Feniprex-S
Feniprex-S: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Use in the elderly
- 14. Drug interactions
- 15. Analogs
- 16. Terms and conditions of storage
- 17. Terms of dispensing from pharmacies
- 18. Reviews
- 19. Price in pharmacies
Latin name: Phenyprecs-C
ATX code: N02BE51
Active ingredient: paracetamol (Paracetamol) + phenylephrine (Phenylephrine) + ascorbic acid (Ascorbic acid)
Manufacturer: CJSC "Moscow Pharmaceutical Factory" (Russia)
Description and photo update: 2020-10-03
Feniprex-S is a combined drug for the elimination of symptoms of influenza, acute respiratory viral infections (ARVI) and colds.
Release form and composition
The dosage form of the drug is a powder for preparation of a solution for oral administration: it has a color from white to light yellow with a pink tint, has a specific aroma; when dissolved in water, it forms a pink liquid (5 g each in heat-sealable bags, in a box made of cardboard box 5 or 10 bags and instructions for use of Feniprex-S).
Composition for 1 package (5000 mg):
- active ingredients: paracetamol - 500 mg; ascorbic acid - 300 mg; phenylephrine hydrochloride - 10 mg;
- auxiliary components: flavoring "Raspberry 909" - 50 mg; kollidon 30 - 2 mg; sodium saccharinate - 50 mg; refined sugar (refined powder) - 4088 mg.
Pharmacological properties
Feniprex-S is a combination drug intended for the symptomatic treatment of influenza, acute respiratory viral infections and colds.
The effectiveness of the drug is provided by the properties of its active ingredients:
- paracetamol (non-narcotic analgesic and antipyretic): has antipyretic and analgesic efficacy;
- phenylephrine (vasoconstrictor adrenomimetic): facilitates breathing, exerting a vasoconstrictor effect and reducing swelling of the nasopharyngeal mucosa;
- ascorbic acid (vitamin C): replenishes the body's increased need for vitamin C in case of flu and colds.
Indications for use
Pheniprex-S is recommended to be taken to eliminate symptoms of flu and colds such as pain in the sinuses and throat, headache, joint and muscle pain, fever, chills, nasal congestion.
Contraindications
Absolute:
- hyperthyroidism (thyrotoxicosis);
- severe impairment of hepatic / renal function;
- severe aortic stenosis, tachyarrhythmias, acute myocardial infarction, other heart diseases;
- hypertonic disease;
- angle-closure glaucoma;
- simultaneous administration with tricyclic antidepressants, beta-blockers, monoamine oxidase inhibitors (MAO), including a period up to 2 weeks after their cancellation;
- taking ascorbic acid, other medicines containing paracetamol, medicines to relieve the symptoms of flu, colds, nasal congestion;
- prostate adenoma;
- children and adolescents under 18 years of age;
- rare genetic diseases: fructose intolerance, sucrase / isomaltase deficiency, glucose-galactose malabsorption;
- hypersensitivity to active or auxiliary components of the drug.
Relative contraindications for which Pheniprex-S powder must be taken with caution:
- genetic absence of glucose-6-phosphate dehydrogenase;
- benign hyperbilirubinemia (including Gilbert's syndrome);
- viral hepatitis;
- impaired hepatic / renal function;
- alcoholic liver damage or alcoholism;
- hemochromatosis;
- sideroblastic anemia;
- thalassemia;
- hyperoxaluria, oxalosis;
- kidney stone disease;
- diabetes;
- elderly age;
- pregnancy and breastfeeding.
Feniprex-S, instructions for use: method and dosage
A solution prepared from Feniprex-S powder is intended for oral administration.
The recommended dosing regimen for adult patients: one sachet every 4-6 hours. The maximum daily dose is 4 sachets. Do not take the solution more often than once every 4 hours.
To prepare the solution, the contents of one sachet are poured into 200 ml of hot boiled water, stirred until completely dissolved, if desired, add cold boiled water and / or sugar.
Pheniprex-S should not be used without consulting a doctor as a pain reliever - for more than 5 days in a row, as an antipyretic - for more than 3 days.
If symptoms persist while taking the drug, specialist advice is required.
Do not exceed the indicated dose. In case of an overdose, it is important to seek immediate medical attention, even if you feel well, as there is a high risk of developing delayed signs of serious liver dysfunction.
