Hydrocortisone - Instructions, Use, Contraindications

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Hydrocortisone

Instructions for use:

1. 1. Dosage form
2. 2. Active ingredient
3. 3. Pharmacological action
4. 4. Indications for use
5. 5. Contraindications to use
6. 6. Side effects
7. 7. Instructions for use
8. 8. Storage conditions

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from 20 rubles.

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Hydrocortisone is a steroid hormonal drug that is produced by the adrenal cortex and takes part in carbohydrate and protein metabolism.

Pharmacological group - glucocorticosteroids.

Dosage form

The drug is available in the following forms:

• hydrocortisone eye ointment;
• eye drops Hydrocortisone;
• Hydrocortisone suspension for intramuscular and intraarticular injection;
• powder for preparation of injections;
• Hydrocortisone tablets;
• Hydrocortisone ointment;

Active substance

Hydrocortisone

pharmachologic effect

The drug Hydrocortisone is a synthetic glucocorticosteroid agent for systemic and local use, with a pronounced fast-acting anti-inflammatory, anti-exudative (decongestant), desensitizing (antiallergic) immunosuppressive, anti-shock and antitoxic effect.

Hydrocortisone inhibits the release of inflammatory mediators through a certain chain of reactions. The immunosuppressive effect of the drug is due to the inhibition of the reactions of the immune system.

Indications for the use of Hydrocortisone

For external use of Hydrocortisone, Hydrocortisone ointment is used for uninfected surface skin surfaces.

For topical use, eye drops and hydrocortisone eye ointment are used for inflammatory processes in the anterior chamber of the eye without damaging the cornea:

• uveitis;
• keratitis;
• iridocyclitis;
• blepharitis;
• allergic conjunctivitis, etc.

Periarticular or intra-articular (hydrocortisone acetate in suspension):

• post-traumatic osteoarthritis;
• carpal tunnel syndrome;
• nonspecific tendosynovitis;
• rheumatoid arthritis;
• epicondylitis;
• subacute and acute bursitis;
• reactive synovitis.

Intradermal injection (hydrocortisone acetate in suspension):

• toxidermia;
• lupus erythematosus;
• atopic dermatitis (neurodermatitis);
• annular granuloma;
• lichen planus, etc.

Systemic therapy (inside, i / m, i / v) Hydrocortisone suspension, tablets, powder for preparation of injections:

• endocrine disorders - hypercalcemia, as a result of the tumor process,
• non-purulent thyroiditis (thyrotoxic crisis), adrenal hyperplasia (congenital), adrenal insufficiency;
• acute conditions of allergic reactions;
• emergency conditions;
• collagenoses;
• skin diseases;
• respiratory diseases, such as respiratory pneumonitis (c-M. Mendelssohn), etc.
• hematological diseases: hypoplastic anemia (congenital), erythroblastopenia, secondary thrombocytopenia, autoimmune anemia;
• gastrointestinal diseases: b. Crohn (in complex therapy);
• tuberculous meningitis (in combination with anti-tuberculosis chemotherapy);
• trichinosis with damage to the myocardium or nervous system;
• multiple sclerosis;
• poisoning with chlorine, organophosphorus substances, vitamin D, quinine, acids, with bites of snakes, spiders and insects.

Contraindications to the use of Hydrocortisone

For external and local administration of Hydrocortisone:

• children under 2 years old,
• individual hypersensitivity to the drug;
• short period after vaccination;
• in case of violations of the integrity of the skin cover (ulcers, cracks, wounds) and eye epithelium;
• viral, fungal and bacterial diseases of the eyes and skin;
• dermatitis near the mouth;
• acne vulgaris acne vulgaris;
• localization on the face of Rosacea;

To admit with caution in cases of: pregnancy (I trimester) and lactation, systemic lesions in tuberculosis, diabetes mellitus.

With systemic therapy with hydrocortisone, caution is required when:

• severe forms of arterial hypertension;
• Itsenko-Cushing's syndrome;
• peptic ulcers;
• diverticulitis;
• osteoporosis;
• postoperative period;
• fungal diseases;
• lactation and pregnancy;
• acute endocarditis;
• nephritis;
• renal failure;
• tendency to thromboembolism;
• herpes fever;
• previous arthroplasty;
• AIDS, HIV infection;
• myasthenia gravis;
• individual hypersensitivity to the drug.

