Vizomitin
Vizomitin: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Vizomitin
ATX code: S01XA
Active ingredient: plastoquinonyldecyltriphenylphosphonium bromide (plastohinonildetsiltriphenylphosphonium bromide)
Producer: Framon (Russia), Mitotech, LLC (Russia)
Description and photo update: 2019-19-08
Prices in pharmacies: from 409 rubles.
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Visomitin is an ophthalmic drug with keratoprotective and antioxidant effects.
Release form and composition
Dosage form - eye drops: slightly opalescent or transparent, slightly colored or colorless liquid (5 ml in polyethylene bottles with dropper stoppers and screw caps, 1 bottle in a cardboard box).
The components of the preparation:
- active: plastoquinonyldecyltriphenylphosphonium bromide (PDTP), in 1 ml - 0.155 μg;
- auxiliary: sodium hydrogen phosphate dodecahydrate, sodium chloride, hypromellose, sodium dihydrogen phosphate dihydrate, benzalkonium chloride, sodium hydroxide 1 M solution, water for injection.
Pharmacological properties
Pharmacodynamics
The active substance of Visomitin - PDTP (plastoquinonyldecyltriphenylphosphonium bromide), is a plastoquinone derivative, which is linked to the triphenylphosphine residue through a linker chain (C10). At nanomolar (low) concentrations, PDTP exhibits high antioxidant activity. In addition, it helps to increase the stability of the tear film and affects the processes of epithelialization and tear production.
One of the reasons for the development of age-related cataracts is the damaging effect of ultraviolet radiation, in which photo-oxidation processes are initiated, which leads to denaturation of the main structural component of the lens - crystallins.
The lacrimal fluid is the first protection of the eye tissue from ultraviolet radiation. It absorbs ultraviolet light (range - 240-320 nm) and, due to the components of antioxidant activity, contributes to its neutralization.
The anti-cataract effect, according to preclinical studies, is associated with an increase in the expression level of α-crystallins (the main lens proteins), restoration of the lens epithelium, and activation of energy processes in it. Against the background of age-related cataracts, due to the use of Visomitin, an increase in the antioxidant activity of tears is noted.
Pharmacokinetics
Studies of pharmacokinetic processes in humans have not been conducted.
When conducting preclinical studies on animals, it was found that after intragastric / intravenous administration in organs and tissues, the distribution of PDTP occurs within 48 hours. It was found that within one hour after application in the highest concentrations, PDTP is present in the tissues of the heart, liver and kidneys.
PDTP undergoes enzymatic degradation and covalent binding to proteins at a relatively high rate.
Indications for use
- dry eye syndrome;
- the initial stage of age-related cataract.
Contraindications
According to the instructions, Vizomitin should not be used in children and adolescents under the age of 18, as well as in patients with known hypersensitivity to any component of the drug.
Adequate controlled studies on the use of PDTP during pregnancy and lactation have not been conducted, therefore, women are not recommended to prescribe the drug during these periods. If it is necessary to carry out therapy during lactation, breastfeeding should be temporarily stopped.
Instructions for use of Vizomitin: method and dosage
Eye drops Visomitin should be dripped into the conjunctival sac.
Adult patients are prescribed 1-2 drops 3 times a day.
The duration of treatment for dry eye syndrome is determined individually, depending on the clinical situation.
Therapy for the initial stage of age-related cataract is 6 months.
Side effects
- from the senses: a short-term feeling of pain and burning in the eyes after instillation;
- others: allergic reactions.
Overdose
There is no information.
special instructions
During cataract treatment, the patient should be observed by an ophthalmologist, who will assess the degree of progression of the disease and decide whether to continue or discontinue conservative therapy.
Patients in whom, after instillation, the clarity of visual perception is disturbed, for some time after instillation, until vision is restored, should refrain from driving and performing potentially dangerous types of work.
Influence on the ability to drive vehicles and complex mechanisms
In cases where side effects occur after the use of Vizomitin in the form of short-term blurred vision, it is not recommended to drive vehicles until it is restored.
Application during pregnancy and lactation
Eye drops Visomitin during pregnancy / lactation are not prescribed (adequate controlled studies have not been conducted).
Pediatric use
Therapy with Visomitin is contraindicated in patients under 18 years of age.
Drug interactions
Visomitin can be used in combination with other ophthalmic drops, only you should maintain a minimum of 5-minute intervals between instillations.
Analogs
The analogues of Vizomitin are Vidisik, Aistil, Videstim, Gipromeloza-P, Lakropos, Defislez, Restasis, etc.
Terms and conditions of storage
Store at 2–8 ° С in a dark place. Keep out of the reach of children.
Shelf life is 2 years.
After opening, the bottle can be stored for no more than 1 month at a temperature of 2-8 ° C.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Vizomitin
Reviews about Vizomitin are different. Many people note its high efficiency, including with age-related cataracts. But in some cases, it is indicated that the drug does not have the claimed therapeutic effect, has a high cost and causes the development of adverse reactions.
Price for Visomitin in pharmacies
The approximate price for Visomitin eye drops 0.155 mcg / ml, for 1 bottle of 5 ml is 460-560 rubles.
Vizomitin: prices in online pharmacies
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Drug name Price Pharmacy |
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Visomitin 0.155 μg / ml eye drops 5 ml 1 pc. 409 r Buy |
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Visomitin eye drops 0.155 mcg / ml 5ml 572 r Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
