Aprovask
Instructions for use:
- 1. Release form and composition
- 2. Indications for use
- 3. Contraindications
- 4. Method of application and dosage
- 5. Side effects
- 6. Special instructions
- 7. Drug interactions
- 8. Analogs
- 9. Terms and conditions of storage
- 10. Terms of dispensing from pharmacies
Prices in online pharmacies:
from 408 rub.
Buy
Aprovask is a combined antihypertensive drug.
Release form and composition
Aprovask is available in the form of film-coated tablets:
- Aprovask 5 mg + 150 mg: oval, biconvex, white, on one side there is an engraving "150/5" (7 pieces in blisters, in a cardboard box 2 or 4 blisters);
- Aprovask 10 mg + 150 mg: oval, biconvex, pink, on one side there is an engraving "150/10" (7 pieces in blisters, in a cardboard box 2 or 4 blisters);
- Aprovask 5 mg + 300 mg: oval, biconvex, yellow, on one side there is an engraving "300/5" (7 pieces in blisters, in a cardboard box 2 or 4 blisters);
- Aprovask 10 mg + 300 mg: oval, biconvex, white, on one side there is a risk and a bevel to it (7 pieces in blisters, in a cardboard box 2 or 4 blisters).
Composition of 1 tablet:
- active ingredients: amlodipine (in the form of amlodipine besylate) - 5 or 10 mg; irbesartan - 150 or 300 mg;
- auxiliary components: hypromellose 6 mPa.s, colloidal silicon dioxide, microcrystalline cellulose 50 microns, microcrystalline cellulose 100 microns, magnesium stearate, sodium croscarmellose;
- composition of the film coat: white opadry (Aprovask 5 mg + 150 mg and Aprovask 10 mg + 300 mg), pink opadry (Aprovask 10 mg + 150 mg) or yellow opadry (Aprovask 5 mg + 300 mg)
Indications for use
Aprovask is prescribed for arterial hypertension in case of ineffectiveness of monotherapy with amlodipine or irbesartan.
Contraindications
Absolute:
- unstable angina (except for Prinzmetal's angina);
- cardiogenic shock;
- clinically significant aortic valve stenosis;
- simultaneous reception with angiotensin-converting enzyme inhibitors in patients with diabetic nephropathy;
- simultaneous administration with drugs, which include aliskiren, in persons with diabetes mellitus or renal failure of moderate or severe degree;
- children and adolescents up to 18 years of age (since the safety and effectiveness of the drug have not been established);
- period of pregnancy;
- lactation period;
- hypersensitivity to the main or auxiliary components of the drug, as well as other derivatives of dihydropyridine.
Relative (Aprovask is used with caution):
- chronic heart failure of functional class 2-3;
- mitral and aortic valve stenosis or hypertrophic obstructive cardiomyopathy;
- ischemic heart disease and / or clinically significant cerebral atherosclerosis;
- sick sinus syndrome;
- renal failure and the postoperative period after kidney transplantation;
- liver failure;
- hyponatremia and hypovolemia;
- conditions in which renal function depends on the activity of the renin-angiotensin-aldosterone system (arterial hypertension with renal artery stenosis of both kidneys or one kidney, chronic heart failure of functional class 3-4).
Method of administration and dosage
Aprovask is taken orally, regardless of the meal. The tablet should be swallowed whole with water.
As a rule, the initial and maintenance doses are 1 tablet per day.
Aprovask is prescribed for patients with ineffectiveness of monotherapy with amlodipine or irbesartan, as well as for those who are already taking amlodipine and irbesartan as separate drugs. The dose is selected individually, and first amlodipine and irbesartan are used separately. The dose selection takes into account the blood pressure response to the treatment and the target blood pressure value. The maximum daily dose of the drug is 150 mg / 10 mg or 300 mg / 10 mg.
Patients with impaired renal function and the elderly do not need dose reduction.
For violations of liver function, Aprovask is prescribed with caution.
Side effects
Undesirable side effects observed during treatment with Aprovask:
- digestive system: often - swelling of the gums; infrequently - pain in the upper abdomen, nausea, constipation;
- metabolism: infrequently - hyperkalemia;
- respiratory system: infrequently - cough;
- cardiovascular system: often - orthostatic hypotension, palpitations; infrequently - excessive decrease in blood pressure, sinus bradycardia;
- nervous system: often - drowsiness, headache, dizziness; infrequently - paresthesia;
- sense organs: infrequently - vertigo;
- musculoskeletal system: infrequently - arthralgia, joint stiffness, myalgia;
- urinary system: often - proteinuria; infrequently - hypercreatinemia, azotemia;
- reproductive system: infrequently - erectile dysfunction;
- other reactions: often - edema, peripheral edema; infrequently - asthenic state.
