Vitamin E Zentiva
Vitamin E Zentiva: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Instructions for the use of Vitamin E Zentiva: method and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews Vitamin E Zentiva
- 16. Price in pharmacies
Latin name: Vitamin E Zentiva
ATX code: A11HA03
Active ingredient: Vitamin E (Vitamin E)
Manufacturer: Zentiva as (Slovak Republic)
Description and photo update: 2018-24-10
Prices in pharmacies: from 137 rubles.
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Vitamin E Zentiva - Vitamin E (tocopherol).
Release form and composition
Vitamin E dosage form Zentiva - capsules: oval, red; content - transparent light yellow oil. Packing: dark glass bottles - 30 capsules at a dose of 100 and 200 mg, 20 or 30 capsules at a dose of 400 mg; 1 bottle is packed in a cardboard box.
Active ingredient: alpha-tocopherol acetate, in 1 capsule - 100, 200 or 400 mg.
Additional components and their content (in capsules 100/200/400 mg):
- excipient: sunflower oil - 7.5 / 15/30 mg;
- the composition of the capsule shell: methyl parahydroxybenzoate - 0.049 / 0.072 / 0.112 mg, glycerol 85% - 27.46 / 39.934 / 62.397 mg, purified water - 32.898 / 47.851 / 74.768 mg, gelatin - 49.38 / 71.824 / 112.225 mg, crimson Ponso dye 4R (E124) - 0.22 / 0.319 / 0.499 mg.
Pharmacological properties
Pharmacodynamics
Alpha-tocopherol (vitamin E) is the most effective of tocopherols - biologically active substances that protect the intermediate compounds of cellular respiration from oxidation of the functional groups of their molecules. They have the ability to oxidize to semiquinones, which are reduced to tocopherols in the body. If their amount in the human body is sufficient, they protect the metabolites of cellular respiration and unstable mediators from oxidation. They play a buffer role in redox processes at the level of cellular metabolism under pathological conditions.
Vitamin E, entering the body, binds free oxygen radicals, acts as a cellular antioxidant, prevents erythrocyte hemolysis, participates in cell proliferation, protein and heme biosynthesis, as well as other important processes of tissue metabolism. Alpha-tocopherol strengthens the walls of blood vessels, is involved in the development and functioning of connective tissue.
Being a natural antioxidant, vitamin E inhibits lipid peroxidation by free radicals, is used to maintain normal erythrocyte resistance, and activates phagocytosis. In large doses, this vitamin is able to prevent platelet aggregation.
Pharmacokinetics
Alpha-tocopherol is absorbed mainly from the duodenum - from 20 to 40%, important conditions for its absorption are the normal functioning of the pancreas, the presence of fats and bile salts. The degree of absorption decreases with increasing dose of the drug.
The maximum concentration reaches within 4 hours. It accumulates in all tissues (especially in adipose tissue) and organs.
Vitamin E crosses the placenta in small quantities: 20-30% of the concentration in the mother's blood enters the fetal blood. Penetrates into breast milk.
It is excreted mainly through the gastrointestinal tract with bile - over 90%. Less than 6% of the substance is excreted by the kidneys in the form of metabolites, including glucuronides.
Indications for use
Vitamin E Zentiva is used to prevent and treat vitamin E deficiency, including in the following cases:
- heavy physical activity;
- the recovery period after serious illnesses, operations, injuries;
- menstrual irregularities (as part of complex hormonal therapy);
- chronic hepatitis (as part of combination therapy);
- proliferative and degenerative changes in the musculoskeletal system: amyotrophic lateral sclerosis, muscular dystrophy (as part of complex therapy).
Contraindications
- acute myocardial infarction;
- childhood;
- increased sensitivity to the components of Vitamin E Zentiva.
The drug should be used with caution in the presence of an increased risk of thromboembolism, after myocardial infarction, in severe cardiosclerosis.
At a dose of more than 400 IU (1.21 IU - 1 mg), vitamin E can worsen the course of hypothrombinemia caused by vitamin K deficiency, so caution is also required in this case.
Instructions for the use of Vitamin E Zentiva: method and dosage
The drug is taken orally.
Vitamin E Zentiva is prescribed only for adults.
Recommended dosage regimens:
- hypovitaminosis E: 100 mg per day until the condition normalizes;
- increased physical activity: 100 mg per day for the entire period of stress;
- degenerative and proliferative changes in the musculoskeletal system: 100 mg per day for 1–2 months;
- chronic hepatitis: 100 mg once a day;
- recovery period after serious illness / surgery / injury: 100 mg per day for 1-2 weeks;
- menstrual irregularities: 300-400 mg every other day in succession, starting from the 17th day of the cycle until the last day of the cycle (the day before the first day of menstruation).
Side effects
Vitamin E Zentiva, taken at the recommended dosage, usually does not cause side effects.