Side effects

According to the instructions for Hydrocortisone, when using Hydrocortisone, some undesirable side effects may occur.

When applied topically, allergies, burning, injection of blood vessels of the sclera may develop; In the case of prolonged use of Hydrokorizon drops or Hydrokorizon eye ointment, subcapsular cataract, glaucoma or exophthalmos may develop;

When applied externally, allergic skin reactions may occur.

Local and general systemic side effects occur in the case of prolonged use of Hydrocortisone on very large surfaces or in areas of damaged skin, as well as when using Hydrocortisone ointment under occlusive dressings.

When using hydrocortisone for systemic therapy, the following side effects are possible:

From the endocrine system:

• decreased carbohydrate tolerance;
• hyperglycemia up to diabetes mellitus;
• the need to increase the dose of insulin or other hypoglycemic agents in diabetics;
• growth retardation in children;
• Itsenko-Cushing's syndrome;
• pituitary-adrenal insufficiency;
• dysmenorrhea;
• hirsutism;
• hormonal obesity;
• atrophy of the adrenal cortex - in case of prolonged use of Hydrocortisone

From the side of the musculoskeletal system:

• osteoporosis with pathological fractures, compression fractures of the vertebrae;
• aseptic necrosis of the heads of the humerus and femur;
• arthropathy;
• arthralgia;
• steroid myopathy;

From the digestive tract:

• bowel perforation;
• gastric bleeding;
• peptic ulcers;
• pancreatitis;
• dyspepsia;
• esophagitis.

From the skin and mucous membranes:

• impairment of wound healing,
• allergic reactions
• discoloration of the skin

From the side of the central nervous system and organs of vision:

• mental disorders;
• subcapsular cataract;
• glaucoma;
• increased intracranial pressure.

Other side effects: immunosuppressive conditions, impaired water and electrolyte metabolism, increased blood pressure, vasculitis.

Instructions for the use of Hydrocortisone

For emergencies, intravenous hydrocortisone is recommended.

The dose for adults starts from 100 ml to 450-500 ml and more, depending on the severity of the patient's condition. Prescribe up to 1500 mg / day.

IM for adults - 125-200 mg per day

Children - 15-30 mg per day, dividing the dose into several doses.

Intra-articular and periarticular, hydrocortisone is administered in suspension:

• adults 3-50 mg;
• children 25 mg - from 3 months. up to 1 year; 25-50 mg - from 1 to 6 years; 50-75 mg - from 6 to 14 years old.

Eye ointment Hydrocortisone is injected into the conjunctival sac 1, 2 or 3 times a day.

Ointment Hydrocortisone is applied in a thin layer to the skin no more than four times a day, the course of treatment is no more than three weeks.

According to the instructions for Hydrocortisone, the initial oral dose is 20-240 ml, followed by a decrease. But, with an exacerbation of multiple sclerosis, the dose can be increased to 800 mg per day, with a subsequent decrease.

Storage conditions

Store at room temperature.

Hydrocortisone: prices in online pharmacies

Drug name Price Pharmacy

Hydrocortisone (eye ointment) 0.5% eye ointment 5 g 1 pc. RUB 20 Buy

Hydrocortisone 1% ointment for external use 10 g 1 pc. RUB 24 Buy

Hydrocortisone (eye ointment) 0.5% eye ointment 3 g 1 pc. RUB 25 Buy

Hydrocortisone 1% ointment for external use 10 g 1 pc. RUB 26 Buy

Hydrocortisone 1% ointment 10 g 1 pc. RUB 27 Buy

Hydrocortisone ointment for external use. approx. 1% tube 10g 28 RUB Buy

Hydrocortisone (ophthalmic ointment) 5 mg / g ophthalmic ointment 3 g 1 pc. RUB 29 Buy

Reviews Hydrocortisone (eye ointment) RUB 29 Buy

Hydrocortisone eye ointment 0.5% 3g RUB 30 Buy

Hydrocortisone ointment 1% 10g RUB 30 Buy

Hydrocortisone (eye ointment) 0.5% eye ointment 5 g 1 pc. RUB 33 Buy

Hydrocortisone eye ointment 0.5% 5g RUB 45 Buy

Hydrocortisone eye ointment 0.5% tube 5g RUB 47 Buy

Hydrocortisone 1% ointment for external use 15 g 1 pc. RUB 47 Buy

Hydrocortisone eye ointment. 0.5% 3g 111 RUB Buy

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Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!