Undesirable side effects observed in clinical studies and post-marketing use of irbesartan:
- digestive system: often - pain in the upper abdomen, glossitis, nausea and vomiting, taste perversion; infrequently - heartburn, dyspepsia, diarrhea; frequency unknown - hepatitis, jaundice, increased activity of liver enzymes;
- metabolism: frequency unknown - hyperkalemia;
- respiratory system: infrequently - cough;
- cardiovascular system: infrequently - tachycardia;
- nervous system: often - dizziness, headache; infrequently - orthostatic dizziness;
- sense organs: often - vertigo; frequency unknown - tinnitus;
- musculoskeletal system: frequency unknown - myalgia;
- urinary system: frequency unknown - impaired renal function;
- reproductive system: infrequently - erectile dysfunction;
- skin and subcutaneous tissue: infrequently - baldness; frequency unknown - leukocytoclastic vasculitis;
- immune system: frequency unknown - urticaria, angioedema and other hypersensitivity reactions;
- other reactions: often - edema, increased fatigue; infrequently - falls, chest pains; frequency unknown - asthenic condition.
Undesirable side effects observed in clinical trials with the use of amlodipine:
- digestive system: often - abdominal pain, glossitis, nausea, glossodynia; infrequently - dyspepsia, dryness of the mucous membranes of the oral cavity, changes in the rhythm of bowel movements, vomiting; very rarely - jaundice, hepatitis, gastritis, pancreatitis, gingival hyperplasia, increased activity of liver enzymes;
- metabolism: very rarely - hyperglycemia;
- respiratory system: often - cough; infrequently - rhinitis, shortness of breath; very rarely - coughing;
- cardiovascular system: often - redness of the skin, hot flashes, palpitations; very rarely - heart rhythm disturbances, vasculitis, myocardial infarction, atrial fibrillation and ventricular tachycardia;
- nervous system and psyche: often - drowsiness, dizziness, headache; infrequently - mood lability, taste perversion, paresthesia, insomnia, syncope, tremor, hypesthesia; very rarely - peripheral neuropathy;
- sense organs: infrequently - vertigo, visual disturbances, ringing in the ears;
- musculoskeletal system: infrequently - myalgia, muscle cramps, back pain, arthralgia;
- urinary system: infrequently - painful urge to urinate, increased frequency of urination, nocturia;
- reproductive system: infrequently - gynecomastia, impotence;
- skin and subcutaneous tissue: often - contact dermatitis; infrequently - baldness, itching, increased sweating, skin rash, purpura, changes in skin pigmentation; very rarely - erythema multiforme exudative;
- immune system: very rarely - urticaria, angioedema and other allergic reactions;
- hematopoietic system: very rarely - thrombocytopenia;
- instrumental data and laboratory parameters: infrequently - decrease or increase in body weight;
- other reactions: often - edema, increased fatigue, peripheral edema; infrequently - asthenic state, pain, feeling of malaise, pain in the chest; rarely - facial edema.
special instructions
The effect of the drug Aprovask on a person's ability to drive vehicles or engage in work that requires increased concentration of attention and quick reactions has not been studied. Given the pharmacodynamic properties of the drug, its effect on this ability is unlikely. It is not recommended to drive a car or engage in potentially hazardous activities in the event of adverse reactions such as vertigo, dizziness and weakness.
Drug interactions
Studies on the interaction of the drug Aprovask with other drugs have not been conducted.
Consult your doctor before using other drugs concomitantly with irbesartan / amlodipine.
Analogs
There is no information about Aprovask's analogues.
Terms and conditions of storage
Store at a temperature not exceeding 30 ° C. Keep out of the reach of children.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Aprovask: prices in online pharmacies
|
Drug name Price Pharmacy |
|
Aprovask 5 mg + 150 mg film-coated tablets 28 pcs. 408 RUB Buy |
|
Aprovask 10 mg + 150 mg film-coated tablets 28 pcs. 450 RUB Buy |
|
Aprovask 5 mg + 300 mg film-coated tablets 28 pcs. RUB 500 Buy |
|
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Aprovask 10 mg + 300 mg film-coated tablets 28 pcs. 640 RUB Buy |
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Aprovask 5 mg + 150 mg film-coated tablets 56 pcs. 1039 RUB Buy |
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Aprovask pills p.p. 5mg + 150mg 56 pcs 1044 RUB Buy |
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Aprovask tablets p.p. 10mg + 300mg 56 pcs 1378 RUB Buy |
|
Aprovask 10 mg + 300 mg film-coated tablets 56 pcs. 1378 RUB Buy |
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Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
