Aspirin-S - Instructions For Use Of Effervescent Tablets, Price, Analogues

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Aspirin-C

Aspirin-S: instructions for use and reviews

1. 1. Release form and composition
2. 2. Pharmacological properties
3. 3. Indications for use
4. 4. Contraindications
5. 5. Method of application and dosage
6. 6. Side effects
7. 7. Overdose
8. 8. Special instructions
9. 9. Application during pregnancy and lactation
10. 10. Use in childhood
11. 11. In case of impaired renal function
12. 12. For violations of liver function
13. 13. Drug interactions
14. 14. Analogs
15. 15. Terms and conditions of storage
16. 16. Terms of dispensing from pharmacies
17. 17. Reviews
18. 18. Price in pharmacies

Latin name: Aspirin-C

ATX code: N02BA51

Active ingredient: ascorbic acid (ascorbic acid) + acetylsalicylic acid (acetylsalicylic acid)

Producer: Bayer Bitterfeld (Germany)

Description and photo update: 2018-27-07

Aspirin-S is a combined preparation with analgesic, antipyretic, anti-inflammatory, regulating oxidation-reduction processes, increasing the body's resistance by action.

Release form and composition

The dosage form of Aspirin-C is effervescent tablets: white, round flat, beveled to the edge, on one side they have an imprint in the form of a trademark - "Bayer" cross (in a cardboard box there are 5 laminated paper strips of 2 tablets each).

Active ingredients in 1 tablet:

• acetylsalicylic acid - 400 mg;
• vitamin C (ascorbic acid) - 240 mg.

Auxiliary components: sodium carbonate - 200 mg, sodium citrate - 1206 mg, citric acid - 240 mg, sodium bicarbonate - 914 mg.

Pharmacological properties

Pharmacodynamics

Aspirin-C is one of the combined non-steroidal anti-inflammatory drugs. Its action is determined by the properties of the active ingredients:

• acetylsalicylic acid: has anti-inflammatory, antipyretic, analgesic properties, which is associated with the suppression of COX-1 and -2 (cyclooxygenase-1 and -2), which regulate the synthesis of prostaglandins; also acetylsalicylic acid inhibits platelet aggregation;
• ascorbic acid: a vitamin that helps to increase the body's resistance and is necessary for the regulation of many processes, including tissue regeneration, carbohydrate metabolism, redox processes, blood clotting.

Pharmacokinetics

Acetylsalicylic acid

After oral administration, it is rapidly and fully absorbed from the gastrointestinal tract. During / after absorption, salicylic acid is formed - the main active metabolite. The maximum plasma concentration of acetylsalicylic acid in the blood is reached in 10–20 minutes, for salicylates - 20–120 minutes.

The binding of acetylsalicylic and salicylic acids with blood plasma proteins is complete, they are quickly distributed in the body. Salicylic acid passes through the placenta and into breast milk.

Salicylic acid metabolism occurs mainly in the liver. Its main metabolites are gentisin uric acid, salicyl uric acid, salicylacil glucuronide, salicylphenol glucuronide, gentisic acid.

The metabolism of salicylic acid is limited by the activity of liver enzymes, therefore, the indicators of the kinetics of excretion are dose-dependent. The half-life also depends on the dose: when using low doses it is 2-3 hours, high - about 15 hours. The excretion of salicylic acid and its metabolites occurs mainly by the kidneys.

Vitamin C

After oral administration, absorption occurs in the intestine using a Na ⁺ -dependent active transport system, the most active process is observed in the proximal intestine.

The absorption of ascorbic acid is disproportionate to the dosage. With an increase in the daily dose, its plasma concentration in the blood and other body fluids does not proportionally increase, but tends to the upper limit.

Ascorbic acid is filtered through the glomeruli and reabsorbed under the influence of a Na ⁺ -dependent process by the proximal tubules. Excretion of the main metabolites in the form of diketogulonic acid and oxalates occurs in the urine.

Indications for use

• moderate / mild pain syndrome of various etiologies, including headache and toothache, migraine, neuralgia, pain during menstruation, muscle pain (adults);
• increased body temperature caused by colds and other infectious and inflammatory diseases (children from 15 years old and adults).

Contraindications

Absolute:

• gastrointestinal bleeding, a period of exacerbation of erosive and ulcerative lesions of the gastrointestinal tract;
• combination therapy with methotrexate at a dose of 15 mg per week;
• asthma associated with therapy with salicylates or other nonsteroidal anti-inflammatory drugs, in combination with nasal polyps;
• severe impairment of hepatic / renal function;
• hemophilia;
• thrombocytopenia;
• deficiency of glucose-6-phosphate dehydrogenase;
• hemorrhagic diathesis;
• I and III trimesters of pregnancy and the period of breastfeeding;
• age up to 15 years;
• individual intolerance to the components of the drug and other non-steroidal anti-inflammatory drugs.

Relative (Aspirin-C is prescribed under medical supervision):

• tendency to gastrointestinal bleeding;
• anemia;
• hypovitaminosis K;
• thyrotoxicosis;
• conditions in which the development of fluid retention in the body is possible, including dysfunctions of the heart, arterial hypertension;
• gout;
• concomitant anticoagulant therapy;
• erosive gastritis;
• burdened history of gastric ulcer and / or duodenal ulcer;
• hypoprothrombinemia;
• II trimester of pregnancy.

