Comfoderm K
Latin name: Komfoderm K
ATX code: D07AA01
Active ingredient: methylprednisolone aceponate
Producer: Chemical-Pharmaceutical Plant AKRIKHIN, JSC (Russia)
Description and photo updated: 2018-11-07
Prices in pharmacies: from 334 rubles.
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Comfoderm K is an external preparation with keratolytic and anti-inflammatory effects.
Release form and composition
Dosage form Comfoderma K - cream for external use 0.1%: almost white or white, has a weak specific smell (in a cardboard box 1 aluminum tube of 15 or 30 g).
Composition of 100 mg cream:
- active substance: methylprednisolone aceponate - 0.1 mg (in terms of 100% substance);
- auxiliary components: macrogol stearate 40 - 1.5 mg; glyceryl monostearate - 8.5 mg; potassium dihydrogen phosphate - 0.49 mg; ceramides - 0.5 mg; preservative Euxyl PE 9010 (ethylhexylglycerol - 10%, phenoxyethanol - 90%) - 0.9 mg (in terms of phenoxyethanol); sodium hydrogen phosphate dodecahydrate - 0.01 mg; isopropyl myristate - 7 mg; edetate disodium - 0.1 mg; octyldodecanol - 7 mg; hexyldecyl stearate - 7 mg; dimethicone 100 cst - 1 mg; cetostearyl alcohol (stearyl alcohol - 40%, cetyl alcohol - 60%) - 2 mg; propylene glycol - 7 mg; purified water - up to 100 mg.
Pharmacological properties
Pharmacodynamics
Methylprednisolone aceponate, the active ingredient in Comfoderm K, is a non-halogenated synthetic steroid.
When applied externally, the drug suppresses allergic / inflammatory reactions of the skin, as well as reactions associated with increased proliferation. This leads to a decrease in the manifestation of objective symptoms of inflammation (in the form of erythema, edema) and subjective sensations (in the form of itching, irritation, pain, etc.).
The systemic effect of the active ingredient in cases of use in the recommended dose is minimal. After repeated application of the cream to large areas of the skin (40-60% of the entire surface), as well as when applied under an occlusive dressing, adrenal dysfunction is not observed.
As a result of the use of the drug, the substance binds (especially its main metabolite - 6α-methylprednisolone-17-propionate) with intracellular glucocorticoid receptors, after which the steroid-receptor complex binds to some DNA regions of the immune response cells, which leads to a series of biological effects. In particular, there is an induction of the synthesis of macrocortin, which inhibits the release of arachidonic acid. This leads to the formation of inflammatory mediators such as leukotrienes and prostaglandins.
Potentiation of the vasoconstrictor effect of adrenaline and inhibition of the synthesis of vasodilating prostaglandins by glucocorticosteroids leads to the development of a vasoconstrictor action.
Pharmacokinetics
When applied externally, methylprednisolone aceponate is hydrolyzed in the dermis and epidermis.
6α-methylprednisolone-17-propionate is the main and most active metabolite, which has a significantly higher affinity for glucocorticosteroid receptors in the skin.
The degree of absorption of the substance through the skin depends on its condition and the method of application of Comfoderm K (with / without the use of an occlusive dressing). In atopic dermatitis (neurodermatitis) and psoriasis, it is no more than 2.5%, which is only slightly higher than in healthy volunteers (0.5-1.5%).
6α-methylprednisolone-17-propionate, after entering the systemic circulation, rapidly conjugates with glucuronic acid and is inactivated in the form of 6α-methylprednisolone-17-propionate glucuronide.
Substance metabolites are eliminated mainly by the kidneys with a half-life of about 16 hours. They do not accumulate in the body.
Indications for use
Comfoderm K cream is prescribed for the treatment of inflammatory skin diseases that are sensitive to therapy with topical glucocorticosteroids:
- dyshidrotic eczema;
- atopic dermatitis, neurodermatitis, childhood eczema;
- microbial eczema;
- true eczema;
- contact (allergic) dermatitis;
- simple contact dermatitis.
Contraindications
Absolute:
- tuberculous / syphilitic processes in the areas where the cream is applied;
- viral diseases (for example, shingles, chickenpox) in the area of application of Comfoderm K;
- rosacea, perioral dermatitis in the areas where the cream is applied;
- manifestations of a reaction to vaccination in the area of application of Comfoderm K;
- age up to 4 months;
- lactation period (when applying cream to the mammary glands);
- individual intolerance to any component of the drug.
Relative (Comfoderm K is prescribed under medical supervision):
- pregnancy;
- period of breastfeeding.
Instructions for use Comfoderm K: method and dosage
Comfoderm K cream is applied externally. It is applied daily in a thin layer once a day to the affected areas of the skin.
The recommended duration of continuous therapy in adults is up to 12 weeks, in children - up to 4 weeks.
Comfoderm K can be used in the treatment of subacute / acute inflammatory processes without pronounced wetness, with localization of pathology on the scalp and smooth skin, including skin prone to oily.
Side effects
Possible adverse reactions (> 10% - very often;> 1% and 0.1% and 0.01% and <0.1% - rarely; <0.01% - very rare; with an unknown frequency - in cases where it is impossible to determine the frequency of occurrence of violations):
- skin and subcutaneous tissues: rarely - skin depigmentation, perioral dermatitis, allergic reactions; with an unknown frequency - skin atrophy, striae, telangiectasia, acne-like skin changes (in the case when Comfoderm K is applied for more than 4 weeks and / or on an area with an area of 10% of the body surface);
- general disorders: rarely - hypertrichosis, folliculitis; very rarely - the formation of a vesicular rash, burning, itching, erythema; with an unknown frequency - systemic effects due to the absorption of the active substance.
Overdose
There is no risk of acute intoxication with a single excessive skin application or with unintentional ingestion.
With excessively prolonged / intense external use of Comfoderm K, skin atrophy (telangiectasia, thinning of the skin, striae) may develop. In such cases, therapy is canceled.
special instructions
In case of bacterial dermatoses / dermatomycosis, in addition to Comfoderm K, specific antibacterial or antimycotic treatment is required.
The cream is not intended for use in ophthalmology. It is necessary to avoid contact with mucous membranes and eyes.
After external use of Comfoderma K, glaucoma may develop (for example, with therapy with large doses, due to application to the skin around the eyes or very long-term use of occlusive dressings).
Application during pregnancy and lactation
According to the instructions, Comfoderm For women during pregnancy / lactation can be used only after assessing the benefit / risk ratio.
Breastfeeding mothers should not apply the cream to the mammary glands.
Pediatric use
For patients under 4 months of age, the drug is not prescribed.
Drug interactions
There are no data on the interaction of Comfoderma K with other drugs / substances.
Analogs
The analogue of Comfoderm K is Comfoderm M2.
Terms and conditions of storage
Keep out of reach of children at temperatures up to 25 ° C.
Shelf life is 2 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews of Comfoderma K
According to reviews, Comfoderm K is an effective drug that has a quick effect in the treatment of various skin diseases of an inflammatory nature. Of the advantages indicate a convenient dosing regimen. Among the disadvantages, the high cost is noted.
Price for Comfoderm K in pharmacies
The approximate price for Comfoderm K (1 tube of 15 g) is 296 rubles.
Comfoderm K: prices in online pharmacies
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Drug name Price Pharmacy |
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Comfoderm K cream 0.1% 15g 334 r Buy |
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Comfoderm K cream 0.1% 30g RUB 510 Buy |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
