Gentamicin-AKOS
Gentamicin-AKOS: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. Use in the elderly
- 13. Drug interactions
- 14. Analogs
- 15. Terms and conditions of storage
- 16. Terms of dispensing from pharmacies
- 17. Reviews
- 18. Price in pharmacies
Latin name: Gentamicin-AKOS
ATX code: J.01. GB03
Active ingredient: Gentamicin (Gentamicin)
Manufacturer: Sintez JSC (Russia)
Description and photo update: 2018-25-10
Prices in pharmacies: from 45 rubles.
Buy
Gentamicin-AKOS is a bactericidal antibiotic for external use.
Release form and composition
Dosage form - ointment for external use 1%: from white to yellow (15 g in aluminum tubes, each tube is inserted into a cardboard box).
The composition of the ointment per 100 mg:
- active substance: gentamicin (in the form of sulfate) - 0.1 mg;
- additional components: solid petroleum paraffin, medical vaseline.
Pharmacological properties
Pharmacodynamics
Gentamicin-AKOS is a broad-spectrum antibacterial agent from the aminoglycoside group.
The mechanism of action of the drug is due to its ability to bind to the 30S ribosome subunit and disrupt protein synthesis, which prevents the formation of a complex of transport and informational ribonucleic acid. As a result, the genetic code is incorrectly read and non-functional proteins are formed, and polyribosomes are cleaved and lose the ability to synthesize protein.
Unlike other antibiotics, gentamicin has bactericidal properties: in high doses, it reduces the barrier functions of cell membranes and causes the death of bacteria.
It is characterized by high activity against bacterial infectious skin diseases caused by Enterobacter aerogenes, Proteus vulgaris, Staphylococcus spp., Escherichia coli, Streptococcus spp., Pseudomonas aeruginosa.
Pharmacokinetics
After external use, gentamicin is practically not absorbed.
Absorption occurs quickly from large areas, from damaged skin (wound or burn) or from a surface covered with granulation tissue.
Indications for use
According to the instructions, Gentamicin-AKOS is intended for the treatment of bacterial infections of the skin and soft tissues caused by microflora sensitive to the drug: furunculosis, pyoderma (including gangrenous), paronychia, sycosis, superficial folliculitis.
Also, the ointment is used to treat infected diseases, such as acne vulgaris, burns (including plants), skin abscesses and cysts, wounds (including surgical and sluggish ones), ulcers (including varicose), dermatitis (including seborrheic, eczematous and contact), secondary bacterial infection in viral and fungal skin infections.
Contraindications
Gentamicin-AKOS is contraindicated in case of hypersensitivity to its components or other aminoglycosides in history.
The drug should be used with caution in the following cases:
- renal failure (including severe chronic with azotemia and uremia);
- neuritis of the auditory nerve;
- botulism;
- parkinsonism;
- myasthenia gravis;
- the need for use on extensive skin surfaces;
- pregnancy and lactation;
- elderly age;
- prematurity of children;
- neonatal period.
Instructions for use of Gentamicin-AKOS: method and dosage
Ointment Gentamicin-AKOS is applied externally. It should be applied 3-4 times a day with a thin layer on the affected areas. You can cover with a bandage if necessary.
The duration of therapy is set individually. Usually it is 7-14 days.
If there is no therapeutic effect within 1 week, you should consult your doctor.
Side effects
Gentamicin-AKOS can cause allergic reactions: local - skin flushing, itching, burning sensation, skin rash; generalized (rarely) - angioedema, fever, eosinophilia.
When applying the ointment to large skin surfaces, there is a risk of systemic effects.
Overdose
After external use, gentamicin is practically not absorbed, so the likelihood of developing overdose symptoms is extremely low.
special instructions
Long-term treatment should be carried out under the control of an antibiogram, since there is a risk of developing resistance. If this happens, it is necessary to discontinue the drug and prescribe the appropriate therapy.
When applying the ointment to large areas of the body, the likelihood of a resorptive effect should be taken into account, especially in patients with chronic renal failure.
Influence on the ability to drive vehicles and complex mechanisms
There are no data on the negative effect of gentamicin on human psychomotor functions.
Application during pregnancy and lactation
During pregnancy and lactation, this remedy should be used with caution.
Pediatric use
With caution, Gentamicin-AKOS ointment should be used in the treatment of premature and newborn babies.
With impaired renal function
With impaired renal function, caution is required.
Patients with chronic renal failure should take into account the likelihood of the resorptive effect of gentamicin, especially if it is necessary to apply the ointment to large areas of the skin and / or use the drug for a long time.
Use in the elderly
In old age, Gentamicin-AKOS should be used with caution.
Drug interactions
Simultaneously with Gentamicin-AKOS and immediately after its cancellation (if the drug has been used for a long time and / or on large surfaces of the body), drugs with otonephrotoxic effects should not be used.
Analogs
Analogs of Gentamicin-AKOS are: Gentamicin, Gentamicin-K, Gentamicin sulfate, Gentamicin-Ferein.
Terms and conditions of storage
Shelf life - no more than 3 years, subject to the temperature regime recommended by the manufacturer - 8-15 ° С.
Keep out of the reach of children.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Gentamicin-AKOS
According to reviews, Gentamicin-AKOS is an inexpensive, effective and fast-acting agent that eliminates dry skin, quickly heals wounds, burns, cracks, insect bites, sores, etc. The disadvantage of the ointment is its property to leave marks on clothes.
Price for Gentamicin-AKOS in pharmacies
The price of Gentamicin-AKOS for 1 tube of 15 g varies from 63 to 100 rubles.
Gentamicin-AKOS: prices in online pharmacies
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Drug name Price Pharmacy |
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Gentamicin-AKOS 0.1% ointment for external use 15 g 1 pc. RUB 45 Buy |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
