Sulgin Avexima
Sulgin Avexima: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. Drug interactions
- 13. Analogs
- 14. Terms and conditions of storage
- 15. Terms of dispensing from pharmacies
- 16. Reviews
- 17. Price in pharmacies
Latin name: Sulgin Avexima
ATX code: A07AB03
Active ingredient: sulfaguanidine (Sulfaguanidine)
Producer: Irbitsky KhFZ, JSC (Russia)
Description and photo update: 2020-16-01
Prices in pharmacies: from 57 rubles.
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Sulgin Avexima is an antimicrobial agent.
Release form and composition
Dosage form - tablets: flat-cylindrical, white, with a line and a chamfer (in a cardboard box, instructions for use of Sulgin Avexim and 1, 2, 3, 4 or 5 blisters of 10 tablets each, it is also possible to pack in contour non-cell packs of 10 tablets).
Composition of 1 tablet:
- active substance: sulfaguanidine monohydrate - 500 mg;
- auxiliary components: calcium stearate, sodium carboxymethyl starch, potato starch.
Pharmacological properties
Pharmacodynamics
Sulgin Avexima is an antibacterial bacteriostatic drug. The mechanism of its action is explained by the ability to competitively inhibit dihydropteroate synthetase and antagonize para-aminobenzoic acid (PABA), as a result of which the synthesis of tetrahydrofolic acid, which is necessary for the synthesis of pyrimidines and purines, is disrupted. The drug inhibits the growth of Escherichia coli, reduces the synthesis of niacin, riboflavin and thiamine in the intestine.
The bacteriostatic effect of Sulgin Avexim is manifested against such microorganisms as Shigella dysenteriae, Staphylococcus spp., Streptococcus spp., Proteus vulgaris and Escherichia coli.
Pharmacokinetics
After taking the tablet, Sulgin Avexim sulfaguanidine monohydrate is slightly absorbed in the digestive tract, therefore, a high bacteriostatic concentration of the drug is established in the intestine.
Indications for use
Indications for Sulgin Avexim are:
- colitis;
- enterocolitis;
- bacterial dysentery.
Also, the drug is used during the preparation of the patient for surgery on the colon.
Contraindications
- insufficiency of glucose-6-phosphate dehydrogenase;
- B 12 - deficiency anemia;
- porphyria;
- nephrourolithiasis;
- hyperbilirubinemia in children;
- children under 3 years old;
- period of pregnancy and lactation;
- hypersensitivity to any component of Sulgin Avexim tablets or other sulfonamides.
Sulgin Avexima, instructions for use: method and dosage
In the case of acute dysentery in adult patients, the first course is mandatory and, if necessary (after 5-6 days) the second:
- the first course: the first two days - 1000 mg every 4 hours (in total 6000 mg per day), the third and fourth days - 1000 mg every 6 hours (in total 4000 mg per day), the fifth and sixth days - 1000 mg every 8 h (a total of 3000 mg per day);
- the second course: the first two days - 1000 mg every 4 hours, except for 8 hours at night (in total 5000 mg per day), the third and fourth days - 1000 mg every 4 hours, excluding the night (in total 4000 mg per day), the fifth day - 3000 mg per day.
Children over 3 years of age with acute dysentery are prescribed 500 mg 4 times a day for a course of 7 days.
Treating other infections:
- adults: the first day - 1000-2000 mg every 4-6 hours, the next 2-3 days - half the initial dose;
- children from 3 years old: the first day - 100 mg / kg in equal parts during the day with an interval of 4 hours, the following days - 250-500 mg every 6-8 hours.
For the prevention of postoperative complications, patients are prescribed 50 mg / kg every 8 hours for 5 days before surgery and 7 days after it.
The maximum allowable doses for adults: single - 2000 mg, daily - 7000 mg.
Side effects
- allergic reactions: exfoliative dermatitis, urticaria;
- from the gastrointestinal tract: nausea, vomiting;
- from the urinary system: crystalluria;
- others: neuritis, leukopenia, hypovitaminosis B.
Overdose
There have been no reports of overdose cases of Sulgin Avexim.
special instructions
During the period of therapy with an antimicrobial agent, it is advisable to take vitamins of group B.
Insufficient doses of the drug or early withdrawal can contribute to the development of sulfaguanidine-resistant pathogen strains.
In order to avoid the development of crystalluria (a side effect from the urinary system) during the treatment period, patients are recommended to drink plenty of fluids (from 2 to 3 liters per day).
Influence on the ability to drive vehicles and complex mechanisms
No information available.
Application during pregnancy and lactation
The period of pregnancy and lactation is a contraindication to the appointment of Sulgin Avexim.
Pediatric use
The drug is not intended for the treatment of children under 3 years of age. It is contraindicated for the treatment of children with hyperbilirubinemia.
With impaired renal function
Sulgin Avexima, if indicated, is not used in patients with nephrourolithiasis.
Drug interactions
Procaine and benzocaine reduce the antimicrobial effect of sulfaguanidine monohydrate, since they release PABA during hydrolysis.
With the simultaneous use of hexamethylenetetramine and ascorbic acid, the risk of developing crystalluria increases.
Myelotoxic drugs increase the manifestations of hematotoxicity of Sulgin Avexim. Indirect anticoagulants, phenytoin, hypoglycemic agents (sulfonylurea derivatives), nonsteroidal anti-inflammatory drugs increase the manifestations of side reactions of sulfaguanidine monohydrate.
Sulgin Avexima reduces the effectiveness of oral contraceptives.
Analogs
Analogues of Sulgin Avexim are Bactrim, Dvaseptol, Biseptol, Co-trimoxazole, Sulgin, Sulfadimethoxin, Phtalazol, etc.
Terms and conditions of storage
Store at a temperature not exceeding 30 ° C in a dry place out of the reach of children.
Shelf life is 4 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Sulgin Avexima
According to reviews, Sulgin Avexima is an inexpensive but effective antimicrobial agent that helps well with gastrointestinal diseases and effectively eliminates diarrhea.
The price of Sulgin Avexima in pharmacies
The price of Sulgin Avexima 500 mg for a pack of 10 tablets is about 71 rubles, for a pack of 20 pcs. - 93 rubles.
Sulgin Avexima: prices in online pharmacies
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Drug name Price Pharmacy |
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Sulgin Avexima 500mg tablets 10 pcs. RUB 57 Buy |
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Sulgin Avexima tablets 500mg 20 pcs. RUB 95 Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
