ACTS 200 - Instructions For The Use Of Effervescent Tablets, Price, Reviews

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ACTS 200 - Instructions For The Use Of Effervescent Tablets, Price, Reviews
ACTS 200 - Instructions For The Use Of Effervescent Tablets, Price, Reviews

Video: ACTS 200 - Instructions For The Use Of Effervescent Tablets, Price, Reviews

Video: ACTS 200 - Instructions For The Use Of Effervescent Tablets, Price, Reviews
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ACC 200

ACTS 200: instructions for use and reviews

  1. 1. Release form and composition
  2. 2. Pharmacological properties
  3. 3. Indications for use
  4. 4. Contraindications
  5. 5. Method of application and dosage
  6. 6. Side effects
  7. 7. Overdose
  8. 8. Special instructions
  9. 9. Application during pregnancy and lactation
  10. 10. Use in childhood
  11. 11. In case of impaired renal function
  12. 12. In case of impaired liver function
  13. 13. Drug interactions
  14. 14. Analogs
  15. 15. Terms and conditions of storage
  16. 16. Terms of dispensing from pharmacies
  17. 17. Reviews
  18. 18. Price in pharmacies

Latin name: ACC 200

ATX code: R05CB01

Active ingredient: acetylcysteine (acetylcysteine)

Manufacturer: Hermes Pharma (Austria), Hermes Arzneimittel (Germany), Salutas Pharma GmbH (Germany)

Description and photo updated: 22.11.2018

Prices in pharmacies: from 100 rubles.

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Effervescent tablets ACTS 200
Effervescent tablets ACTS 200

ACTS 200 is a mucolytic drug.

Release form and composition

Dosage form ACC 200 - effervescent tablets: flat-cylindrical, white, with a risk on one side, with a blackberry smell (a slight sulfur smell is allowed), the resulting solution is colorless, transparent (20 or 25 tablets in a tube, in a cardboard box 1 tube containing 20 tablets, or 2 or 4 tubes of 25 tablets; 4 tablets in a strip, in a cardboard box 15 strips).

Composition of 1 effervescent tablet:

  • active substance: acetylcysteine - 200 mg;
  • auxiliary components: anhydrous citric acid, sodium bicarbonate, anhydrous sodium carbonate, mannitol, anhydrous lactose, ascorbic acid, sodium saccharinate, sodium citrate, blackberry flavor "B".

Pharmacological properties

Pharmacodynamics

Acetylcysteine is a derivative of the amino acid cysteine and has a mucolytic effect. The substance directly affects the rheological properties of sputum, thereby facilitating its discharge. Reducing the viscosity of sputum occurs due to the ability of acetylcysteine to break disulfide bonds of mucopolysaccharide chains and cause depolymerization of mucoproteins in sputum. The activity of the drug is preserved in the presence of purulent sputum. Its reactive sulfhydryl groups bind with oxidative radicals and neutralize them, providing an antioxidant effect. Acetylcysteine promotes the synthesis of glutione, which plays an important role in the antioxidant system and chemical detoxification of the body. The drug increases the protection of cells from the damaging effects of free radical oxidation, which usually accompanies intense inflammatory reactions.

In patients with chronic bronchitis and cystic fibrosis, prophylactic use of acetylcysteine reduces the frequency and severity of exacerbations of bacterial etiology.

Pharmacokinetics

Acetylcysteine is highly absorbed. In a short time, it is metabolized in the liver, where the pharmacologically active metabolite cysteine is formed, as well as diacetylcysteine, cystine and mixed disulfites.

Bioavailability is 10%, which is due to the effect of the first passage through the liver. The maximum plasma concentration is reached in 1-3 hours. Communication with plasma proteins - 50%.

Excretion is carried out by the kidneys in the form of inactive metabolites. The half-life is about 1 hour, in patients with impaired liver function - up to 8 hours. Acetylcysteine crosses the placental barrier. There is no data on its ability to penetrate the blood-brain barrier, as well as to be excreted in the milk of lactating women.

Indications for use

According to the instructions, ACC 200 is indicated for diseases accompanied by the formation of viscous sputum:

  • bronchitis (acute, chronic, obstructive);
  • tracheitis;
  • laryngotracheitis;
  • lung abscess;
  • pneumonia;
  • bronchiectasis;
  • bronchial asthma;
  • chronic obstructive pulmonary disease;
  • bronchiolitis;
  • cystic fibrosis;
  • sinusitis (acute and chronic);
  • otitis media (otitis media).

Contraindications

Absolute contraindications:

  • exacerbation of gastric ulcer and duodenal ulcer;
  • pulmonary hemorrhage, hemoptysis;
  • lactase deficiency, lactose intolerance, glucose-galactose malabsorption;
  • age up to 2 years;
  • pregnancy, breastfeeding period;
  • increased sensitivity to the components of ACC 200.

Relative contraindications:

  • history of peptic ulcer and duodenal ulcer;
  • bronchial asthma;
  • obstructive bronchitis;
  • renal or hepatic impairment;
  • histamine intolerance (long-term use of acetylcysteine can lead to symptoms of intolerance, such as headache, itching, vasomotor rhinitis);
  • varicose veins of the esophagus;
  • arterial hypertension;
  • diseases of the adrenal glands.

