Batrafen

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Batrafen: instructions for use and reviews

1. Release form and composition
2. Pharmacological properties
3. Indications for use
4. Contraindications
5. Method of application and dosage
6. Side effects
7. Overdose
8. Special instructions
9. Application during pregnancy and lactation
10. Use in childhood
11. Drug interactions
12. Analogs
13. Terms and conditions of storage
14. Terms of dispensing from pharmacies
15. Reviews
16. Price in pharmacies

Latin name: Batrafen

ATX code: D01AE14

Active ingredient: ciclopirox (ciclopirox)

Producer: Aventis Pharma (India), Sanofi-Aventis Deutschland GmbH (Germany), Aventis Pharma International (France)

Description and photo update: 2019-19-08

Prices in pharmacies: from 2250 rubles.

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Batrafen is a broad-spectrum antifungal drug.

Release form and composition

Dosage forms of the drug:

cream for external use 1%: white or almost white (15 g each in aluminum tubes, 1 tube each in a cardboard box);
gel for external use (20 or 50 mg in aluminum tubes, 1 tube in a cardboard box);
solution for external use (20 ml in vials);
vaginal cream (40 g in a tube, complete with 6 disposable tips);
nail polish 8% (3 g each in a bottle with a brush cap, in a cardboard box 1 bottle).

The main active ingredient is ciclopirox.

Pharmacological properties

Pharmacodynamics

The active component of Batrafen, ciclopirox, has an antifungal effect. The mechanism of antifungal action is based on inhibiting the entry into the cell and inducing the elimination from the cell of components that are necessary for its vital activity.

When applied topically, the drug has a wide spectrum of action and is effective against yeast-like fungi (including fungi of the genus Candida), dermatomycetes, molds and other types of fungi. Batrafen also has activity against some strains of gram-negative / gram-positive bacteria.

The activity of the drug is noted against Candida (including C. pseudotropicalis, C. lipolytica, C. brumpti, C. guilliermondii, C. albicans, C. tropicalis, C. utilis, C. krusei, C. parapsilosis, C. viswanathii), Trichophyton (including T. equinum, T. rubrum, T. ferrugineum, T. epilans, T. schoenleinii, T. gallinae, T. mentagrophytes, T. verrucosum, T. tonsurans, T. terrestre, T. quinckeanum, T. concentricum, T. soudanense, T. violaceum), Microsporum (including M. gypseum, M. langeronii, M. canis, M. audouinii, M. nanum), Madurella (including M. grisea, M. mycetomatis), Cladosporium (including C. carrionii, C. trichoides), Phialophora (including P. jeanselmei, P. pedrosoi, P. gougerotti), Aspergillus (including A. fumigatus, A. flavus, A. niger), Penicillium (including P. chrysogenum, P. notatum), Paecilomyces variotii, Allescheria boydii,Leptosphaeria senegalensis, Pyrenochaeta romeroi, Hormodendrum dermatitidis, Epidermophyton floccosum, Sporotrichum schenckii, Cryptococcus neoformans, Histoplasma capsulatum, Torulopsis glabrata, Torula bergeri, Mucor miehei, Absidia corymbifera, Fusarium solani, Blastomyces dermatitidis, Paracoccidioides brasiliensis, Saccharomyces cerevisiae.

Pharmacokinetics

When applied topically, ciclopirox quickly penetrates the mucous membranes, skin and its appendages. Its concentration in these tissues 1.5-6 hours after application significantly exceeds the minimum inhibitory concentration against pathogenic fungi.

When applying a cream for external use on large areas (750 cm ²) and for a long time (6 hours and longer), the substance can be detected in the blood (1.3% of the dose), binding to plasma proteins - 94-97%, T _{1 / 2} (half-life) is 1.7 hours. The main route of excretion is the kidneys.

With a one-day application of Batrafen varnish, the values of fungicidal concentrations are 20-30 times higher than the plasma C _max (maximum concentration of the substance) (plasma C _max for dermatophytes, fungi of the genus Candida, yeast-like and mold fungi is 0.98-3.9 μg / ml; Trichomonas vaginalis and mycoplasma - from 7.8 to 31.3 μg / ml).

Indications for use

According to the instructions, Batrafen is used to prevent and treat fungal infections of the mucous membranes, skin and nails.

Cyclopirox is active against moldy, yeast-like and other types of fungi, dermatomycetes and some types of gram-positive and gram-negative bacteria.

Contraindications

The use of Batrafen is contraindicated in children under 10 years of age, pregnant and lactating women, as well as in patients with hypersensitivity to the active ingredient of the drug.

Instructions for the use of Batrafen: method and dosage

Batrafen in the form of a cream for external use is rubbed into the areas of the skin affected by the fungus 2 times a day. Treatment lasts about two weeks until the complete disappearance of the skin manifestations of the disease and another week to prevent the development of relapses.

Vaginal cream and topical solution are used to treat vulvovaginitis and vaginitis. Douching is done with a solution of Batrafen once a day for 5 days. Vaginal cream in the amount of 5 g once a day (at night) is inserted deep into the vagina and treated with it around the vaginal opening, including the anus. The treatment is carried out for 6-14 days.

In case of onychomycosis, treatment with the drug lasts 4–28 weeks, while it is advisable to regularly remove all damaged areas of the nail and apply the agent overnight under a bandage. Usually, the cream is kept under the bandage all night, in the morning it is removed and the Batrafen solution is rubbed in several times throughout the day.

Varnish Batrafen is applied in the first month of treatment - once a day every other day, in the second month - 2 times a week, during the third month - once a week. Once a week, the varnish is removed and, after steaming in warm water, the top layer of the affected nail plate is ground off.

Side effects

The use of Batrafen can cause itching, skin irritation, redness and flaking.

Overdose

There is no information.

special instructions

With fungal diseases of the vagina, the course of treatment should be taken simultaneously by both sexual partners.

With onychomycosis, you should not use cosmetic nail polish.

Avoid getting the drug in the eyes.

Application during pregnancy and lactation

Batrafen is not prescribed during pregnancy / lactation.

Pediatric use

Therapy with Batrafen is contraindicated in patients under 10 years of age.

Drug interactions

Systemic antimycotics enhance the effect of the cream for external use Batrafen.

Analogs

An analogue of Batrafen is the drug Fongial.

Terms and conditions of storage

Store at a temperature not exceeding 25 ° C.

The drug is suitable for use for 3 years.

Terms of dispensing from pharmacies

Available without a prescription.

Reviews about Batrafen

The largest number of reviews about Batrafen is in the form of nail polish. The drug is evaluated in different ways. In some cases, its high efficiency is noted, while a long course is required for complete recovery. However, many users point out that the cost of the varnish is unreasonably high, since it does not have the claimed therapeutic effect.

Price for Batrafen in pharmacies

The approximate price for Batrafen is: 8% nail polish (1 bottle of 3 g) - 2107-2244 rubles, 1% cream for external use (1 tube of 15 g) - 311-443 rubles.

Batrafen: prices in online pharmacies

Drug name

Price

Pharmacy

Batrafen (varnish) 8% nail polish 3 g 1 pc.

2250 RUB

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Anna Kozlova Medical journalist About the author

Education: Rostov State Medical University, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!