Diacerein
Diacerein: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. In case of impaired renal function
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Diacerein
ATX code: M01AX21
Active ingredient: Diacerein (Diacereinum)
Manufacturer: Micro Labs (India); Macleods Pharmaceuticals (India)
Description and photo update: 18.10.2018
Diacerein is an anti-inflammatory non-steroidal drug.
Release form and composition
The drug is produced in the form of capsules: gelatinous hard, size No. 1, blue, with black marking Dr. REDDY'S - on the lid, and Movagain white markings on the body. The capsule contains a yellow granular powder. The drug is packaged in polyethylene laminated aluminum strips of 10 capsules, in a cardboard box of 3 or 6 strips.
1 capsule contains:
- active substance: diacerein - 50 mg;
- excipients: lactose monohydrate - 222.5 mg, croscarmellose sodium - 18 mg, colloidal silicon dioxide - 3 mg, hypromellose 3 cps - 3 mg, magnesium stearate - 1.5 mg;
- capsule: propyl parahydroxybenzoate, methyl parahydroxybenzoate, sodium lauryl sulfate, titanium dioxide (E171), blue proprietary dye (E131), azorubin dye (E122), water, gelatin;
- ink: black - ethanol, shellac, isopropanol, butanol, iron oxide black dye (E172), macrogol, concentrated ammonia solution; white - ethanol, shellac, isopropanol, titanium dioxide, concentrated ammonia solution, polysorbate-80.
Pharmacological properties
Pharmacodynamics
A diacetylated rhein derivative and an anthraquinoline derivative is metabolized to the active metabolite of rhein, thereby reducing the activity of interleukin-1, which plays a special role in the development of inflammation and cartilage degradation in osteoarthritis.
It inhibits the action of other cytokines (including TNF alpha, interleukin-6). Effective after 2-4 weeks.
Pharmacokinetics
Absorption from the gastrointestinal tract (gastrointestinal tract) is fast, bioavailability when taken together with food increases by 25%.
The time to reach the highest concentration (Tc max) is 144 minutes. With a single dose of 50 mg, the maximum concentration (C max) is 3.15 mg / l, with repeated administration, due to the cumulation of the drug, C max increases. Fully deacetylated to rhein. The connection of rhein with albumin (proteins) reaches 100%. The Rhine crosses the blood-brain and placental barriers.
The half-life (T 1/2) is 255 minutes. It is excreted by the kidneys in the form of glucuronide (60%), unchanged (20%) and in the form of sulfate (20%).
Indications for use
- primary osteoarthritis;
- secondary osteoarthritis.
Contraindications
- lactose intolerance;
- lack of lactase;
- impaired absorption of glucose-galactose;
- pregnancy;
- lactation period;
- high sensitivity to the components of the drug (also to anthraquinone medicines);
- age up to 18 years.
The drug is used with caution in case of irritation of the lower intestines and in chronic renal failure.
Instructions for the use of Diacerein: method and dosage
According to the instructions, Diacerein is administered orally (inside) after meals, the capsule should be swallowed whole with a sufficient amount of water. Apply one capsule (50 mg) twice a day (morning and evening).
During the first two weeks, when taking the drug, there may be an acceleration of transit in the intestine, in this case, treatment should be started with one capsule per day. It must be taken in the evening, simultaneously with food, for four weeks, then the dose is increased to two capsules (100 mg) per day.
The course of treatment is at least four months.
Side effects
- digestive system: nausea, vomiting, abdominal pain, diarrhea, general malaise;
- allergic reactions: rash, itching.
Intensive coloration of urine (depending on pH) from brown to yellow is infrequently noted (there is no clinical significance, does not require dose reduction or drug withdrawal).
Overdose
Overdose may cause symptoms such as weakness and diarrhea.
With severe diarrhea, monitoring of the electrolyte composition of the plasma is necessary.
special instructions
Before the onset of a therapeutic effect, it is possible to combine it with analgesic drugs (including non-steroidal anti-inflammatory drugs). Periodic monitoring of blood parameters, functional urine samples, liver is required. If renal function worsens, the dose of the drug must be reduced.
Influence on the ability to drive vehicles and complex mechanisms
The effect of the drug on the speed of psychomotor reactions and concentration of attention when driving vehicles and other theoretically dangerous activities is unlikely.
Application during pregnancy and lactation
Studies on the use of the drug during pregnancy and lactation, confirming safety, have not been conducted. There is no information on the effect on fetal development.
With impaired renal function
For patients with chronic renal failure whose creatinine clearance is less than 30 ml / min, it is necessary to reduce the daily dose of diacerein to 50 mg, and subsequently adjust it in accordance with clinical efficacy and tolerability. In chronic renal failure, the drug must be used with caution.
Drug interactions
Antacids help to reduce the absorption of the drug. When taken simultaneously with medicines that affect the intestinal microflora (including antibiotics), as well as with substances that change the quality of the intestinal contents and the rate of emptying (fiber), the frequency of side effects from the intestines increases.
Medicines containing aluminum hydroxide and / or magnesium hydroxide reduce the bioavailability of diacerein.
The simultaneous use of laxatives is not recommended.
Analogs
Diacerein analogues are: Arthrodarin, Artroker, Diartrin, Diaflex Rompharm, Diacerein-Mac.
Terms and conditions of storage
Store in a dry place, out of the reach of light, at a temperature not exceeding 25 ° C. Keep out of the reach of children.
Shelf life is 2 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Diacerein
Reviews about Diacerein are different. Those who took the drug note the appearance of diarrhea (mainly with prolonged treatment), some had swelling in the legs and pain in the liver.
Diacerein price in pharmacies
There is no reliable data on the price of Diacerein.
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
