Xidiphon
Ksidifon: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacodynamics and pharmacokinetics
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Drug interactions
- 10. Analogs
- 11. Terms and conditions of storage
- 12. Terms of dispensing from pharmacies
- 13. Reviews
- 14. Price in pharmacies
Latin name: Xydifon
ATX code: M05BA01
Active ingredient: Etidronic acid (Etidronic acid)
Manufacturer: JSC Moskhimfarmpreparaty them. N. A. Semashko (Russia)
Description and photo update: 2019-20-09
Ksidiphon is a drug that regulates phosphorus-calcium metabolism in the body.
Release form and composition
Dosage form - 20% solution for preparation of 2% solution for oral administration: colorless and odorless (in bottles of 50 or 100 ml, in polyethylene containers of 100 and 250 ml).
10 ml of solution contains:
- Active ingredient: etidronic acid (potassium hydroxyethylidene diphosphonate dihydrate) - 2 g;
- Auxiliary components: sodium hydroxide, purified water.
Pharmacodynamics and pharmacokinetics
Ksidiphon is used to correct the metabolism of bone and cartilage tissue by normalizing calcium metabolism. Etidronic acid - the active substance of the drug - prevents calcium loss from bone tissue, providing prevention of osteoporosis and pathological calcification of various soft tissues.
Etidronic acid prevents the crystallization of calcium salts, preventing the appearance of stones (insoluble calcium salts with mucopolysaccharides, oxalates, phosphates). In patients with nephritis, the active component of the drug has a moderately pronounced anti-inflammatory effect.
The drug increases the rate of excretion of heavy metals from the body: magnesium, lead, strontium, as well as tin, antimony, silicon. At the same time, the balance of trace elements is not disturbed. Ksidiphon improves the biophysical state of the cell membranes of the immune system and is used in the treatment of bronchial asthma.
After oral administration, the drug is absorbed in the gastrointestinal tract for 30 minutes, but is not metabolized in the body. Etidronic acid is excreted unchanged through the kidneys. The half-life is 1 day.
Indications for use
According to the instructions, Ksidifon, as a means of regulating calcium metabolism in children and adults, is prescribed for the following conditions / diseases:
- Urolithiasis and other kidney diseases;
- Hypervitaminosis D;
- Osteoporosis (for treatment and prevention);
- Hyperparathyroidism (fibrocystic osteitis) and concomitant interstitial nephritis;
- Rheumatoid arthritis (to prevent the development of osteoporosis and osteopenia with prolonged immobilization, an increase in bone mass in secondary osteoporosis).
Also, the drug is prescribed if the following indications are present:
- Acceleration of the elimination of excess heavy metals from the body: antimony, tin, lead, strontium, silicon;
- Stabilization of membranes of immunocompetent cells in adults with mild and moderate bronchial asthma (along with other drugs);
- Prevention of osteoporosis in adults with hormone-dependent bronchial asthma (along with other drugs).
Contraindications
- Hypocalcemia;
- Pregnancy and the period of breastfeeding;
- Hypersensitivity to drug components.
In chronic enterocolitis, Ksidifon is prescribed with caution.
Instructions for the use of Ksidifon: method and dosage
The solution should be taken orally, preferably 30 minutes before meals.
Before use, 9 parts of water (distilled or boiled) must be added to 1 part of the base 20% solution. After dilution, the solution must be stored in the refrigerator.
Recommended dosing regimen (single dose):
- Adults and children over 10 years old: 300 mg (1 tablespoon);
- Children 3-10 years old: 200 mg (1 dessert spoon);
- Children under 3 years of age: 10 mg / kg body weight (1 teaspoon).
Frequency rate of admission - 2-3 times a day.
The duration of the primary treatment course is 14 days. With crystalluria and calculi in the kidneys, 5-6 courses are indicated at intervals of 21 days for 1-2 years. For the prevention of recurrence of stone formation, Ksidiphon is prescribed in a course of 2 to 6 months.
In osteoporosis (treatment and prevention), the drug is prescribed at 5-7 mg / kg for 2-3 months. The courses are repeated with a break of 1-2 months.
With trabecular osteoporosis and osteopenia against the background of rheumatoid arthritis, Xidiphon should be taken for at least a year. The daily dose is 5-10 mg / kg of body weight (in 2 divided doses). At the same time, it is recommended to eat foods rich in calcium salts (corresponds to 500 ml of milk), or, if it is impossible for any reason to comply with this condition, take 1500 mg of calcium gluconate per day.
For chronic intoxication with heavy metals and patients living in environmentally unfavorable conditions for heavy metals, the drug is recommended to be taken from 7 to 10 days of each month at a daily dose of 10 mg / kg of body weight.
In case of bronchial asthma, Ksidifon is prescribed simultaneously with other drugs for the treatment of patients over 16 years of age, the duration of therapy is no more than 30 days.
Side effects
- Metabolism: rickets-like effect and hypomagnesemia with a prolonged course of taking the solution in high doses (for prophylactic purposes, it is recommended to use drugs containing magnesium in minimal doses and periodically take therapeutic doses of vitamin D);
- Digestive system: in some cases, a laxative effect may be observed (the daily dose can be divided into more doses than recommended in the instructions);
- Others: change in lipid peroxidation (takes place while taking with vitamin E: once a day in a single dose of 3-5 drops of a 5% oil solution).
Overdose
If you accidentally take high doses of Xidiphon, it is possible to increase the side effects described in the instructions.
special instructions
With reduced renal function, the dosage regimen of Xidiphon needs to be adjusted.
During therapy, it is necessary to receive sufficient amounts of calcium and vitamin D.
Drug interactions
No information on interactions with other drugs is provided.
Analogs
Analogs of Ksidifon are: Phosphotech, Etidronic acid.
Terms and conditions of storage
Store in a dark place, out of reach of children, at temperatures up to 25 ° C.
The shelf life is 3 years.
The prepared solution can be taken within 1 month, provided it is stored in the refrigerator.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Xidiphon
In most cases, reviews about Xidiphon are positive. Patients talk about its high efficiency in the treatment of salt deposits in the joints, urolithiasis, osteoporosis, and bone fractures.
Some patients buy Xenia cream with xidiphon in pharmacies. It is successfully used in the treatment of osteochondrosis, radiculitis, rheumatism, arthritis, osteoporosis and for the prevention of salt deposits in the joints.
Price for Xidiphon in pharmacies
Previously, the price for a bottle of Ksidifon 20% (volume 50 ml) in the network of pharmacies was about 387 rubles, but at the moment the drug is not on sale.
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
