Kondronova
Kondronova: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Kondronova
ATX code: M09AX
Active ingredient: glucosamine + chondroitin sulfate (glucosamine + chondroitin sulfate)
Manufacturer: Panacea Biotec (India)
Description and photo updated: 20.11.2018
Prices in pharmacies: from 279 rubles.
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KONDRONOVA is a combined chondrostimulating drug that regulates the exchange of cartilage tissue.
Release form and composition
Capsules: size No. 0, hard, gelatinous, blue; content - white granular powder (10 pcs. in blisters, 3 or 6 blisters in a cardboard box).
Composition of 1 capsule:
- active substances: glucosamine sulfate - 250 mg; chondroitin sulfate - 200 mg;
- additional components: magnesium stearate, croscarmellose sodium, mannitol, purified talc;
- capsule shell: sodium lauryl sulfate, bronopol, gelatin, purified water, titanium dioxide, povidone, quinoline yellow and brilliant blue dyes.
Ointment: light brown (10, 30 or 50 g in tubes; 1 tube in a cardboard box).
Composition of 1 g of ointment:
- active substances: glucosamine sulfate - 25 mg, chondroitin sulfate - 50 mg;
- additional components: mineral oil, white beeswax, white soft paraffin, lanolin (anhydrous), hydroxytoluene butylate, propylparaben, methylparaben.
Pharmacological properties
Pharmacodynamics
The active substances of the Kondronova preparation take part in the biosynthesis of the connective tissue, thereby preventing the processes of cartilage destruction and stimulating tissue regeneration. In addition, the drug has anesthetic and anti-inflammatory effects.
Chondroitin sulfate and glucosamine sulfate are amino saccharides that are the structural basis of articular cartilage and intervertebral disc cartilage. Namely, glycosaminoglycans (mucopolysaccharides) of the intercellular matrix of cartilage, providing elasticity and sliding of the articular surfaces, as well as carbohydrate groups of collagen fibers of cartilage tissue: type II (fibrillar), VI type (microfibrillar), IX type (main) and XI type (assembly), providing strength and elasticity of the cartilage.
Glucosamine sulfate is one of the components of the synthesis of hyaluronic acid, which is involved in the formation of proteoglycans of the structural matrix of joints. This substance provides nonspecific protection of cartilage from chemical damage. In the form of sulfate, glucosamine can serve as a precursor of hexosamine for articular cartilage, and sulfate ion is required for the synthesis of glycosaminoglycans, which are esters of sulfuric acid. Glucosamine protects damaged cartilage from metabolic destruction due to the use of glucocorticosteroids (GCS) or non-steroidal anti-inflammatory drugs (NSAIDs). When taken orally, the drug stimulates the production of cartilage matrix and has a moderate anti-inflammatory effect.
Chondroitin sulfate serves as an additional substrate for the formation of a healthy cartilage matrix. The substance itself and its derivatives stimulate the synthesis of type II collagen and proteoglycans, as well as promote the formation of hyaluronan and protect it from enzymatic breakdown and the damaging effect of free radicals. Also, chondroitin sulfate inhibits the activity of enzymes that break down cartilage (elastase, hyaluronidase), stimulates cartilage repair mechanisms and maintains the viscosity of the synovial fluid. In the treatment of osteoarthritis, the drug relieves negative symptoms and reduces the need for NSAIDs.
Pharmacokinetics
The oral bioavailability of glucosamine sulfate due to the effect of the first passage through the liver is 25%. After oral administration, radioactively labeled glucosamine is found first in plasma components and later penetrates into tissues. The highest concentrations were found in the articular cartilage, kidneys and liver. About 30% of the received dose persists for a long time in the tissues of bones and muscles.
Most of the glucosamine found in feces is the unabsorbed fraction. The fraction of glucosamine that does not bind to plasma proteins or is not metabolized is excreted mainly in the urine. The terminal half-life of glucosamine sulfate bound to plasma proteins is 68 hours.
After ingestion of chondroitin sulfate in a dose of 0.8 g once (or 0.4 g twice a day), the concentration of the substance in the plasma increases sharply within 24 hours. The absolute bioavailability of the drug is about 12%. Low molecular weight chondroitin sulfate is metabolized by desulfurization. It is excreted in the urine. The half-life is 310 minutes.
Indications for use
Kondronov capsules are used for the treatment of osteoarthritis of the peripheral joints and joints of the spine of I-III degree.
