Sodium Oxybutyrate

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Sodium oxybutyrate: instructions for use and reviews

1. Release form and composition
2. Pharmacological properties
3. Indications for use
4. Contraindications
5. Method of application and dosage
6. Side effects
7. Overdose
8. Special instructions
9. Drug interactions
10. Application during pregnancy and lactation
11. Analogs
12. Terms and conditions of storage
13. Terms of dispensing from pharmacies
14. Reviews
15. Price in pharmacies

Latin name: Sodium oxybutirate

ATX code: N01AX11

Active ingredient: Sodium oxybutirate (Sodium oxybutirate)

Producer: "PHARMAK" OJSC (Ukraine)

Description and photo update: 2019-12-08

Sodium oxybutyrate is a drug that has anesthetic, hypnotic, sedative, muscle relaxant effect.

Release form and composition

It is produced in the form of an injection solution (in ampoules of 10 ml, in a cardboard box of 10 ampoules, complete with an ampoule knife).

Active ingredient: sodium oxybate, in 1 ml - 200 mg.

Pharmacological properties

Pharmacodynamics

Sodium oxybate - the active component of Sodium oxybutyrate - interacts with various receptors, affecting the functions of calcium, potassium and other channels. As a result, the release of activating mediators from the presynaptic endings is inhibited and postsynaptic inhibition occurs. Sodium oxybutyrate has a depressing effect on the central nervous system.

When taking small doses of the drug, an anxiolytic effect is observed, the severity of neurotic disorders and some autonomic reactions to stressful situations decreases. The drug also has a hypnotic effect.

Large doses of Sodium oxybutyrate are used for muscle relaxation and general anesthesia. It is also characterized by sedative, anticonvulsant and anti-shock effects. During treatment with the drug, manifestations of nootropic activity are possible.

During therapy, the overall resistance of the body - the brain, cardiovascular system and other organs - to hypoxia increases. Also, there is an improvement in microcirculation, increased glomerular filtration and normalization of renal function with blood loss.

Pharmacokinetics

When administered intravenously, up to 70% of the dose entered into the body is removed from the blood plasma within 2-3 hours. Sodium oxybate crosses the blood-brain barrier at a low rate. The onset of the surgical stage of anesthesia is recorded 30-40 minutes after administration. The duration of anesthesia when using sodium hydroxybutyrate is 2-4 hours.

Indications for use

Sleep disturbances;
Neurotic disorders;
Glaucoma;
Severe hypoxic conditions;
Postoperative psychoses;
Glaucoma.

In surgical practice, Sodium oxybutyrate is used for induction of anesthesia during incomplete operations while maintaining spontaneous breathing.

Contraindications

Hypokalemia;
Myasthenia gravis;
Severe toxicosis during pregnancy, accompanied by hypokalemia and hypertensive syndrome.

Instructions for the use of Sodium oxybutyrate: method and dosage

The drug is administered intravenously at a rate of 1-2 ml per minute, in a 5-40% glucose solution.

The dose is 0.05-0.12 g per kilogram of body weight.

Side effects

With the rapid introduction of sodium oxybutyrate, the following are possible: respiratory failure, drowsiness, nausea, vomiting, psychomotor agitation, hypokalemia.

Overdose

An overdose is manifested by symptoms such as agitation, limb cramps and respiratory arrest. In this case, symptomatic treatment is prescribed.

special instructions

In case of an overdose, there may be twitching of the limbs and agitation, in severe cases, respiratory arrest is possible.

Drug interactions

Sodium oxybutyrate enhances the effect of anesthetics and analgesics.

With outpatient use of the drug, caution should be exercised by people driving vehicles, as well as those employed in industries that require speed of reactions and concentration of attention.

Application during pregnancy and lactation

According to the instructions, Sodium oxybutyrate is prohibited for use in severe pregnancy toxicosis.

Analogs

Analogues of Sodium oxybutyrate are: Sodium Oxybate, Ketamine, Thiopental sodium, Droperidol, Sombrevin.

Terms and conditions of storage

Store in a dark place out of reach of children.

The shelf life is 4.5 years.

Terms of dispensing from pharmacies

Dispensed by prescription.

Reviews about Sodium oxybutyrate

Numerous reviews of Sodium oxybutyrate are found in many medical forums. However, most of them are associated not with its effectiveness and use for medical purposes, but with the use of the drug as a replacement for alcoholic beverages, which allows people to relax and forget about problems. But at the same time, they quickly get used to this remedy, and the consequences may be even worse than with the formation of alcohol dependence.

Also, many people are interested in the peculiarities of introducing Sodium oxybutyrate at home, various therapy regimens in certain cases, and also where the drug can be bought.

Price for Sodium oxybutyrate in pharmacies

At the moment, the price of Sodium oxybutyrate is unknown, since it has been discontinued and is not used in medical practice.

Maria Kulkes Medical journalist About the author

Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!