Doverin - Instructions For The Use Of Tablets, Price, Analogues, Reviews

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Doverin - Instructions For The Use Of Tablets, Price, Analogues, Reviews
Doverin - Instructions For The Use Of Tablets, Price, Analogues, Reviews

Video: Doverin - Instructions For The Use Of Tablets, Price, Analogues, Reviews

Video: Doverin - Instructions For The Use Of Tablets, Price, Analogues, Reviews
Video: Drotaverine hydrochloride (No-spa tablet 40 mg/80 mg )uses and side effects 2024, November
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Trust

Doverin: instructions for use and reviews

  1. 1. Release form and composition
  2. 2. Pharmacological properties
  3. 3. Indications for use
  4. 4. Contraindications
  5. 5. Method of application and dosage
  6. 6. Side effects
  7. 7. Overdose
  8. 8. Special instructions
  9. 9. Application during pregnancy and lactation
  10. 10. Use in childhood
  11. 11. In case of impaired renal function
  12. 12. For violations of liver function
  13. 13. Drug interactions
  14. 14. Analogs
  15. 15. Terms and conditions of storage
  16. 16. Terms of dispensing from pharmacies
  17. 17. Reviews
  18. 18. Price in pharmacies

Latin name: Doverine

ATX code: A03AD02

Active ingredient: drotaverine (Drotaverine)

Producer: Anzhero-Sudzhensky KhFZ, LLC (Russia)

Description and photo update: 2020-24-06

Prices in pharmacies: from 58 rubles.

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Doverin tablets
Doverin tablets

Doverin is a drug with an antispasmodic effect.

Release form and composition

The product is produced in the form of tablets: flat-cylindrical, yellow with a green tint, with a chamfer (6, 10 or 12 pieces in a blister strip packaging; 50 pieces in a glass or polymer jar; in a cardboard box instructions for using Doverin and 1, 2, 3, 4 or 5 packs or 1 can).

1 tablet contains:

  • active substance: drotaverine hydrochloride - 40 mg;
  • additional components: potato starch, lactose monohydrate (milk sugar), magnesium stearate, water-soluble methylcellulose, talc.

Pharmacological properties

Pharmacodynamics

Drotaverine is a myotropic antispasmodic derived from isoquinoline. The active substance inhibits the enzyme type IV phosphodiesterase (PDE-4), resulting in the accumulation of intracellular cyclic adenosine monophosphate (cAMP) and, as a result, inactivation of myosin light chain kinase, which provides relaxation of smooth muscle tissue.

The use of the drug is effective for smooth muscle spasms of neurogenic and muscular etiology. Trust, regardless of the type of autonomic innervation, has an effect on the smooth muscles of the genitourinary, biliary and vascular systems, as well as the gastrointestinal tract (GIT). In the myocardium and vessels of smooth muscles, the cAMP hydrolyzing enzyme is mainly PDE-3, and therefore, despite the high antispasmodic activity of drotaverine hydrochloride, its significant therapeutic effect on the cardiovascular system (CVS) and the occurrence of serious adverse reactions from the latter are not recorded. …

Pharmacokinetics

Doverin is intensively absorbed in the digestive tract. After oral administration, the half-absorption period of drotaverine is 12 minutes, the bioavailability is almost 100%. The agent is characterized by a uniform distribution over the tissues, it penetrates into the cells of smooth muscles, but does not pass through the blood-brain barrier. The active substance is mostly excreted in the urine and to a small extent in the bile.

Indications for use

Doverin is indicated for the relief of smooth muscle spasms caused by the following diseases:

  • cholecystitis, pericholecystitis, cholecystolithiasis, cholangiolithiasis, papillitis and other lesions of the biliary tract;
  • ureterolithiasis, nephrolithiasis, pyelitis, tenesmus of the bladder, cystitis and other pathologies of the urinary tract.

As a means of auxiliary therapy, the drug is recommended for use in the following cases:

  • tensor headache;
  • spasms of smooth muscles of the gastrointestinal tract in diseases such as gastritis, peptic ulcer and 12 duodenal ulcer, enteritis, spasms of the cardia and pylorus, colitis, including mucous colitis with flatulence and spastic colitis, accompanied by constipation;
  • gynecological diseases, including dysmenorrhea.

