Imunofan
Imunofan: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Drug interactions
- 11. Analogs
- 12. Terms and conditions of storage
- 13. Terms of dispensing from pharmacies
- 14. Reviews
- 15. Price in pharmacies
Latin name: Imunofan
ATX code: L03AX
Active ingredient: arginyl-alpha-aspartyl-lysyl-valyl-tyrosyl-arginine (arginil-alfa-aspartil-lysil-valil-tyrosil-arginine)
Producer: Bionoks NPP, LLC (Russia)
Description and photo update: 2019-14-08
Prices in pharmacies: from 461 rubles.
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Imunofan is an immunostimulating drug with hepatoprotective, detoxifying, antioxidant effects.
Release form and composition
Dosage forms of Imunofan:
- Solution for intramuscular (i / m) and subcutaneous (s / c) administration: clear, colorless liquid (5 or 10 ampoules in a blister strip, in a cardboard box 1 or 2 packs);
- Suppositories for rectal use: torpedo-shaped with a homogeneous structure from white to white with a yellowish tinge, may have a slight specific odor (5 or 10 pieces in a blister strip, in a cardboard box 1 or 2 packs);
- Dosed spray for nasal use: colorless, transparent or slightly opalescent liquid, a slight specific odor is allowed (8.5 ml each in a plastic bottle with a dosing device, 1 bottle in a cardboard box).
The active substance is imunofan:
- 1 ml of solution - 50 μg;
- 1 suppository - 100 mcg;
- 1 spray dose - 50 mcg.
Auxiliary components:
- Solution: sodium chloride, glycine, water for injection;
- Suppositories: glycine, tween 80, solid fat, purified water;
- Spray: benzalkonium chloride, sodium edetate (Trilon B), sodium chloride, glycine, purified water.
Pharmacological properties
Pharmacodynamics
When using Imunofan, three main effects are observed: weakening of multidrug resistance caused by proteins of the transmembrane transport pump of the cell, restoring the balance of the oxidative-antioxidant reaction of the body and regenerating the immune system.
Pharmacokinetics
The effect of the drug appears within 2-3 hours after administration (fast phase) and lasts for 4 months (medium and slow phases).
The fast phase begins 2–3 hours after the application of Imunofan and lasts up to 2–3 days. First of all, it is characterized by a detoxification effect, which is expressed in the inhibition of the breakdown of phospholipids of the cell membrane and the production of arachidonic acid with a further decrease in blood cholesterol levels and the synthesis of inflammatory mediators, normalization of lipid peroxidation processes and an increase in antioxidant protection by activating the synthesis of lactoferrin and ceruloplasmin and stimulating activity catalase. In case of infectious and toxic lesions of the liver, Imunofan suppresses the activity of transaminases and reduces the content of bilirubin in the blood serum, and also prevents cytolysis.
The middle phase after administration of the drug begins in 2-3 days and lasts up to 7-10 days. During this period, phagocytosis reactions intensify, and intracellular bacteria and viruses die.
The slow phase begins on the 7-10th day and lasts about 4 months. At this time, the immunoregulatory effect of Imunofan is noted, which contributes to the restoration of the disturbed parameters of humoral and cellular immunity. An activation of the production of specific antibodies is also observed, and the immunoregulatory index is normalized. The effect of Imunofan on the synthesis of antibacterial and antiviral antibodies of a specific nature is identical to the effect of certain therapeutic vaccines. Unlike the latter, the drug does not significantly affect the production of reaginic antibodies of the IgE class (immunoglobulin E) and does not enhance the immediate type of hypersensitivity reaction. The drug increases the production of IgA (immunoglobulin A) with its congenital deficiency.
Imunofan effectively inhibits multidrug resistance of tumor cells and increases their sensitivity to the action of cytostatic drugs.
Indications for use
According to the instructions, Imunofan is indicated for the prevention and treatment of chronic inflammatory diseases of various etiologies, immunodeficiency and toxic conditions.
In addition, the drug is prescribed:
- Solution for injection and rectal suppositories - for vaccination against viral and bacterial infections as an adjuvant (only for adults);
- Nasal spray - for the treatment of acute forms of infectious and inflammatory pathologies.
Contraindications
- Age up to 2 years;
- Hypersensitivity to the components of Imunofan.
Additionally, solution for injections and rectal suppositories are contraindicated for use in pregnancy complicated by Rh-conflict.
It is recommended to use a nasal spray with caution during pregnancy and breastfeeding.
Instructions for the use of Imunofan: method and dosage
The solution is intended for s / c or i / m injections, the drug is prescribed in courses, the daily (single) dose is 50 mcg.
Suppositories are used rectally in a daily (single) dose of 100 μg.
The spray is used intranasally, for this it is necessary (with the vertical position of the bottle and the patient's head) to insert the sprayer into the nasal passage and press all the way on the wide rim of the device. The use of a new bottle should be started by filling the dosing pump by pressing 3-4 times on the wide rim of the spray device. One spray dose contains 50 mcg of Imunofan. The maximum daily dose is 200 mcg.
