Lantus
Instructions for use:
- 1. Pharmacological action
- 2. Release form
- 3. Analogs
- 4. Indications for use
- 5. Contraindications
- 6. Method of application
- 7. Drug interactions
- 8. Side effects
- 9. Terms and conditions of storage
Prices in online pharmacies:
from 2890 rub.
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Lantus - insulin glargine, solution for subcutaneous injection. A hypoglycemic agent, a long-acting human insulin analog.
Pharmacological action of Lantus
The active ingredient of Lantus, insulin glargine, a complete analogue of human insulin, is obtained by genetic recombination of the bacterium Escherichia coli (strain K12). In a neutral medium, the solubility is low, it completely dissolves in the Lantus preparation due to the acidic (pH = 4) medium of the injection solution.
Introduction to the subcutaneous fat of Lantus (insulin glargine):
- Due to the acidity of the solution, it promotes the formation of microprecipitate, which constantly release a small amount of insulin, which ensures a smooth profile of the pharmacokinetic curve and a prolonged action of the drug;
- Stimulates the biological effect and forms connections with insulin receptors in the body, similar in parameters to the effect and connections of endogenous insulin;
- Serves for the regulation of glucose metabolism, reducing its content in the blood by increasing its consumption by peripheral tissues, inhibits glucogenesis;
- Enhances protein synthesis, while suppressing proteolysis and lipolysis in adipocytes;
- Provides prolonged action of Lantus (insulin glargine) due to the reduced rate of absorption, allowing it to be administered once a day. The action of Lantus begins an hour after subcutaneous administration, lasts from 24 to 29 hours.
Lantus release form
Lantus is an almost colorless, transparent solution for subcutaneous injection, available in glass cartridges (3 ml) or vials (10 ml). For ease of use, the cartridge system "Opticlik" and the cartridge syringe pen "OptiSet" have been developed.
Lantus's analogs
The analogue of Lantus for the active ingredient (insulin glargine) is Lantus Solo Star, a solution for subcutaneous administration. Lantus analogs by the mechanism of action, drugs of one pharmacological subgroup - Levemir Penfill, Levemir FlexPen, solutions for subcutaneous administration.
Indications for use of Lantus
According to the instructions, Lantus (insulin glargine) is indicated in the case of:
- Type I diabetes mellitus (insulin dependent);
- Diabetes mellitus type II (non-insulin dependent) at the stages of resistance to the effects of oral hypoglycemic drugs, intercurrent diseases and pregnancy.
Contraindications
According to the instructions, Lantus is contraindicated:
- With increased sensitivity to insulin glargine or to any of the auxiliary components of the drug;
- Children under 6 years of age.
Pregnant women should be used with caution, under medical supervision.
Method of using Lantus
To use Lantus according to the instructions, the following rules must be strictly observed:
- Inject the drug into the subcutaneous fatty tissue of the thigh, shoulder, anterior abdominal wall, buttocks strictly at the same time, once a day, alternating the injection site every day;
- The dose and time of administration are selected individually by the attending physician, monotherapy or taking the drug in combination with other medicinal hypoglycemic drugs is allowed;
- Lantus injection solution should not be diluted or mixed with other insulin preparations;
- You should not inject Lantus intravenously, the most effective effect of the drug is manifested when administered subcutaneously;
- When switching to Lantus from other insulin preparations, it is necessary to carefully monitor the blood glucose level for the first 2-3 weeks.
The scheme for switching from other hypoglycemic drugs to Lantus should be drawn up by the attending physician based on the results of a medical examination, taking into account the individual characteristics of the patient. In the future, the dosage regimen can be adjusted with an increase in insulin sensitivity, due to an improved regulation of metabolism. Correction of the scheme may be required when changing lifestyle, social conditions, patient weight or other factors provoking an increase in the predisposition to hyper- or hypoglycemia.
Drug interactions
Drug interactions with a number of drugs can affect glucose metabolism. The following drugs affect the action of Lantus according to the instructions:
- Drugs that enhance the effect of Lantus (insulin glargine) - ACE inhibitors, oral hypoglycemic drugs, MAO inhibitors, fluoxetine, fibrates, disopyramide, propoxyphene, pentoxifylline, sulfa drugs and salicylates;
- Drugs that weaken the effect of Lantus (insulin glargine) - corticosteroids, diazoxide, danazol, diuretics, gestagens, estrogens, glucagon, isoniazid, somatotropin, phenothiazine derivatives, sympathomimetics (epinephrine, terbutaline, salbutamol), olyzapine inhibitors or protease inhibitors (some, thyroid hormones;
- Both enhance and weaken the effect of Lantus (insulin glargine) beta-blockers, lithium salts, clonidine, alcohol;
- The instability of the amount of glucose in the blood with the change of hypoglycemia to hyperglycemia can cause the simultaneous administration of Lantus with pentamidine;
- Signs of adrenergic counterregulation may be reduced or absent when taking sympatholytic drugs - guanfacine, clonidine, reserpine and beta-blockers.
Side effects of Lantus
The most common side effect of Lantus, according to reviews, is hypoglycemia, which occurs when the dose of insulin taken exceeds the need. Repeated severe attacks of hypoglycemia can lead to damage to the central nervous system and pose a real threat to the patient's life. The first signs of hypoglycemia are manifested by the activation of the sympathoadrenal system and are expressed by a constant feeling of hunger, irritability, profuse cold sweating, and tachycardia. The next stage is neuropsychiatric disorders, expressed by fainting, convulsive syndrome, clouded consciousness.
The action of Lantus, according to reviews, may also have an undesirable effect on the organs of vision. A wide range of changes in blood glucose affects tissue turgor and refractive index of the eye lens, causing temporary visual impairment. When the glucose level is normal for a long time, the development of diabetic retinopathy stops. In the presence of proliferative retinopathy, if not treated with photocoagulation, during periods of severe hypoglycemia, transient loss of vision may develop.
With prolonged use of Lantus, according to reviews, at the injection sites, a local delay in the absorption of the drug and tissue lipodystrophy may develop, especially in case of violation of the rule on the constant change of injection sites.
In rare cases, in patients, according to reviews, Lantus can provoke local (area of administration) and general allergic reactions - redness, itching, hives, inflammation or swelling.
Storage conditions and periods
Lantus should be stored in a dark place, out of the reach of children, at a temperature of 2 ° to 8 ° C. Shelf life - 3 years from the date on the package. The shelf life of the filled OptiSet syringe pens and OptiKlik systems is 4 weeks, at T 25 ° C, in a dark place.
Lantus: prices in online pharmacies
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Drug name Price Pharmacy |
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Lantus SoloStar 100 U / ml solution for subcutaneous administration 3 ml 5 pcs. 2890 RUB Buy |
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
