Lozap
Instructions for use:
- 1. Composition and form of release
- 2. Pharmacological action
- 3. Indications for use
- 4. Contraindications to use
- 5. Application during pregnancy and lactation
- 6. Method of administration and dosage
- 7. Side effects
- 8. Overdose
- 9. Interaction with other medicinal products
- 10. Special instructions for use
- 11. Influence on the ability to drive a car or other mechanisms
- 12. Analogs
Prices in online pharmacies:
from 200 rubles.
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Lozap is a pharmacological drug from the group of angiotensin II receptor antagonists used to treat hypertension.
Composition and form of release
Lozap is available in tablets (dosage 12.5 and 50 mg). The active ingredient is losartan. According to the instructions, Lozap tablets contain the following auxiliary components: microcrystalline cellulose, mannitol, colloidal silicon dioxide, crospovidone, talc, magnesium stearate, hypromellose, macrogol, titanium dioxide.
Lozap tablets are oval, biconvex, film-coated. The drug is produced in blisters of 10 tablets. In a cardboard package there can be 3, 6 or 9 plastic blisters with instructions.
Pharmacological action Lozap
According to the instructions, Lozap refers to specific antagonists of angiotensin II receptors and has an antihypertensive effect. The drug reduces the total peripheral vascular resistance, lowers blood pressure, reduces the load on the heart muscle, reduces the content of adrenaline and aldosterone in the blood, has a diuretic effect. Lozap increases exercise tolerance in patients with signs of chronic heart failure and prevents myocardial hypertrophy.
After a single dose of Lozap, the maximum hypotensive effect develops after 6 hours and gradually decreases within 24 hours. With constant administration of the drug, the maximum hypotensive effect will occur 3-6 weeks after the start of Lozap.
The use of Lozap in patients with arterial hypertension and proteinuria of more than 2 g / day significantly reduces the loss of protein in the urine, the excretion of albumin and immunoglobulins. At a dosage of up to 150 mg per day, Lozap does not affect the level of glucose in the blood (fasting) and lipid profile.
After oral administration, Lozap is well absorbed, metabolized in the liver. The bioavailability of the drug is 33%. The drug and its metabolites are excreted mainly through the intestines and kidneys.
Lozap practically does not penetrate the blood-brain barrier.
Indications for use
Lozap is used to treat hypertension. Also, the drug is indicated as part of a complex treatment in patients with chronic heart failure, with diabetic nephropathy (with hypercreatininemia and proteinuria). According to the instructions, Lozap can be used to reduce the risk of developing cardiovascular complications in patients with essential hypertension and left ventricular hypertrophy.
Contraindications to the use of Lozap
Lozapa is contraindicated in such cases:
- hypersensitivity to losartan and other components of the drug;
- age up to 18 years (clinical studies on the safety of use in this group have not been performed);
- pregnancy and lactation.
With caution, Lozap is used for violations of water and electrolyte metabolism, with bilateral stenosis of the renal arteries, or stenosis of the renal artery of a single kidney, as well as with signs of renal or hepatic failure.
Application during pregnancy and lactation
Clinical studies on the use of Lozap during pregnancy have not been conducted. It should be noted that it is a known fact that drugs that act on the angiotensin-aldosterone system have a teratogenic effect (cause malformations and even fetal death). If pregnancy occurs while using Lozap, then it should be canceled immediately. During lactation, the drug is also not recommended for use.
Dosing and Administration Lozap
This drug is taken orally once a day, there is no dependence of the time of intake on food consumption.
In the treatment of arterial hypertension, the average dose of Lozap is 50 mg. If necessary, the dose can be increased to 100 mg.
With chronic heart failure, it is recommended to take Lozap at 12.5 mg per day. The dose can be increased (at weekly intervals) if the drug is well tolerated.
If a patient with heart failure receives large doses of diuretics (diuretics), then the Lozap dose is reduced to 25 mg per day.
Patients with impaired renal and hepatic function, as well as elderly patients, are recommended a lower initial dose of this drug (25 mg per day).
Side effect
According to reviews, Lozap rarely causes side effects. If a side effect occurs, then this condition is usually transient and drug withdrawal is not required. The most common side effect of Lozap in the treatment of hypertension is dizziness (4.1%). Orthostatic action of Lozap, according to reviews, was noted in less than 1% of patients.
The other side effects of Lozap are practically the same as the side effects when taking a placebo ("dummy"), so their connection with taking this drug is questionable. These side effects include asthenia, fatigue, chest pain, swelling of the extremities, palpitations, diarrhea, abdominal pain, nausea, back and / or leg pain, calf muscle cramps, headache, insomnia, cough, nasal congestion …
Lozap overdose
In case of an overdose of this drug, there may be a pronounced decrease in blood pressure, tachycardia (less often bradycardia). Treatment consists in the appointment of symptomatic treatment, the use of forced diuresis. Hemodialysis with Lozapom overdose is not effective.
Interaction with other medicinal products
According to the instructions, Lozap can be combined with other antihypertensive drugs, it mutually enhances the effect of sympatholytics and beta-adrenal locators.
With the combined use of Lozap and diuretics, an increase in the action of both drugs is noted.
When taken simultaneously with digoxin, hydrochlorothiazide, warfarin, cimetidine, phenobarbital, erythromycin and ketoconazole, no pharmacological interaction was found. According to reviews, Lozap goes well with these drugs, without causing any symptoms.
The use of Lozap together with potassium-sparing diuretics (spironolactone, amiloride, triamterene) increases the risk of hyperkalemia.
Special instructions for the use of Lozap
It is necessary to start using this drug in a lower dose, it is also necessary to correct the water-electrolyte balance before prescribing Lozap.
In patients with cirrhosis of the liver, the concentration of this drug in the blood increases, so you need to use it in lower doses.
It is recommended to control the concentration of potassium in the blood in elderly patients and with impaired renal function during therapy with Lozapom.
Impact on the ability to drive a car or other mechanisms
According to the instructions, Lozap does not affect the ability to drive a car and the ability to concentrate when working with moving machinery.
Lozap's analogs
Analogues of Lozap are drugs from the same group of angiotensin II receptor antagonists, these include: Lorista, Vasotens, Losartan, Presartan, Kozaar, Bloktran, Renikard, Brozaar, Lozarel, Lotor.
Before replacing Lozap with an analogue, you should consult your doctor. These drugs are not intended for self-administration.
Lozap: prices in online pharmacies
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Drug name Price Pharmacy |
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Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