The frequency of application of suppositories and injections of Imunofan - 1 time per day, spray - 1-2 times. The course of treatment depends on the clinical indications and the patient's age:
- Oncological pathologies in the scheme of combined radical (surgery, chemoradiation therapy) treatment: 8-10 injections or suppositories (1 dose of spray in each nasal passage for 8-10 days) before surgery and chemoradiation therapy, then at intervals of 15-20 days between courses throughout the entire period of therapy;
- A widespread tumor process (III-IV stage of oncological disease) of various localization (complex or symptomatic therapy): 8-10 injections or suppositories (1 dose in each nasal passage for 8-10 days), this course should be repeated after a break of 15 -20 days throughout the entire period of therapy;
- Malignant diseases of the lymphoid and hematopoietic systems in children: 10-20 injections or suppositories throughout the entire period of chemoradiation therapy and after completion to prevent the development of toxicosis;
- Papillomatosis of the larynx and oropharynx in children (as part of complex therapy): 10 injections or suppositories;
- Cytomegalovirus and herpes infection, cryptosporidiosis, toxoplasmosis, pneumocystosis, chlamydia: 15-20 injections or suppositories, or 1 dose of spray in each nasal passage 2 times a day for 10-15 days, repetition of courses is possible after a break of 2-4 weeks;
- HIV infection (as part of complex therapy): 15-20 injections or suppositories (1 dose in each nasal passage for 10-15 days), repeated courses are possible after a break of 2-4 weeks;
- Chronic forms of viral hepatitis and brucellosis: 15-20 injections or suppositories (1 dose in each nasal passage for 10-15 days), to prevent relapses after 2-3 months, it is recommended to carry out repeated courses of treatment (for a nasal spray - after 4 6 months);
- Diphtheria: 8-10 injections or suppositories, carriers of diphtheria bacteria - 1 time in 3 days, treatment period - 3-5 injections or suppositories;
- Psoriasis: 15-20 injections or suppositories;
- Burns of III-IV degree with signs of toxemia and septicotoxemia, septic endocarditis, purulent-septic complications after surgery, long-term non-healing wounds of the extremities: 7-10 injections or suppositories, in severe cases it is recommended to continue treatment for up to 20 days;
- Vaccine prophylaxis: for adults only - 1 injection (1 suppository) on the day of vaccination.
In the treatment of broncho-obstructive syndrome, rheumatoid arthritis, cholecystopancreatitis, Imunofan is prescribed 1 time in 3 days, the treatment period consists of 8-10 suppositories or injections, if necessary, the course should be extended according to the same scheme to 20 procedures.
The use of the spray for acute and chronic infectious and inflammatory diseases with symptoms of intoxication and immunodeficiency is carried out as part of a complex therapy daily, 1 dose in each nasal passage 2 times a day, for 10-15 days.
Side effects
The development of side effects is possible with individual drug intolerance.
Overdose
At the moment, no cases of Imunofan overdose have been registered.
special instructions
Due to the activation of phagocytosis, a short exacerbation of foci of chronic inflammation can be observed, which are maintained due to the preservation of the functional activity of viral or bacterial antigens.
Influence on the ability to drive vehicles and complex mechanisms
The use of Imunofan does not affect the ability to drive vehicles and perform potentially hazardous types of work that require increased concentration and quick psychomotor reactions.
Application during pregnancy and lactation
Since the use of Imunofan during pregnancy and breastfeeding has not been sufficiently studied, it is prescribed only in cases where the potential benefit of treatment for the mother significantly outweighs the possible risks to the fetus.
Drug interactions
The simultaneous use of all dosage forms of the drug is possible with steroid and non-steroidal anti-inflammatory drugs.
Cases of interaction of Imunofan injections with other drugs have not been established.
Nasal spray helps to overcome resistance to glucocorticosteroid therapy, increases the therapeutic effect of other drugs.
Analogs
Imunofan analogs are: Alkimer, Immunal, Arbidol, Anaferon, Groprinosin, Wobenzim, IRS 19, Timogen.
Terms and conditions of storage
Store in a dry, dark place at a temperature of 2 to 10 ° C. Keep out of the reach of children.
Shelf life is 2 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Imunofan
According to reviews, Imunofan in the form of a solution for subcutaneous and intramuscular administration in most cases has a beneficial effect on the immune system after the first injection. Patients note a significant improvement in their condition and positive dynamics, which is observed during therapy when using Imunofan both in the form of injections, and in the form of suppositories or a spray.
Experts consider the drug to be quite effective for the treatment of various infectious and viral diseases. Most consider suppositories to be the most convenient form for treatment.
Price for Imunofan in pharmacies
On average, the price of Imunofan in the form of a spray is about 820‒1083 rubles. Suppositories for rectal use can be purchased for 456-584 rubles (5 pcs are included in the package). A solution for intramuscular or subcutaneous administration will cost about 493-596 rubles (the package includes 5 ampoules).
Imunofan: prices in online pharmacies
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Drug name Price Pharmacy |
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Imunofan 45 mcg / ml solution for intramuscular and subcutaneous administration 1 ml 5 pcs. 461 r Buy |
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Imunofan 90 mcg rectal suppositories 5 pcs. 467 r Buy |
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Imunofan suppositories rectal. 90μg 5 pcs. RUB 545 Buy |
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Imunofan 45 mcg / dose 40 doses nasal spray dosed 8.5 ml 1 pc. 850 RUB Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
