Vixipin
Vixipin: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Viksipin
ATX code: S01XA
Active ingredient: methylethylpyridinol (Methylethylpiridinol)
Manufacturer: Solopharm (Grotex, LLC) (Russia)
Description and photo update: 28.11.2018
Prices in pharmacies: from 137 rubles.
Buy
Vixipin is an ophthalmic drug with antiaggregatory and antihypoxic action.
Release form and composition
Vixipin is released in the form of eye drops: a transparent or almost transparent, colorless or slightly colored solution.
Three forms of release of the drug allow you to choose the most convenient option for use for each patient:
- Uni: innovative unidose packaging (sterile polyethylene packaging of one dose of the drug that does not contain preservatives): in a cardboard box 2, 4 or 6 bags of filtered film containing a dropper tube made of polypropylene or low density polyethylene, 0.5 ml each;
- delta: multi-dose in a vial made of polyethylene terephthalate with a dropper; 1 bottle of 10 ml in a foil bag;
- ultra: multi-dose in a glass bottle equipped with a special flight finger rest; in a cardboard box 1 glass bottle with / without a 5 ml finger-rest.
Each pack also contains instructions for the use of Vixipin.
Composition of 1 ml drops:
- active substance: methylethylpyridinol hydrochloride - 10 mg;
- auxiliary components: sodium hyaluronate - 1.8 mg; hydroxypropyl beta cyclodextrin (HPBCD) 20 mg; potassium dihydrogen phosphate - 10.8 mg; sodium benzoate - 2 mg; disodium edetate dihydrate (Trilon B) - 0.2 mg; sodium hydrogen phosphate dihydrate - 0.36 mg; phosphoric acid solution 2M - up to pH 4–5; water for injection - up to 1 ml.
Pharmacological properties
Pharmacodynamics
Methylethylpyridinol - the active substance of Vixipin, is an angioprotector, provides the following effects of the drug:
- decreased capillary permeability;
- strengthening of the vascular wall;
- stabilization of the cell membrane;
- inhibition of platelet aggregation;
- decrease in blood clotting and viscosity;
- antiaggregatory and antihypoxic action.
The action of some auxiliary components:
- hyaluronic acid (sodium hyaluronate): moisturizes the cornea, eliminates discomfort, improves drug tolerance;
- cyclodextrin: increases bioavailability; reduces local irritation; potentiates the action of active ingredients.
Pharmacokinetics
Methylethylpyridinol penetrates into the eye tissue quickly, where it is deposited and metabolized. The concentration in the tissues of the eye is higher than in the blood plasma.
Five metabolites have been identified, which are represented by conjugated and dealkylated products of its biotransformation.
Metabolism occurs in the liver, excretion of metabolites is carried out by the kidneys. The average level of binding to blood plasma proteins is 42%.
Indications for use
- inflammation and burns of the cornea (therapy and prevention);
- hemorrhage in the anterior chamber of the eye (therapy);
- hemorrhages in the sclera in elderly patients (therapy and prevention);
- complications of myopia (therapy);
- diabetic retinopathy;
- thrombosis of the central retinal vein and its branches.
Contraindications
- age up to 18 years;
- pregnancy and the period of breastfeeding;
- individual intolerance to the components of the drug.
Vixipin, instructions for use: method and dosage
Vixipin eye drops are intended for instillation into the conjunctival cavity.
Dosage regimen: 2-3 times a day, 1-2 drops.
The duration of use usually ranges from 3 to 30 days and is determined individually, depending on the course of the disease. With good tolerance and indications, the duration of the course can be increased to 6 months, or therapy can be repeated 2-3 times a year.
Side effects
Depending on tolerance, patients during the use of Vixipin may experience such disorders as local allergic reactions, itching, burning sensation, short-term conjunctival hyperemia.
Overdose
There is no information.
special instructions
The advantages of each form of release:
- Unidoses (0.5 ml each): convenient to use at work and on a trip; a fixed dose in a separate package; after opening, the unidose bottle is closed;
- delta, multi-dose (10 ml each): simple and easy to use bottle; does not require effort when pressed; additional protection of the bottle with a foil sachet - super-foil; affordable price;
- ultra, dosing drops (5 ml each): prevents contamination of the contents of the bottle; comfortable instillation due to the convenient location of the fingers facilitates dosing of the drug.
Patients for whom combination therapy with other eye drops is indicated should instill Vixipin in the last place, observing a break of at least 15 minutes.
Application during pregnancy and lactation
Vixipin eye drops are not prescribed during pregnancy / lactation.
Pediatric use
Therapy with the drug in patients under 18 years of age is contraindicated.
Drug interactions
Do not mix Vixipin with other medicinal solutions.
Analogs
Viksipin analogs are Cardioxipin, Methylethylpyridinol, Emoxipin, Emoxibel, etc.
Terms and conditions of storage
Store at temperatures up to 25 ° C. Keep out of the reach of children.
Shelf life is 2 years.
You can use Vixipin after opening the bottle for 30 days.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Vixipin
Reviews about Vixipin are few. Users often report a burning sensation after instilling the solution. It is also noted that it is difficult to open the ultra bottle, equipped with a special device for fingers.
Price for Vixipin in pharmacies
The approximate price for Vixipin is: 10 dropper tubes of 0.5 ml - 205-213 rubles, 1 bottle of 5 ml - 204-280 rubles, 1 bottle of 10 ml - 198-210 rubles.
Vixipin: prices in online pharmacies
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Drug name Price Pharmacy |
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Vixipin 1% eye drops 0.5 ml 10 pcs. RUB 137 Buy |
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Vixipin 1% eye drops 10 ml 1 pc. 210 RUB Buy |
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Vixipin cap. eye 1% fl. 10 ml 231 RUB Buy |
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Vixipin 1% eye drops 5 ml 1 pc. 243 r Buy |
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Vixipin eye drops 1% fl. 5 ml 308 RUB Buy |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
