Kontrikal - Instructions, Application, Analogues

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Contrikal

Instructions for use:

1. Pharmacological action
2. Release form
3. Indications for use
4. Contraindications
5. Instructions for use
6. Side effects

Contrikal is a drug for the treatment of acute pancreatitis.

pharmachologic effect

The active substance of Contrikal is aprotinin, which tends to inhibit proteolytic enzymes.

Also, aprotinin inhibits the kallikrein-kinin system, so it can be used for various shocks.

The drug inactivates proteinases and plasmin, which makes it possible to use it in acute pancreatitis or coagulopathies.

The drug is metabolized in the kidneys, excreted in the urine for two days.

Release form

Produce Contrikal in powder for diluting the solution for intravenous administration of the drug. You can buy Contrikal with a solvent, in a pack of 10 ampoules.

Kontrikal's analogs - Gordox, Aprotex, Aprotinin, Ingiprol, Vero-narkap, Trasilol500,000, Ingitril, Traskolan, Aerus.

Indications for use Kontrikal

According to the instructions, Contrikal is prescribed for the treatment of acute forms of pancreatitis (including pancreatic necrosis), for the prevention of pancreatitis after operations, fat embolism after fractures and operations.

Good reviews about Kontrikal, used in the complex therapy of toxic, burns, hemorrhagic, traumatic shock.

Also, the use of Kontrikal is effective in bleeding due to coagulopathies (blood clotting disorders), provoked by hyperfibrinolysis.

Contraindications

According to the instructions, Kontrikal should not be used in case of hypersensitivity to the active substance, during pregnancy (up to 12 weeks). Caution should be observed when using Contrikal in patients with polyvalent allergies.

After 12 weeks. pregnancy, the drug can be used only for special indications.

You can not take Contrikal at the same time as urokinase, streptokinase, it can inhibit their action. Also, the agent is not compatible with antibiotics and solutions containing lipids, amino acids, dextran.

You can buy Kontrikal only with a prescription.

If it becomes necessary to use analogs of Contrikal, you should read their instructions, because side effects and contraindications may vary.

Instructions for use Kontrikal

You can buy Contrikal in ampoules of 10,000, 30,000, 50,000ED.

For the treatment of acute pancreatitis, the agent is administered intravenously and as early as possible, at a dosage of 200,000 - 300,000 IU. After that, for 24 hours. the same dose of the drug is injected intravenously. Treatment usually lasts until the onset of improvement in the patient's condition and a positive change in these tests.

For the prevention of postoperative pancreatitis, an initial dose of 200,000 IU is prescribed, after which 100,000 IU is administered four times per day every 6 hours.

To eliminate the shock, Contrikal is started to be administered at a dose of 200,000 IU per day, and after every 4 hours. - 140,000U.

To prevent fat embolism, the use of Contrikal begins with a dose of 200,000 IU, which is administered intravenously at a low speed. After that, 200,000 IU per day are injected intravenously.

For the treatment of coagulopathy, Kontrikal, according to the instructions, is prescribed to be administered in a dose of 300,000 IU at a low speed intravenously, then every 4 hours. - intravenous drip, 140,000 IU.

Positive feedback on Kontrikal used to stop labor bleeding. Prescribe for the beginning 700 000 - 1 000 000 IU intravenously and then 700 000 IU every hour until the bleeding is eliminated.

The drug is prescribed for children at the rate of 14,000 IU per 1 kilogram of the child's weight. The drug is administered to children by intravenous stream or drip (at low speed, no more than 5 ml / min), in the supine position. Before use, Kontrikal is diluted with 0.9% sodium chloride solution. The solution is injected immediately, it cannot be stored.

Side effects

The remedy can lead to allergic reactions, increased heart rate, sweating, weakness, shortness of breath, nausea, blue skin.

There are reviews about Kontrikal, that there is a high risk of side effects after repeated administration of the drug, but they can occur after the first administration.

In case of side effects, it is necessary to cancel the drug and use analogs of Contrikal.

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!