Aldactone - Instructions For Use, Indications, Doses, Analogues

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Aldactone

Instructions for use:

1. 1. Release form and composition
2. 2. Indications for use
3. 3. Contraindications
4. 4. Method of application and dosage
5. 5. Side effects
6. 6. Special instructions
7. 7. Drug interactions
8. 8. Analogs
9. 9. Terms and conditions of storage
10. 10. Terms of dispensing from pharmacies

Aldactone is a potassium-sparing diuretic.

Release form and composition

• Film-coated tablets (10 pcs. In blisters, 2 blisters in a cardboard box);
• Solution for injection (5 or 10 ml in ampoules, 5 ampoules in blisters, 2 blisters in a cardboard box).

The active substance is spironolactone:

• 1 tablet - 25 or 100 mg;
• 1 ml of solution - 20 mg.

Indications for use

• Arterial hypertension;
• Primary and idiopathic hyperaldosteronism (treatment and diagnosis);
• Adenomas of the adrenal glands producing aldosterone (as part of combination therapy);
• Hypokalemia (treatment and prevention with the use of saluretics);
• Edema in nephrotic syndrome, liver cirrhosis (especially in the case of the concomitant presence of hypokalemia and hyperaldosteronism), chronic heart failure, nephropathy of pregnant women;
• Edema in the II and III trimesters of pregnancy;
• Malignant hypertension (as an adjuvant);
• Premenstrual syndrome;
• Polycystic ovary syndrome.

Contraindications

Absolute:

• Anuria;
• Hyperkalemia;
• Hyponatremia;
• Hypercalcemia;
• Addison's disease;
• Acute and chronic (with a significant decrease in renal function) renal failure;
• Liver failure;
• Diabetes mellitus in patients with chronic renal failure or if it is suspected;
• Diabetic nephropathy;
• Metabolic acidosis;
• Breast enlargement or menstrual irregularities;
• I trimester of pregnancy;
• Hypersensitivity to the drug.

Relative:

• AV block;
• Decompensated liver cirrhosis;
• Surgical interventions;
• Elderly age;
• The use of local and general anesthetics;
• Concomitant use of drugs that can cause gynecomastia.

Method of administration and dosage

The doctor sets the dose of the drug individually, depending on the hormonal status and the severity of violations of water-electrolyte metabolism.

In the form of a solution, Aldactone is administered intravenously at 100-200 mg (1-2 ampoules) per day for 3-5 days. The maximum daily dose is 800 mg.

In the form of tablets, the drug should be taken orally. Recommended doses for adults:

• Primary hyperaldosteronism: during preparation for surgery - 100-400 mg per day; in case of refusal from the operation, the patient is selected the minimum effective dose;
• Edema (renal, hepatic and cardiac origin): the initial daily dose is 100 mg in several doses, after 5 days, depending on the achieved clinical effect and the concentration of potassium in the blood plasma, the dose is increased to 200 mg or reduced to 25 mg. The duration of treatment is 14-21 days. If necessary, courses are repeated at intervals of 10-14 days;
• Diuretic-induced hypokalemia: 25-100 mg per day;
• Arterial hypertension: the initial daily dose is 50-100 mg in several doses, after 2 weeks, depending on the effect, the dose may be reduced or increased.

For children, Aldactone is prescribed in a daily dose calculated taking into account weight - 3.3 mg / kg.

Side effects

• From the side of the central nervous system: dizziness, lethargy, drowsiness, headache, lethargy, ataxia;
• From the digestive system: diarrhea or constipation, abdominal pain, nausea, gastritis, vomiting, ulceration and bleeding in the gastrointestinal tract, intestinal colic;
• From the hematopoietic system: thrombocytopenia, megaloblastosis, agranulocytosis;
• From the side of metabolism: hyperuricemia, hypercreatininemia, increased urea concentration, disturbances in water-salt metabolism and acid-base balance (metabolic hypochloremic acidosis, alkalosis);
• From the endocrine system: in women - hirsutism, soreness of the mammary glands, coarsening of the voice, amenorrhea, dysmenorrhea, metrorrhagia in the climacteric period, breast carcinoma; in men with prolonged use - erectile dysfunction, gynecomastia;
• Allergic reactions: itching, urticaria, drug fever, maculopapular and erythematous rashes;
• Others: muscle spasms, decreased potency.

special instructions

During treatment, you should periodically determine the content of urea and electrolytes in the blood.

Simultaneously with Aldactone, potassium-containing drugs and other diuretics should not be prescribed that cause potassium retention in the body. It is recommended to refrain from using carbenoxolone, because it causes sodium retention.

If necessary, the combined use of spironolactone with antihypertensive drugs or other diuretics should reduce the dose of the latter. The same goes for the simultaneous use of digoxin.

Drug interactions

• Antihypertensive drugs: the antihypertensive effect of spironolactone is potentiated;
• Potassium preparations, other potassium-sparing diuretics, table salt substitutes, potassium-containing biologically active food additives, as well as losartan, candesartan and eprosartan: the risk of hyperkalemia increases;
• Mefenamic acid, indomethacin: excretion of canrenone (active metabolite of spironolactone) by the kidneys is inhibited;
• Salicylates: the diuretic effect of Aldactone decreases;
• Digoxin: it is possible to decrease or increase its effects;
• Oral anticoagulants: its hypoprothrombinemic effect decreases;
• Lithium carbonate: the concentration of lithium in the blood plasma may increase;
• Cholestyramine: there is a risk of developing hypochloremic alkalosis;
• Triptorelin, gonadorelin, buserelin: their effect is enhanced;
• Norepinephrine: the sensitivity of the vessels to its action may decrease;
• Angiotensin-converting enzyme inhibitors: Increases the likelihood of developing hyperkalemia, especially with concomitant renal dysfunction.

Analogs

Analogs of Aldactone are: Veroshpiron, Veroshpilactone, Vero-Spironolactone, Spironolactone.

Terms and conditions of storage

Store in a dry (tablets), protected from light and out of reach of children at a temperature: tablets - up to 30 ºС, solution - up to 25 ºС.

The shelf life is 5 years.

Terms of dispensing from pharmacies

Dispensed by prescription.

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!