence on the ability to drive vehicles and complex mechanisms
Inhalation of Beclomethasone does not significantly affect the ability to drive vehicles or engage in potentially hazardous activities that require an increased speed of reactions and serious concentration.
Application during pregnancy and lactation
The drug during pregnancy and during breastfeeding is used with extreme caution, only if the expected benefit to the mother exceeds the possible risks to the fetus and baby.
Newborns whose mothers were treated with Beclomethasone during pregnancy should be carefully examined for adrenal insufficiency.
Pediatric use
Children under 6 years old are not assigned.
The drug, which contains 250 mcg of beclomethasone in 1 dose, is not intended for children under 18 years of age. When administered by inhalation, a single dose for children is 50–100 mcg, and the frequency of use does not exceed 2–4 times a day.
Drug interactions
Beclomethasone restores the patient's response to beta-adrenergic agonists, which significantly reduces the frequency of their use.
When the drug is combined with rifampicin, phenytoin, phenobarbital and other inducers of microsomal liver enzymes, the therapeutic effect of beclomethasone becomes weaker.
The simultaneous use of Beclomethasone with theophylline, methandienone, beta 2 -adrenomimetics, estrogens, as well as systemic glucocorticosteroids increases the effectiveness of beclomethasone.
With the joint administration of Beclomethasone and beta-adrenergic agonists, the effect of the latter on the body is enhanced.
In especially sensitive patients, the interaction of beclomethasone with metronidazole and disulfiram is possible due to the content of ethyl alcohol in the preparation.
Analogs
Direct analogues of Beclomethasone, which have beclomethasone dipropionate as the active active ingredient: Beklazon Eco, Beklat, Beklospir, Bekotid, Klenil, Beklazon Eco Light Breathing, Beclomethasone-aeronautical.
Drugs of a similar action belonging to the same pharmaceutical subgroup: Asmanex Twistheiler, Benacort, Budecort, Budenite Steri-Neb, Budesonide, Budesonide Easyheiler, Budiair, Pulmicort, Tafen Novolizer, Flixotide, Alvesco, Novopulmon Eonolizer-Native.
Terms and conditions of storage
Store at a temperature not exceeding 30 ° C.
Shelf life - 3 years, after opening the spray, the contents should be used within 6 months.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews of Beclomethasone
According to reviews, Beclomethasone in most cases helps to quickly relieve the patient's condition. There are reports of unpleasant side effects, but in general, doctors and patients consider it an effective drug.
Price for Beclomethasone in pharmacies
On average, the price of Beclomethasone, which contains 50 mcg in 1 dose, is 131–188 rubles. The cost of an aerosol for inhalation, in 1 dose of which contains 250 mcg, varies from 385 to 410 rubles.
Beclomethasone: prices in online pharmacies
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Drug name Price Pharmacy |
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Beclomethasone 100 μg / dose 200 doses aerosol for inhalation metered dose 1 pc. 199 RUB Buy |
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Beclomethasone asp. d / ing dosir. 100 mcg / dose 200 doses bottle with dosage nozzle 352 r Buy |
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Beclomethasone 250 mcg / dose 200 doses aerosol for inhalation metered dose 1 pc. 383 r Buy |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