Side effects
Reception of Feniprex-S can contribute to the development of negative side reactions due to individual active components of the drug:
- paracetamol: possible hypersensitivity reactions (urticaria, skin rash, angioedema); in rare cases - leukopenia, thrombocytopenia, agranulocytosis;
- phenylephrine: nausea, headache, slight increase in blood pressure; in rare cases - palpitations (after discontinuation of the drug, side effects disappear);
- ascorbic acid: irritation of the mucous membrane of the digestive tract, hyperprothrombinemia, thrombocytosis, erythropenia, hypokalemia, glucosuria, neutrophilic leukocytosis, moderate pollakiuria.
Long-term use of Feniprex-S in doses significantly higher than recommended increases the likelihood of impaired liver / kidney function.
If you experience any unwanted side reactions, you need to see a doctor.
Overdose
An overdose of Feniprex-C is most often caused by paracetamol.
Symptoms:
- the first 24 hours after administration: anorexia, pallor of the skin, nausea, vomiting, hepatonecrosis, abdominal pain, increased activity of liver enzymes, increased prothrombin time, metabolic acidosis, impaired glucose metabolism;
- severe intoxication: arrhythmia, acute failure of renal function with tubular necrosis (including without severe liver damage), pancreatitis, hepatic failure with progressive encephalopathy, coma, death. The hepatotoxic effect in adults is manifested in the case of taking 10,000 mg of paracetamol or more. Suspected poisoning requires immediate medical attention.
In case of an overdose, the patient is recommended to perform gastric lavage followed by the intake of activated carbon, after which symptomatic therapy is carried out.
A specific antidote to paracetamol is acetylcysteine.
special instructions
To minimize the likelihood of toxic liver damage, paracetamol should not be taken simultaneously with alcoholic beverages, as well as people prone to chronic alcohol use.
Pheniprex-S gives false laboratory test results to assess plasma levels of uric acid and glucose.
Taking ascorbic acid in high doses increases the excretion of oxalate, thereby promoting the formation of kidney stones.
It is possible to develop rebound scurvy in newborns whose mothers took high doses of vitamin C during pregnancy, and in adult patients who also took high doses of ascorbic acid.
Ascorbic acid has a stimulating effect on the synthesis of corticosteroid hormones, in connection with which it is necessary to monitor the function of the adrenal glands and blood pressure.
Prolonged use of large doses can inhibit the functional activity of the insular apparatus of the pancreas, and therefore requires regular monitoring during therapy.
With an increased content of iron in the body, ascorbic acid should be used in minimal doses.
The regenerative effect of ascorbic acid can distort the data of various laboratory tests (determination of the concentration of glucose in the blood and urine, the level of bilirubin, the activity of lactate dehydrogenase and hepatic transaminases).
1 sachet of Feniprex-S contains approximately 4000 mg of sugar, which corresponds to 0.4 XE (bread unit).
Influence on the ability to drive vehicles and complex mechanisms
During therapy with Feniprex-S, one should refrain from driving vehicles and engaging in other potentially hazardous activities that require a quick psychomotor reaction and increased concentration.
Application during pregnancy and lactation
Pregnant women and women who are breastfeeding can only take Pheniprex-S as directed by a doctor.
Pediatric use
The use of Feniprex-S in pediatric practice is contraindicated.
With impaired renal function
Pheniprex-S is used with caution in case of renal dysfunction.
In case of severe renal dysfunction, the drug is not used.
For violations of liver function
Pheniprex-S is used with caution in case of hepatic dysfunction.
In case of severe liver dysfunction, the drug is not used.
Use in the elderly
Elderly patients should take the drug with caution.
Drug interactions
Possible pharmacological interaction of paracetamol with other substances / drugs:
- uricosuric drugs: paracetamol reduces their effectiveness;
- anticoagulants: the concomitant use of high doses of paracetamol increases the effect of reducing the synthesis of procoagulant factors in the liver;
- microsomal oxidation inducers (barbiturates, phenytoin, rifampicin, tricyclic antidepressants, phenylbutazone), hepatotoxic drugs, ethanol: increase the production of hydroxylated active metabolites, increasing the likelihood of severe intoxication even in the case of a small overdose. Prolonged use with barbiturates reduces the effectiveness of paracetamol. Ethanol in combination with paracetamol contributes to the development of acute pancreatitis;
- inhibitors of microsomal oxidation (cimetidine): reduce the hepatotoxic effect of paracetamol;
- non-steroidal anti-inflammatory drugs (NSAIDs): with prolonged joint use with paracetamol, they increase the risk of developing analgesic nephropathy and renal papillary necrosis, the onset of end-stage renal failure;
- salicylates: when taken with high doses of paracetamol, increase the risk of developing cancer of the bladder and / or kidney;
- diflunisal: increases the plasma level of paracetamol by 50%, increasing the risk of developing hepatotoxicity;
- myelotoxic drugs: aggravate hematotoxicity.
