Paracetamol MS - Instructions For Use, Reviews, Price, Analogues

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Paracetamol MS

Paracetamol MS: instructions for use and reviews

1. 1. Release form and composition
2. 2. Pharmacological properties
3. 3. Indications for use
4. 4. Contraindications
5. 5. Method of application and dosage
6. 6. Side effects
7. 7. Overdose
8. 8. Special instructions
9. 9. Application during pregnancy and lactation
10. 10. Use in childhood
11. 11. In case of impaired renal function
12. 12. For violations of liver function
13. 13. Use in the elderly
14. 14. Drug interactions
15. 15. Analogs
16. 16. Terms and conditions of storage
17. 17. Terms of dispensing from pharmacies
18. 18. Reviews
19. 19. Price in pharmacies

Latin name: Paracetamol MS

ATX code: N02BE01

Active ingredient: paracetamol (paracetamol)

Manufacturer: Medisorb, CJSC (Russia)

Description and photo updated: 22.11.2018

Prices in pharmacies: from 4 rubles.

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Paracetamol MS is an analgesic non-narcotic drug.

Release form and composition

Paracetamol MS is available in the form of tablets: flat-cylindrical, white with a cream shade or white, with a dividing line and a chamfer (200 mg and 500 mg each: 10 pcs. In blisters or bezelzheykovyh packaging, in a cardboard box 1, 2, 5 or 10 packs).

1 tablet contains:

• active substance: paracetamol - 200 mg or 500 mg;
• auxiliary components: potato starch, stearic acid, low molecular weight polyvinylpyrrolidone (povidone), talc.

Pharmacological properties

Pharmacodynamics

Paracetamol is a non-narcotic analgesic, the mechanism of action of which is due to the inhibition of the synthesis of prostaglandins and a decrease in their effect on the center of thermoregulation in the hypothalamus. The tablets have an analgesic and antipyretic effect, exhibit insignificant anti-inflammatory activity.

Pharmacokinetics

When taken orally, paracetamol is rapidly absorbed from the gastrointestinal tract. Its maximum concentration in blood plasma is reached in 20-60 minutes and is 0.005-0.02 mg / ml.

Plasma protein binding - 15% of the dose taken.

Paracetamol crosses the blood-brain and placental barriers, is excreted in breast milk (less than 1% of the dose taken by the mother).

The optimal therapeutic effect is provided by the concentration of paracetamol in plasma, achieved from taking a single dose of 10–15 mg per 1 kg of patient weight.

Paracetamol metabolism occurs with the participation of microsomal liver enzymes (90–95%), including the CYP2E1 isoenzyme. Most (80%) of metabolites as a result of conjugation with glucuronic acid and sulfates are converted into inactive metabolites, 17% as a result of hydroxylation form 8 active metabolites, which after conjugation with glutathione are converted into inactive metabolites. With a deficiency of glutathione, active metabolites, blocking the enzyme systems of hepatocytes, can cause their necrosis.

It is excreted through the kidneys in unchanged form - 3%, the rest - in the form of metabolites, mainly conjugates.

The half-life (T _1/2) is 1–4 hours.

In elderly patients, the clearance of the drug decreases, T _1/2 - increases.

Indications for use

According to the instructions, Paracetamol MS is indicated for symptomatic therapy aimed at reducing pain and inflammation in the following conditions:

• mild or moderate pain (sore throat, toothache and headache, migraine pain, neuralgia and myalgia);
• increased body temperature with infectious and inflammatory diseases, including colds.

The drug does not affect the progression of the disease.

Contraindications

• genetic absence of glucose-6-phosphate dehydrogenase;
• severe liver dysfunction;
• blood diseases;
• severe renal impairment;
• confirmed hyperkalemia;
• period after coronary artery bypass grafting;
• active phase of gastrointestinal bleeding;
• erosive and ulcerative lesions of the mucous membrane of the stomach and duodenum;
• intestinal diseases of inflammatory etiology;
• period of pregnancy;
• breast-feeding;
• age up to 3 years;
• hypersensitivity to acetylsalicylic acid or nonsteroidal anti-inflammatory drugs (NSAIDs), accompanied by rhinitis, bronchial obstruction, urticaria (including history);
• individual intolerance to the components of the drug.

Paracetamol MS should be taken with caution in case of liver dysfunction, Gilbert's syndrome (constitutional hyperbilirubinemia), renal dysfunction with creatinine clearance (CC) less than 60 ml / min, diabetes mellitus, ischemic heart disease, chronic heart failure, cerebrovascular pathologies, peripheral arterial diseases, dyslipidemia or hyperlipidemia, history of ulcerative lesions of the gastrointestinal tract, Helicobacter pylori infection, long-term treatment with NSAIDs, severe somatic diseases, smoking, frequent alcohol consumption, in old age.

In addition, caution should be exercised in patients who are on concomitant therapy with oral glucocorticosteroids (including prednisolone), anticoagulants (including warfarin), selective serotonin reuptake inhibitors (including citalopram, paroxetine, fluoxetine, sertraline), antiaggregalicilic acid (including acidylacetylulophenyl), antiaggrellicylates (including acidic acidogrellulopidoglycelium).