In some cases, it is possible:
- from the gastrointestinal tract: gastralgia, nausea, diarrhea;
- from the vascular system: pulmonary embolism, thrombophlebitis;
- on the part of metabolism and nutrition: an increase in the concentration of cholesterol in the blood serum, an increase in the activity of creatine phosphokinase, hypercreatinuria;
- from the immune system: allergic reactions.
Overdose
With prolonged intake of high doses of vitamin E (400-800 mg per day), the following symptoms of overdose may occur: visual impairment, dizziness, headache, fatigue, fainting, diarrhea, nausea, with epidermolysis bullosa - the growth of white hair in areas of alopecia.
With prolonged use of very high doses of alpha-tocopherol (more than 800 mg per day) in patients with vitamin K deficiency, bleeding is possible. In sensitive patients, there is a risk of impaired metabolism of thyroid hormones, the likelihood of developing thromboembolism and thrombophlebitis increases.
If symptoms of an overdose appear, Vitamin E Zentiva is canceled, glucocorticosteroids are prescribed and symptomatic therapy is performed.
special instructions
In the case of taking vitamin E in high daily doses (more than 400 IU), the deficiency in the body of vitamin K may increase, which causes hypoprothrombinemia. In addition, the effect of simultaneously used anticoagulants is enhanced. In this regard, in order to avoid an overdose, you should not take any other drugs in combination, which contain alpha-tocopherol.
Patients with congenital epidermolysis bullosa are likely to grow white hair in areas affected by alopecia.
Influence on the ability to drive vehicles and complex mechanisms
Vitamin E Zentiva 100 mg, 200 mg and 400 mg does not affect a person's ability to drive vehicles and work with complex mechanisms.
Application during pregnancy and lactation
According to the instructions, Vitamin E Zentiva can be used during pregnancy and lactation, but only as directed by the attending physician.
Pediatric use
The drug is contraindicated in childhood.
Drug interactions
Vitamin E enhances the action of cardiac glycosides, non-steroidal anti-inflammatory drugs, glucocorticosteroids.
In patients with epilepsy, it increases the effect of antiepileptic drugs (if the content of lipid peroxidation products is increased in the blood).
In daily doses of more than 400 mg, Vitamin E Zentiva enhances the effect of anticoagulants (coumarin derivatives, indandione), increases the risk of bleeding and the development of hypoprothrombinemia.
Used in high doses, alpha-tocopherol may contribute to the development of vitamin A deficiency in the body.
The absorption of vitamin E is reduced with the simultaneous use of colestipol, cholestyramine and mineral oils.
In patients receiving iron supplements in high doses, oxidative processes in the body increase, therefore, the need for vitamin E increases.
To avoid overdose, it is not recommended to take other vitamin complexes containing alpha-tocopherol simultaneously with Vitamin E Zentiva.
Analogs
Analogues of Vitamin E Zentiva are: Alpha-Tocopherol-UBF, Alpha-tocopherol acetate, Alpha-tocopherol acetate (Vitamin E), Alpha-tocopherol acetate solution in oil (Vitamin E), Alpha-tocopherol acetate solution in oil 50% (Vitamin E), Vitrum Vitamin E, Doppelgerts Vitamin E forte.
Terms and conditions of storage
Shelf life - 3 years from the date of production, provided that the storage conditions recommended by the manufacturer are observed: protected from light, dry place out of the reach of children, temperature range - from 15 to 25 ° C.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews of Vitamin E Zentiva
Reviews of Vitamin E Zentiva are mostly positive. This drug is taken with vitamin deficiency, during stressful situations, with heavy physical exertion, to strengthen immunity in the autumn-winter period. Vitamin E is considered "the most feminine", therefore it is often prescribed for women with menstrual irregularities, during planning and during pregnancy.
According to reviews, alpha-tocopherol is a good antioxidant, prevents cell aging, protects red blood cells, prevents blood clots, regulates metabolic processes in the body, and also improves the condition of nails and hair.
Many women use these vitamins for cosmetic purposes, adding the oil contained in the capsules to creams, shampoos and masks.
The disadvantages of the drug, some patients attribute the danger of overdose, as well as the relatively high price.
Price for Vitamin E Zentiva in pharmacies
Approximate prices for Vitamin E Zentiva for a pack of 30 capsules, depending on their dosage:
- Vitamin E Zentiva 100 mg - 125-190 rubles;
- Vitamin E Zentiva 200 mg - 210-300 rubles;
- Vitamin E Zentiva 400 mg - 325-420 rubles.
Vitamin E Zentiva: prices in online pharmacies
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Drug name Price Pharmacy |
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Vitamin E Zentiva 100 mg capsule 30 pcs. RUB 137 Buy |
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Vitamin E Zentiva 400 mg capsule 30 pcs. 395 RUB Buy |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