Instructions for use of ACTS 200: method and dosage

The drug is taken orally after meals.

An effervescent tablet ACTS 200 is dissolved in 1 glass of water, taken immediately after dissolution. The finished solution can be left for 2 hours. Taking additional liquid increases the effect of the drug.

Duration of use for short-term colds - 5-7 days. Longer use, aimed at achieving a preventive effect, is allowed for chronic bronchitis and cystic fibrosis.

Recommended dosage for mucolytic therapy:

  • children 2-6 years old: 0.5 pcs. 2-3 times a day;
  • children 6-14 years old: 1 pc. 2 times a day;
  • children over 14 years old and adults: 1 pc. 2-3 times a day.

Recommended dosage for cystic fibrosis:

  • children 2-6 years old: 0.5 pcs. 4 times a day;
  • children over 6 years old: 1 pc. 3 times a day.

ACTS 200 is recommended to be taken no later than 18:00.

Side effects

  • respiratory system: shortness of breath, bronchospasm (mainly observed in patients with bronchial hyperreactivity in bronchial asthma);
  • senses: tinnitus;
  • gastrointestinal tract: abdominal pain, stomatitis, nausea, vomiting, diarrhea, dyspepsia;
  • cardiovascular system: tachycardia, decreased blood pressure;
  • allergic reactions: rash, itching, exanthema, urticaria, angioedema, anaphylactic reactions up to anaphylactic shock, Stevens-Johnson syndrome, Lyell's syndrome;
  • other: fever, headache, decreased platelet aggregation.

There have been reports of hypersensitivity reactions accompanied by bleeding.

Overdose

Overdose symptoms of ACC 200: diarrhea, heartburn, nausea, vomiting, stomach pain.

Symptomatic treatment is recommended.

special instructions

Patients with diabetes mellitus should take into account that one ACC 200 tablet corresponds to 0.006 XE.

When preparing the solution, use only glassware. It is recommended to avoid contact of the drug with metals, rubber, easily oxidized substances and oxygen.

If changes in the skin and mucous membranes develop while taking the drug, it is required to immediately stop therapy and consult a doctor due to the risk of developing such severe allergic reactions as Stevens-Johnson syndrome and Lyell's syndrome.

When prescribing the drug to patients with obstructive bronchitis and bronchial asthma, bronchial patency should be monitored.

Keep the tube tightly closed.

Influence on the ability to drive vehicles and complex mechanisms

There is no data on the effect of ACC 200 on the ability to drive vehicles and other complex mechanisms that require the speed of psychomotor reactions.

Application during pregnancy and lactation

Due to the lack of data on the safety and efficacy of the drug in pregnant women, the use of the drug is possible only when the expected benefit to the mother outweighs the possible risk to the fetus.

If it is necessary to use ACTS 200 during lactation, breastfeeding should be discontinued.

Pediatric use

ACTS 200 is contraindicated in children under 2 years of age.

With impaired renal function

Effervescent tablets ACTS 200 are used with caution in patients with renal failure.

If liver function is impaired

In case of liver failure, the drug should be taken with caution.

Drug interactions

  • antitussives: risk of sputum stagnation;
  • oral antibiotics (penicillins, tetracyclines, cephalosporins, etc.): the risk of a decrease in the antibacterial activity of antibiotics. The interval between taking these drugs should be at least 2 hours (except for cefixime and loracarbef);
  • nitroglycerin and vasodilators: may increase the vasodilator effect.

Analogs

Analogs of ACC 200 are ACC Long, Fluimucil, Acetylcysteine, Mukomist, Acestin, Mukonex, N-AC-ratiopharm, ESPA-NAC, etc.

Terms and conditions of storage

Store in a dry place at a temperature not exceeding 25 ° C. Keep out of the reach of children.

Shelf life is 3 years.

Terms of dispensing from pharmacies

Available without a prescription.

Reviews about ACC 200

Reviews of the ACC 200 online are mostly positive. Patients note the effectiveness of the drug in relieving sputum discharge after just a few doses. Also in the reviews, attention is drawn to the convenient form of release of ACC 200. Among the minuses, the presence of contraindications and the risk of side effects are indicated.

Price for ACC 200 in pharmacies

Estimated price for ACC 200, 200 mg effervescent tablets, 20 pcs. is 300 rubles.

ACC 200: prices in online pharmacies

Drug name

Price

Pharmacy

ACC 200 mg granules for oral solution with orange flavor or aroma 3 g 20 pcs.

RUB 100

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ACC 200 mg granules for preparation of oral solution 3 g 20 pcs.

RUB 128

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ACC 200 200 mg effervescent tablets 20 pcs.

241 RUB

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Azz 200 tablets thorn. 200mg 20 pcs.

248 r

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Anna Kozlova
Anna Kozlova

Anna Kozlova Medical journalist About the author

Education: Rostov State Medical University, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!

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