Seroquel
Instructions for use:
- 1. Release form and composition
- 2. Indications for use
- 3. Contraindications
- 4. Method of application and dosage
- 5. Side effects
- 6. Special instructions
- 7. Drug interactions
- 8. Terms and conditions of storage
Prices in online pharmacies:
from 904 rub.
Buy
Seroquel is an antipsychotic (neuroleptic) drug.
Release form and composition
Seroquel comes in the following forms:
- film-coated tablets, 25 mg: biconvex, round, pink, engraving "SEROQUEL 25" is visible on one side (in blisters of 10 pieces, six blisters in a cardboard box);
- film-coated tablets, 100 mg: biconvex, round, yellow, engraving "SEROQUEL 100" is visible on one side (in blisters of 10 pieces, six blisters in a cardboard box);
- film-coated tablets, 200 mg: biconvex, round, white, engraving "SEROQUEL 200" is visible on one side (in blisters of 10 pieces, six blisters in a cardboard box).
The drug is also available in packages consisting of a set of tablets with different doses of the active substance: in blisters of 10 pieces, in a cardboard box one blister (6 pink tablets, 3 yellow tablets and 1 white tablet).
Composition for one tablet:
- active substance: quetiapine - 25, 100 or 200 mg;
- auxiliary components: povidone, calcium hydrogen phosphate, microcrystalline cellulose, sodium carboxymethyl starch, lactose monohydrate, magnesium stearate;
- film shell: titanium dioxide, macrogol 400, iron dye red oxide (pink tablets), hypromellose, iron oxide yellow dye (pink and yellow tablets).
Indications for use
Seroquel is used to treat acute and chronic psychoses (including schizophrenia), as well as manic and depressive conditions.
Contraindications
Absolute:
- children and adolescents under 18 years of age (since the safety and efficacy of quetiapine in this age group have not been studied);
- hypersensitivity to quetiapine and / or auxiliary components of the drug.
Relative (quetiapine is used with caution):
- impaired renal and / or liver function;
- cardiovascular diseases;
- cerebrovascular diseases;
- conditions associated with the risk of high blood pressure;
- seizures (history);
- elderly age;
- simultaneous use with drugs that prolong the QT interval c;
- simultaneous use with clarithromycin, erythromycin, antifungal agents from the azole group, protease inhibitors and nefazodone;
- simultaneous use with alcohol and drugs that depress the central nervous system.
Method of administration and dosage
Seroquel is taken orally twice a day. Taking the drug does not depend on food intake.
Recommended doses and treatment regimens:
- acute and chronic psychoses, including schizophrenia: on the first day - 50 mg, on the second - 100 mg, on the third - 200 mg, on the fourth - 300 mg. In the future, the daily dose can vary in the range of 150-750 mg, depending on the individual tolerance of the drug and the effect obtained. The maximum dose is 750 mg per day;
- manic states: on the first day - 100 mg, on the second - 200 mg, on the third - 300 mg, on the fourth - 400 mg. By the sixth day, the dose can be increased to 800 mg per day. The dose should be increased gradually, by no more than 200 mg per day. In the future, the daily dose may vary in the range of 200-800 mg, depending on the individual tolerance of the drug and the effect obtained. Typically, an effective dose of quetiapine is 400–800 mg per day. The maximum dose is 800 mg per day;
- depressive conditions: 300 mg once a day (at night). On the first day, the daily dose is 50 mg, on the second - 100 mg, on the third - 200 mg, on the fourth - 300 mg. The maximum daily dose is 600 mg (no clinical improvement was noted with an increase).
For elderly patients, quetiapine is prescribed at an initial dose of 25 mg per day. Then the dose should be gradually increased (by 25–50 mg per day) until the effective dose is reached. Most likely, it will be less than a similar dose for young patients.
In hepatic or renal failure, treatment begins with a dose of 25 mg per day. Then the dose should be increased daily by 25-50 mg until the effective dose is reached.
Side effects
- digestive system: dyspepsia, dry mouth, diarrhea or constipation, abdominal pain, transient increase in the activity of liver enzymes;
- respiratory system: rhinitis;
- cardiovascular system: increased blood pressure, tachycardia, orthostatic hypotension;
- hematopoietic system: neutropenia and / or asymptomatic leukopenia, eosinophilia (rarely);
- central nervous system and sensory organs: anxiety, headache, dizziness, drowsiness, neuroleptic malignant syndrome (rare), ear pain;
- genitourinary system: urinary tract infections;
- musculoskeletal system: muscle pain;
- endocrine system: a slight decrease in the level of thyroid hormones (reversible, dose-dependent);
- metabolism: a slight increase in the level of triglycerides and cholesterol in the blood;
- dermatological reactions: dry skin, rash;
- other reactions: fever, back pain and chest pain, asthenia, weight gain.
special instructions
Cancellation of the drug Seroquel, especially when used in high doses, is carried out gradually. Otherwise, a withdrawal syndrome may occur, which is manifested by the following symptoms: insomnia, nausea, vomiting, akathisia, dyskinesia, dystonia, exacerbation of psychotic disorders.
If signs of neuroleptic malignant syndrome appear, quetiapine should be discontinued and appropriate treatment should be carried out.
During pregnancy and lactation, the use of the drug is possible only if the expected benefit to the mother is higher than the potential risk to the fetus or child. When prescribing quetiapine to a nursing woman, breastfeeding should be discontinued.
One of the side effects of quetiapine is drowsiness, therefore, during the period of drug treatment, it is advisable to refuse to perform work associated with the need for a high speed of reactions and concentration.
Drug interactions
Erythromycin and ketoconazole can theoretically increase the plasma concentration of quetiapine, increasing the likelihood of side effects.
With the simultaneous use of quetiapine with barbiturates, phenytoin, rifampicin and carbamazepine, the concentration of quetiapine in the blood plasma decreases.
When taken together with thioridazine, the clearance of quetiapine may increase.
Terms and conditions of storage
Store at a temperature not exceeding 30 ° C out of reach of children.
The shelf life is 3 years.
Seroquel: prices in online pharmacies
|
Drug name Price Pharmacy |
|
Seroquel 25 mg film-coated tablets 60 pcs. 904 RUB Buy |
|
Seroquel 100 mg film-coated tablets 60 pcs. 1155 RUB Buy |
|
Seroquel Prolong 200 mg film-coated tablets of prolonged action 60 pcs. 1799 RUB Buy |
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Seroquel 200 mg film-coated tablets 60 pcs. 1868 RUB Buy |
|
Seroquel Prolong 300 mg film-coated prolonged-release tablets 60 pcs. RUB 3799 Buy |
|
Seroquel Prolong 400 mg film-coated tablets of prolonged action 60 pcs. RUB 5481 Buy |
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