In the form of an ointment, the drug is recommended for use in the following cases:
- osteoarthritis of the I – III degree;
- deforming osteoarthritis;
- osteoarthritis;
- gonarthrosis;
- spondylosis;
- primary and secondary arthrosis;
- scapular-humeral periarthritis;
- chondromalacia of the patella;
- intervertebral osteochondrosis.
Contraindications
- bronchial asthma;
- diabetes;
- thrombophlebitis;
- bleeding tendency;
- period of pregnancy and lactation;
- childhood;
- hypersensitivity to drug components.
Instructions for the use of Kondronova: method and dosage
Kondronov capsules are taken orally. Recommended dosage: 2 pcs. 2 or 3 times a day for 2-3 months. After 60 days of therapy, the dose is gradually reduced depending on the individual needs of the patient. If necessary, a second course is carried out on the recommendation of a doctor.
The ointment is applied externally. Apply to intact skin over the affected area and rub in for 2-3 minutes. The course of treatment, depending on the indications and the severity of the disease, lasts from 2 weeks to 4 months.
Side effects
When Kondronova is used in capsule forms, mild gastrointestinal disorders (epigastric pain, constipation or diarrhea, flatulence), dizziness, headache, drowsiness or insomnia, tachycardia, allergic skin reactions, leg pain and peripheral edema are most often possible. In rare cases, there is an exacerbation of bronchial asthma and the development of more serious allergic reactions.
In the form of Kondronova ointment, it is mostly well tolerated, in some cases allergic reactions occur.
Overdose
Overdose cases have not been reported. If the dose of the drug in oral dosage form is significantly exceeded, gastric lavage and symptomatic therapy are recommended to eliminate the violations that have arisen.
When extremely high doses of glucosamine are taken orally (many times the recommended daily dose), hemorrhagic rashes, nausea or diarrhea may occur.
special instructions
In patients with seafood intolerance, when taking Kondronova, the risk of developing allergic reactions increases.
Application during pregnancy and lactation
Kondronova is contraindicated during pregnancy and lactation.
Pediatric use
Kondronova is contraindicated for use in pediatrics.
Drug interactions
According to the instructions, Kondronova reduces the effect of semi-synthetic penicillins, increases the absorption of tetracyclines, and can enhance the effects of antiplatelet agents and anticoagulants.
The drug is compatible with glucocorticosteroids, pain relievers and non-steroidal anti-inflammatory drugs.
Analogs
Analogs of Kondronova are: Artra, Structum, Artravir-complex-INCAMFARM, Tazan, Chondrogluxid, Teraflex, Hondroflex, etc.
Terms and conditions of storage
Shelf life is 2 years.
Keep out of the reach of children. Store at temperatures up to 30 ° C in a dark and dry place.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Kondronov
There are few reviews about Kondronov on specialized medical forums, but they are also contradictory. There are positive ones in which patients confirm the effectiveness of the drug, referring to the fact that it helped to stop pain, removed stiffness and crunch in the joints. Along with that, there are many reviews in which patients complain about the uselessness of this remedy, explaining the low effectiveness of the drug with a low dosage of active ingredients in its composition (250 mg + 200 mg in 1 capsule). Some are alarmed by a little-known manufacturer. In this regard, many patients prefer the more expensive analogs of KONDRONova, containing 500 mg of active substances, from well-known pharmacological companies, which have already proven themselves on the positive side.
As for doctors, their opinions on the chondroprotective effect of such drugs are also ambiguous. The fact is that only a part of chondroprotectors gets into the joint tissues, and to maintain the required therapeutic concentration in the joint fluid, daily doses of glucosamine sulfate and chondroitin sulfate should be at least 1000 and 800 mg, respectively. More and more researchers claim that chondroprotectors do not so much stimulate the synthesis of the cartilage matrix, but rather have an anti-inflammatory effect with prolonged use. Therefore, many experts are convinced that these funds are effective only in the initial stages of the disease and should be used for long-term therapy.
Price for Kondronova in pharmacies
The price of Kondronova in the form of capsules is approximately 400–530 rubles for a pack of 30 pcs., In the form of an ointment - 260–300 rubles per 1 tube.
Kondronova: prices in online pharmacies
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Drug name Price Pharmacy |
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Kondronova capsules 30 pcs. 279 r Buy |
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Kondronova capsules 30 pcs. 411 r Buy |
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Kondronova capsules 120 pcs. 1199 RUB Buy |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
