Fevarin
Instructions for use:
- 1. Indications for use
- 2. Method of application, dosage
- 3. Contraindications to use
- 4. Side effects
- 5. Application during pregnancy
- 6. Interaction with other drugs
- 7. Overdose
- 8. Reviews
- 9. Analogs
- 10. Storage conditions
Prices in online pharmacies:
from 827 rub.
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Fevarin is a drug from the group of antidepressants that selectively inhibits serotonin reuptake. The active ingredient - fluvoxamine - selectively blocks the seizure of serotonin by neurons in the brain. Fevarin practically does not affect the metabolic processes of norepinephrine, has a weak affinity for adrenergic receptors, serotonin, dopamine, histamine and cholinergic receptors. Reviews of Fevarin by neuropsychiatric specialists speak of the high effectiveness of this drug.
When taken orally, Fevarin is well absorbed in the gastrointestinal tract. Has the effect of the first passage through the liver. Bioavailability - 53%. The food intake does not affect the rate of absorption of Fevarin, as well as its bioavailability. The maximum plasma concentration is reached 3-8 hours after administration. Fevarin binds to plasma proteins in an amount of more than 80%. Metabolized in the liver.
The half-life is 13-18 hours. In the form of metabolites, it is excreted by the kidneys.
With liver pathology, the metabolism of the drug slows down.
Indications to Fevarin's use
The instructions for Fevarin indicate that this drug is used for depression of various etiologies, obsessive-compulsive disorders.
Method of application, dosage
Fevarin is intended for oral administration. The tablet should be swallowed whole without crushing. The maximum daily dosage is 300mg. The daily dose is usually given in one dose. The drug is recommended to be taken in the evening, if necessary, dividing the dose - in the morning and in the evening. The dosage and duration of the course of therapy in each individual case is determined by the doctor.
The average daily dosage for the treatment of depression in adult patients is 50-100 mg. If the therapeutic effect is insufficient, the dosage is increased gradually. When a clinical effect is achieved for the prevention of relapses, it is recommended to continue treatment for at least six months.
The dosage of Fevarin for the prevention of relapses in the treatment of depressive disorders is 100 mg.
The dosage for the treatment of obsessive-compulsive disorders is 50mg. If the effect is insufficient, the dosage is increased after 2-3 days. The maximum dosage for this pathology is also 300 mg.
The daily dosage of Fevarin for children 8-18 years old is 25 mg. With insufficient clinical effect, it is possible to increase the indicated dosage in 2-3 days. The maximum daily dosage is 200mg. If there is no effect after 10 weeks, the drug must be canceled.
According to the instructions, Fevarin for liver pathology must be prescribed in the minimum clinically effective dosage. When the dosage is increased for several days, the patient should be under medical supervision.
Contraindications to the use of Fevarin
The instructions for Fevarin indicate the following contraindications:
- increased individual sensitivity to fluvoxamine;
- simultaneous treatment with monoamine oxidase inhibitors, tizanidine;
- alcoholism;
- age up to 8 years due to the lack of sufficient experience in using Fevarin in this age category;
- severe pathology of the kidneys and liver, epilepsy, bleeding tendency.
Side effects of Fevarin
When taking this drug, a large number of side effects may develop, which often causes negative reviews about Fevarin from patients who have used this drug. The following side effects of Fevarin have been registered:
- from the gastrointestinal tract: vomiting, nausea, epigastric pain, impaired appetite, dryness of the oral mucosa, impaired stool, increased levels of liver enzymes;
- from the side of the central nervous system and peripheral nervous system: headache, weakness, dizziness, agitation, anxiety, tremor, ataxia, disturbance of sleep and wakefulness, extrapyramidal disorders;
- from the cardiovascular system: decreased heart rate, heart rhythm disturbances, postural hypotension, palpitations;
- allergic reactions: urticaria, itching, angioedema, photosensitivity;
- others: muscle and joint pain, sexual dysfunction, increased sweating, galactorrhea, urinary disorders, changes in body weight.
When taking Fevarin and analogues, hyponatremia may occur, which passes after the drug is discontinued.
The development of serotonin syndrome (muscle stiffness, increased body temperature, changes in the psyche, coma, lability of the autonomic nervous system) was extremely rare.
To prevent side effects, Fevarin should be taken under medical supervision and only as directed by the attending physician.
Fevarin's use during pregnancy
There is not enough data on the effect of the drug on the fetus. In cases where the expected benefit to the mother significantly outweighs the possible risks to the fetus, Fevarin can be prescribed during pregnancy. With Fevarin therapy in the third trimester of pregnancy, careful monitoring of the condition of the newborn is necessary, due to the risk of withdrawal syndrome.
Interaction of Fevarin with other drugs
The simultaneous use of Fevarin and hypoglycemic drugs requires correction of the dosage of the latter.
It is contraindicated to take Fevarin and analogs simultaneously with MAO inhibitors.
The drug changes the pharmacokinetics of terfenadine, cisapride, astemizole, theophylline, mexiletine, methadone, carbamazepine, phenytoin.
Fevarin increases the concentration in blood of caffeine, warfarin, propranolol, midazolam, ropinirole, diazepam.
The combination of Fevarin with ethanol is contraindicated.
Overdose
In case of an overdose of Fevarin, signs of pathology of the gastrointestinal tract, CVS, and the nervous system appear: vomiting, nausea, weakness, sleep disturbance, decreased blood pressure, disturbed heart rhythm, convulsions, liver failure. There is no specific antidote. It is recommended to wash the stomach, take enterosorbents and carry out symptomatic treatment. Hemodialysis, forced diuresis with an overdose of Fevarin are not effective.
Reviews
Due to the high effectiveness of this drug, the reviews about Fevarin from the doctors are positive. Reviews about Fevarin from patients also speak of a good clinical effect of the drug, however, Fevarin has many side effects, the development of which can be prevented or minimized with constant medical supervision and adequate dosage selection.
Fevarin's analogs
The following Fevarin analogs are found: Deprivox, Fluvoxamine.
Storage conditions
The drug Fevarin should be stored at room temperature. The drug should be stored away from sunlight and out of the reach of children.
Before using the drug, you must carefully study the instructions for Fevarin.
Fevarin and analogues can only be used as directed by a doctor.
Fevarin: prices in online pharmacies
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Drug name Price Pharmacy |
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Fevarin 50 mg film-coated tablets 15 pcs. 827 RUB Buy |
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Fevarin tablets p.p. 50mg 15 Pcs. 909 RUB Buy |
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Fevarin 100 mg film-coated tablets 15 pcs. 1221 RUB Buy |
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Fevarin 100 mg film-coated tablets 30 pcs. 1936 RUB Buy |
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Fevarin tablets p.p. 100mg 30 pcs. 2207 RUB Buy |
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