Possible pharmacological interaction of phenylephrine with other substances / drugs:
- diuretics and antihypertensive drugs (methyldopa, mecamylamine, guanadrel, guanethidine): phenylephrine reduces their hypotensive effect;
- phenothiazines, furosemide, alpha-blockers (phentolamine), other diuretics: reduce the vasoconstrictor effect of phenylephrine;
- methylphenidate, MAO inhibitors (procarbazine, selegiline, furazolidone), ergot alkaloids, oxytocin, adrenostimulants, tricyclic antidepressants: stimulate the pressor efficiency and arrhythmogenicity of phenylephrine;
- beta-blockers: their cardiac stimulating effect is weakened;
- reserpine: as a result of depletion of catecholamine reserves, sensitivity to adrenomimetics in adrenergic endings increases, possibly the development of arterial hypertension;
- inhalation anesthetics (halothane, chloroform, enflurane, isoflurane, methoxyflurane): sharply increase the sensitivity of the myocardium to sympathomimetics, which increases the risk of developing severe atrial / ventricular arrhythmia;
- ergotamine, ergometrine, methylergometrine, doxapram, oxytocin: the severity of their vasoconstrictor action increases;
- nitrates: phenylephrine reduces their antianginal effect, they, in turn, are able to reduce the pressor effect of sympathomimetics and the risk of developing arterial hypotension (simultaneous use is permissible depending on the achievement of the required therapeutic effect);
- thyroid hormones: the effect and the associated risk of coronary insufficiency are mutually reinforced (especially in patients with coronary atherosclerosis).
Possible pharmacological interaction of ascorbic acid
with other substances / drugs:
- benzylpenicillin and tetracyclines: their concentration in the blood increases;
- ethinylestradiol (including part of oral contraceptives): when used with ascorbic acid in a daily dose of 1000 mg, its bioavailability increases;
- iron preparations: their absorption in the intestine improves, ascorbic acid converts trivalent iron into bivalent;
- deferoxamine: iron excretion may be accelerated;
- heparin and indirect anticoagulants: their effectiveness decreases;
- ASA (acetylsalicylic acid), oral contraceptives, fresh juices and alkaline drinks: reduce absorption and assimilation of ascorbic acid. ASA increases the excretion of ascorbic acid in the urine and reduces its absorption by about 30%, while the excretion of ASA decreases;
- short-acting salicylates and sulfonamides: the risk of crystalluria increases, since the excretion of acids by the kidneys slows down;
- alkaline substances (including alkaloids): their excretion increases;
- oral contraceptives: ascorbic acid reduces their concentration in the blood;
- ethanol: its total clearance increases, while the concentration of ascorbic acid in the body decreases;
- quinolines, calcium chloride, salicylates, glucocorticosteroids: long-term use of these agents depletes the reserves of ascorbic acid;
- isoprenaline: its chronotropic effect decreases;
- disulfiram and ethanol: long-term use or use of high doses of ascorbic acid may interfere with their interaction;
- mexiletine: high doses of ascorbic acid accelerate its excretion by the kidneys;
- barbiturates and primidone: accelerate the elimination of ascorbic acid in the urine;
- antipsychotic drugs (neuroleptics), phenothiazine derivatives: their therapeutic effect is weakened;
- amphetamine and tricyclic antidepressants: their tubular reabsorption decreases.
Analogs
Feniprex-S analogs are AntiFlu, Gripand HotActive, Gripand HotActive Max, Influnet, Coldact with vitamin C, Coldrex FLU Plus, Coldrex HotRem, Coldfree, Lemsip Blackcurrant, Flucoldex, etc.
Terms and conditions of storage
Store in a dry place at temperatures up to 25 ° C. Keep out of the reach of children.
Shelf life is 2 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Feniprex-S
Patients in most reviews of Feniprex-S note its effective effect on colds, flu and viral infection. The drink prepared from the powder tastes good, quickly relieves symptoms, is partially anesthetic, and also contains vitamin C. For some users, it is the most effective remedy for colds, while it is inexpensive.
Sometimes they point to such disadvantages as the presence of a fragrance in the composition, possible drowsiness after taking it, and an extensive list of contraindications. In addition, Feniprex-S does not relieve severe nasal congestion, and the relief of the condition lasts only 2 hours.
Price for Feniprex-S in pharmacies
The approximate price of Feniprex-S, a powder for preparing a solution for oral administration, for a package of 10 sachets of 5 g each is 65 rubles.
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
