Sydnocarb
Sydnokarb: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Drug interactions
- 11. Analogs
- 12. Terms and conditions of storage
- 13. Terms of dispensing from pharmacies
- 14. Reviews
- 15. Price in pharmacies
Latin name: Sydnocarb
ATX code: N06BX24
Active ingredient: mesocarb (Mesocarb)
Producer: Farmakon, JSC (Russia)
Description and photo updated: 2019-27-08
Sydnocarb is a psychostimulating drug.
Release form and composition
It is produced in the form of tablets (10 pieces in a blister strip, 5 packs in a cardboard box and instructions for use of Sidnokarb).
The active ingredient is mesocarb (5 mg, 10 mg or 25 mg in 1 tablet).
Pharmacological properties
Pharmacodynamics
The active ingredient in Sydnocarb, mesocarb, is a psychostimulant substance. In terms of chemical structure, it is similar to phenamine, but in comparison with it it has less toxicity, does not have a pronounced peripheral adrenostimulating activity, it affects noradrenergic structures of the brain more strongly than dopaminergic ones. Stimulates the reuptake of catecholamines and monoamine oxidase activity.
The development of the stimulating effect of mesocarb occurs gradually (there is no sharp initial activating effect). When compared with phenamine, the effect of mesocarb is long and is not accompanied by such effects as euphoria, motor agitation, tachycardia, and a sharp increase in blood pressure. During the aftereffect period, general weakness and drowsiness does not cause. Also, mesocarb has less pronounced addiction phenomena.
Pharmacokinetics
Mesocarb after oral administration is rapidly absorbed from the gastrointestinal tract.
Metabolism occurs by C-hydroxylation of the benzene ring of the phenylcarbamoyl radical and the aliphatic chain of the phenylisopropyl substituent with the formation of the metabolite - α-oxidicarb. At the same time, the stimulating effect decreases, since α-oxidicarb penetrates poorly through the blood-brain barrier.
86% of the dose is excreted within 48 hours. Excretion routes: 60% - with urine; 30% - with feces; 10% - with exhaled air. Does not cumulate.
Indications for use
- sluggish schizophrenia with a predominance of asthenic disorders and the absence of productive symptoms;
- asthenia, accompanied by apathy, increased drowsiness, lethargy and decreased performance;
- drowsiness, hypochondriac syndrome;
- asthenoneurotic syndrome (in post-infectious, post-intoxication and post-traumatic periods);
- stuporous, apatoabulic and substuporous states;
- asthenia caused by taking tranquilizers and neuroleptics;
- artificial exacerbation of schizophrenia (in order to overcome resistance to treatment with psychoactive drugs);
- correction of side effects caused by benzodiazepine anxiolytics;
- withdrawal symptoms, alcoholism and adynamic depression;
- mental retardation in children, spontaneity, weakness, organic diseases of the central nervous system (lethargy, lethargy, asthenic syndrome);
- increased fatigue in mentally healthy people.
Contraindications
- arterial hypertension;
- severe atherosclerosis;
- increased excitability;
- concomitant use of tricyclic antidepressants or monoamine oxidase inhibitors, as well as a period within 2 weeks after their cancellation;
- period of pregnancy;
- increased individual sensitivity to drug components.
Sydnocarb is used with caution during breastfeeding.
Sydnokarb, instructions for use: method and dosage
Sydnocarb tablets are taken orally before meals, in the morning. Frequency rate of application - 1-2 times a day.
The initial dose is 5 mg per day, then it is gradually increased to 15-25-50 mg per day. The maintenance dose of the drug is 5-10 mg per day.
With lucid catatonia, the daily dose of Sydnocarb is from 125 to 150 mg.
For children, debilitated patients and elderly people, the dose of the drug should not exceed 2.5–5 mg per day.
The maximum single dose for adult patients is 75 mg, the daily dose is 150 mg.
If the therapeutic effect is absent within 3-4 days, further use of Sydnocarb is impractical.
Side effects
During the treatment period, the following side effects may occur:
- increased blood pressure;
- decreased appetite;
- insomnia, headache;
- increased anxiety, impatience, incontinence, hallucinations and delirium, irritability;
- extrapyramidal disorders (when used in maximum doses);
- allergic reactions.
Overdose
The main symptoms are: loss of appetite, lethargy, drowsiness, headache, insomnia, increased blood pressure.
It is recommended to stop using the drug and seek immediate medical attention.
special instructions
It is not recommended to take Sydnocarb tablets in the evening.
It is undesirable to use the drug continuously for a long time.
Application during pregnancy and lactation
Sydnocarb is not prescribed during pregnancy.
If it is necessary to take the drug during lactation, therapy requires medical supervision. Avoiding breastfeeding may be required.
Drug interactions
Sydnocarb can be used simultaneously with phenazepam, while the ratio of phenazepam to mesocarb should be as follows: 1: 1.25 or 1: 2.5.
Simultaneous use with monoamine oxidase inhibitors and tricyclic antidepressants is prohibited.
Analogs
Analogs of Sidnokarb are Mesocarb, Phenotropil, Enerion, Sidnogluton, etc.
Terms and conditions of storage
Store in a dry place at room temperature. Keep out of the reach of children.
Shelf life is 2 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Sidnokarb
Reviews about Sidnokarb are few. In most cases, they indicate a high efficiency of the drug.
Price for Sydnocarb in pharmacies
The price of Sydnocarb is unknown, as the drug is not available in pharmacies.
The approximate cost of analogues: Phenotropil tablets 100 mg for 30 pcs. in the package - 1032-1106 rubles; Enerion tablets 200 mg, 20 pcs. in the package - 699–804 rubles.
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