Contraindications

Absolute:

  • severe renal and / or hepatic impairment;
  • low cardiac output syndrome (severe heart failure);
  • age up to 18 years;
  • lactation period;
  • glucose-galactose malabsorption, lactase deficiency, lactose intolerance;
  • hypersensitivity to any component of the antispasmodic agent.

Relative (you must use Doverin tablets with extreme caution):

  • severe atherosclerosis of the coronary arteries;
  • arterial hypotension;
  • glaucoma;
  • hyperplasia of the prostate;
  • period of pregnancy.

Doverin, instructions for use: method and dosage

Doverin tablets are taken orally.

Recommended dosage regimen: 1-2 tablets (40-80 mg) 2-3 times a day.

Side effects

  • CVS: lowering blood pressure, heart palpitations;
  • nervous system: dizziness, insomnia, headache;
  • Gastrointestinal tract: nausea, constipation;
  • immune system: allergic reactions, including allergic dermatosis.

Overdose

Symptoms of an overdose of drotaverine can be atrioventricular block, paralysis of the respiratory center, cardiac arrest.

In the case of oral use of an excessive dose of the drug, it is necessary to stop taking Doverin and conduct symptomatic therapy. There is no specific antidote.

special instructions

In the treatment of gastric ulcer and duodenal ulcer, the antispasmodic agent should be used in combination with antiulcer drugs.

Influence on the ability to drive vehicles and complex mechanisms

Drotaverine, taken orally in therapeutic doses, does not affect the ability to drive and perform work requiring increased attention. If any undesirable reactions develop, the question of driving vehicles and working with mechanisms is subject to individual consideration. If dizziness occurs after taking the pills, you should avoid engaging in potentially hazardous activities, including driving and operating machinery.

Application during pregnancy and lactation

If necessary, use of the drug during pregnancy requires caution.

Doverin is contraindicated for lactating women.

Pediatric use

Doverin is not prescribed for patients under 18 years of age.

With impaired renal function

Treatment with the drug is contraindicated in severe renal impairment.

For violations of liver function

Doverin is contraindicated in severe hepatic dysfunction.

Drug interactions

  • other antispasmodics (including M-anticholinergics): the effect of these funds is enhanced;
  • quinidine, procainamide, tricyclic antidepressants: the risk of arterial hypotension associated with the use of these drugs is aggravated;
  • morphine: its spasmogenic activity decreases;
  • phenobarbital: the spasmolytic effect of drotaverine increases;
  • levodopa: the antiparkinsonian effect of this substance is weakened.

Analogs

Doverin's analogues are Drotaverin-Teva, Spazmonet, No-shpa, Drotaverin forte, Drotaverin-ALSI, Spazmol, Spakovin, No-shpa forte, Spazoverin, Drotaverin-SOLOfarm, etc.

Terms and conditions of storage

Store in a place protected from moisture and light, out of reach of children, at a temperature not exceeding 25 ° C.

The shelf life is 3 years.

Terms of dispensing from pharmacies

Available without a prescription.

Reviews about Trust

Extremely rare reviews of the Trust are mostly positive. The tool has proven itself well in relieving smooth muscle spasms and pain. According to patients, the antispasmodic, being an analogue of the popular No-shpa, exhibits no less therapeutic efficacy than this drug, but at the same time has a lower cost. There are no complaints about negative drug reactions.

The price of Doverin in pharmacies

The approximate price for Doverin in the form of tablets (40 mg) is 60-80 rubles. for 24 pcs. in the package and 110-120 rubles. for 48 pcs. packaged.

Doverin: prices in online pharmacies

Drug name

Price

Pharmacy

Doverin 40 mg tablets 24 pcs.

RUB 58

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Doverin tablets 40mg 24 pcs.

RUB 78

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Doverin 40 mg tablets 48 pcs.

112 RUB

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Doverin tablets 40mg 48 pcs.

113 RUB

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Anna Kozlova
Anna Kozlova

Anna Kozlova Medical journalist About the author

Education: Rostov State Medical University, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!

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