Instructions for the use of Aspirin-C: method and dosage

Aspirin-C is taken orally. The tablet must first be dissolved in 200 ml of water.

Single dose - 1 or 2 (maximum) tablets. The drug can be taken at intervals of at least four hours. The maximum daily dose is 6 tablets.

If there are no other doctor's prescriptions, the duration of therapy is determined by the indications and is:

• no more than 7 days - Aspirin-S is taken as an analgesic;
• no more than 3 days - Aspirin-S is taken as an antipyretic agent.

Side effects

• central nervous system: tinnitus, dizziness (as a rule, these disorders indicate an overdose);
• digestive system: vomiting, nausea, abdominal pain, obvious (bloody vomiting, black stools) or latent symptoms of gastrointestinal bleeding (can cause iron deficiency anemia), erosive and ulcerative lesions of the gastrointestinal tract (incl. perforation); rarely - violations of hepatic function (in the form of an increase in hepatic transaminases);
• urinary system: with high-dose therapy - damage to the glomerular apparatus of the kidneys, the formation of urinary stones from calcium oxalate and hyperoxaluria;
• hematopoietic system: thrombocytopenia, hemorrhagic syndrome;
• allergic reactions: bronchospasm, Quincke's edema, anaphylactic reactions, skin rash.

Overdose

The main symptoms are:

• initial stage: increased breathing, agitation of the central nervous system, vomiting, nausea, severe headache, dizziness, decreased hearing acuity, visual impairment;
• late symptoms: disorders of water and electrolyte metabolism, respiratory failure, drowsiness, anuria, convulsions, depression of consciousness up to coma.

Therapy: induce vomiting / gastric lavage, prescribe activated charcoal and laxative drugs. Treatment should be carried out in specialized departments.

special instructions

Due to the risk of Reye's syndrome (manifested in the form of encephalopathy and acute fatty degeneration of the liver with the rapid development of liver failure), Aspirin-C effervescent tablets are not prescribed for children under 15 years of age as an antipyretic agent for acute respiratory diseases caused by viral infections.

The action of acetylsalicylic acid is associated with a decrease in the excretion of uric acid from the body. If there is a predisposition, this can lead to the development of an acute attack of gout.

In cases of a long therapeutic course, it is recommended to periodically monitor the functional state of the liver, do a fecal occult blood test and a complete blood count.

Acetylsalicylic acid slows down blood clotting. Before carrying out a surgical intervention, a doctor must be warned about taking Aspirin-C.

Due to the likelihood of an increased risk of gastrointestinal bleeding during the period of therapy, alcohol is contraindicated.

One dose of Aspirin-C contains 933 mg of sodium, which should be taken into account by patients following a salt-free diet.

Application during pregnancy and lactation

• I and III trimesters of pregnancy, lactation period: therapy is contraindicated;
• II trimester of pregnancy: Aspirin-C can be used once in the recommended doses after the doctor assesses the ratio of the expected benefit to the possible risk.

Pediatric use

Aspirin-C effervescent tablets are contraindicated:

• up to 15 years - as an antipyretic agent;
• up to 18 years old - as an analgesic.

With impaired renal function

According to the instructions, Aspirin-C is contraindicated in case of severe renal dysfunction.

For violations of liver function

Aspirin-C therapy is contraindicated for severe liver dysfunction.

Drug interactions

Possible interactions:

• glucocorticosteroids, ethanol-containing drugs and ethanol: the damaging effect on the mucous membrane of the gastrointestinal tract of Aspirin-C and the likelihood of developing gastrointestinal bleeding increases;
• opioid analgesics, heparin, other non-steroidal anti-inflammatory drugs, thrombolytics and platelet aggregation inhibitors, oral hypoglycemic agents, indirect anticoagulants, sulfonamides (including co-trimoxazole), reserpine, triiodothyronine: their effects are enhanced;
• methotrexate: its toxicity increases;
• uricosuric drugs (sulfinpyrazone, benzbromarone), antihypertensive drugs and diuretics (furosemide, spironolactone): their effectiveness decreases;
• antacids containing magnesium / aluminum hydroxide: absorption of acetylsalicylic acid worsens and slows down;
• digoxin, barbiturates and lithium preparations: their plasma concentration increases;
• iron preparations: their absorption in the intestine is improved (due to ascorbic acid).

Analogs

Aspirin-C analogs are Aspinat C, Asprovit S.

Terms and conditions of storage

Store at temperatures up to 25 ° C. Keep out of the reach of children.

The shelf life is 3 years.

Terms of dispensing from pharmacies

Available without a prescription.

Reviews about Aspirin-S

According to reviews, Aspirin-C effectively relieves pain syndrome of various etiologies and symptoms of fever against the background of colds and infectious diseases. The drug is often used as a hangover cure. Its availability in pharmacies, pleasant taste, and ease of use are noted.

Opinions differ regarding the price. Many point out that the cost is acceptable, but some consider it too high. The disadvantages of Aspirin-C include a large number of contraindications for use, a negative effect on the gastrointestinal tract and the possibility of bleeding.

Price for Aspirin-S in pharmacies

The approximate price for Aspirin-S (10 effervescent tablets) is 238-425 rubles.

Anna Kozlova Medical journalist About the author

Education: Rostov State Medical University, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!