Instructions for the use of Paracetamol MS: method and dosage

Paracetamol MS tablets are taken orally.

The recommended dosage has the following age restrictions:

• adults: 200 mg or 500 mg 1-4 times a day. The maximum single dose is no more than 1000 mg, the daily dose is 4000 mg;
• children: at the rate of 10-15 mg per 1 kg of the child's weight 4 times a day with an interval of 6 hours. Maximum daily dose: under the age of 6 years (weight up to 22 kg) - 1000 mg, up to 9 years (weight up to 30 kg) - 1500 mg, up to 12 years (weight up to 40 kg) - 2000 mg.

Duration of use: as an anesthetic - no more than 5 days, to lower high body temperature - no more than 3 days.

If you need to increase the daily dose or extend the course of treatment, you should consult a doctor.

Side effects

• from the digestive system: it is possible (with prolonged use of high doses of Paracetamol MS) - toxic liver damage;
• from the hematopoietic system: in rare cases - leukopenia, agranulocytosis, thrombocytopenia;
• on the part of the excretory system: possibly (with prolonged use of high doses of the drug) - nephrotoxic effect;
• on the part of the immune system: it is possible - the development of allergic reactions of a systemic nature or in the form of skin rashes.

Overdose

Symptoms: acute period - nausea, stomach pain, vomiting; after a few days - the appearance of signs of liver damage in the form of liver failure, encephalopathy, coma.

Treatment: immediate gastric lavage, intake of activated charcoal, after which you should seek medical attention.

special instructions

In therapeutic doses, Paracetamol MS is usually well tolerated by patients.

The use of alcoholic beverages and oral administration of ethanol-containing drugs during the treatment period are contraindicated. In persons prone to chronic alcoholism, taking paracetamol can cause toxic liver damage.

Paracetamol MS distorts the indicators of glucose and uric acid during laboratory tests to determine their amount in blood plasma.

If it is necessary to conduct a long course of therapy, control of the functional state of the liver and the picture of peripheral blood should be ensured.

Application during pregnancy and lactation

The use of Paracetamol MS is contraindicated during gestation and during breastfeeding.

Pediatric use

Do not use Paracetamol MS to treat children under the age of three.

When treating children, it is recommended to use special dosage forms of paracetamol for children.

With impaired renal function

It is contraindicated to take Paracetamol MS in severe renal impairment.

The drug should be taken with caution in case of impaired renal function with CC less than 60 ml / min.

For violations of liver function

It is contraindicated to use Paracetamol MS for the treatment of patients with severe liver dysfunction.

Care should be taken if liver function is impaired.

Use in the elderly

The drug should be taken with caution in old age.

Drug interactions

With the simultaneous use of Paracetamol MS:

• barbiturates, diphenin, carbamazepine, rifampicin, zidovudine and other inducers of liver microsomal enzymes increase the risk of developing the hepatotoxic effect of the drug;
• cimetidine and other inhibitors of microsomal oxidation help to reduce the hepatotoxic effect of paracetamol;
• anticoagulants enhance their effect against the background of the use of high doses of the drug;
• ethanol causes the development of acute pancreatitis;
• uricosuric agents reduce their therapeutic effect;
• NSAIDs with a joint long course of therapy increase the risk of developing analgesic nephropathy, renal papillary necrosis, followed by the onset of end-stage renal failure;
• Diflunisal increases the concentration of paracetamol in blood plasma by 50%, increasing the risk of hepatotoxicity;
• myelotoxic drugs increase the hematotoxic manifestations of the drug;
• salicylates with long-term use of high doses of the drug increase the risk of bladder or kidney cancer.

Analogs

Paracetamol MS analogs are: Paracetamol UBF, Paracetamol 325, Paracetamol Extratab, Ifimol, Strimol, Efferalgan, Perfalgan, Cefekon D, Flutabs, Kaffetin, Panadol Extra, Antigrippin, Antiflu, Fervex, Coldrex, Teradeflu, Maxalmax

Terms and conditions of storage

Keep out of the reach of children.

Store at temperatures up to 25 ° C, protected from moisture and light.

The shelf life is 3 years.

Terms of dispensing from pharmacies

Available without a prescription.

Reviews of Paracetamol MS

Reviews of Paracetamol MS are mostly positive. All patients point to a quick effect when using pills to relieve pain in headache and toothache, to reduce high body temperature in case of colds. The drug is well tolerated, rarely causes side effects. A very affordable price with high quality is often noted, compared with new expensive products that include paracetamol.

Since Paracetamol MS is dispensed without a prescription, the doctors' comments point out the advisability of using the drug only for symptomatic therapy, having accurately calculated the required dose, and for the treatment of the main cold, a doctor's consultation is necessary. They warn parents that lowering the temperature is not always justified.

Price for Paracetamol MS in pharmacies

The price of Paracetamol MS for a package containing 20 tablets in a dose of 500 mg can be 15-17 rubles.

Paracetamol MS: prices in online pharmacies

Drug name Price Pharmacy

Paracetamol MS 500 mg tablets 10 pcs. RUB 4 Buy

Paracetamol MS 500 mg tablets 20 pcs. RUB 14 Buy

Anna Kozlova Medical journalist About the author

Education: Rostov State Medical University, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!