Benzydamine-Akrikhin
Benzydamine-Akrikhin: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Use in the elderly
- 12. Drug interactions
- 13. Analogs
- 14. Terms and conditions of storage
- 15. Terms of dispensing from pharmacies
- 16. Reviews
- 17. Price in pharmacies
Latin name: Benzydamine-Akrihin
ATX code: A01AD02
Active ingredient: benzydamine (Benzydamine)
Producer: Flumed-Farm KP, LLC (Republic of Moldova)
Description and photo update: 2020-11-06
Prices in pharmacies: from 207 rubles.
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Benzydamine-Akrikhin is a drug for local use in dentistry and ENT practice; has anti-inflammatory and analgesic effects.
Release form and composition
The preparation is produced in the form of a spray for topical application metered (0.255 mg / dose): a colorless transparent solution with a characteristic mint odor [30 ml (176 doses) in a dark glass bottle equipped with a dispensing device with a spray nozzle and a transparent cap; in a cardboard box 1 bottle and instructions for use of Benzidamine-Akrikhin].
100 ml of spray contains:
- active substance: benzydamine hydrochloride - 150 mg;
- additional components: sodium bicarbonate, glycerol, methyl parahydroxybenzoate, saccharin, polysorbate-20, peppermint leaf oil, ethanol 96%, purified water.
Pharmacological properties
Pharmacodynamics
Benzydamine is a non-steroidal anti-inflammatory drug (NSAID) that belongs to the indazole group. The drug demonstrates anti-inflammatory and local analgesic effects, exhibits antiseptic activity against a wide range of pathogenic microorganisms. The mechanism of action of the drug is based on the stabilization of cell membranes and inhibition of prostaglandin production.
The antibacterial and specific antimicrobial action of the drug is carried out through its rapid passage through the membranes of microorganisms and further damage to cellular structures, disruption of metabolic processes in the cell and its lysis.
The active substance demonstrates antimicrobial action against Candida albicans, provides structural modifications to metabolic chains and the walls of fungal cells, thereby preventing the reproduction of the latter. This property of Benzydamine-Akrikhin allows it to be used for the treatment of inflammatory processes in the oral cavity, including lesions of infectious etiology.
Pharmacokinetics
When used topically, benzydamine is actively absorbed through the mucous membranes and quickly penetrates into tissues prone to inflammation. In the blood plasma, the active substance is detected in an amount insufficient for the manifestation of systemic effects.
The agent is excreted in the form of conjugation products or inactive metabolites, mainly through the kidneys.
Indications for use
Benzydamine-Akrikhin is recommended for the symptomatic treatment of pain syndrome of inflammatory lesions of the ENT organs and oral cavity (of various etiologies):
- tonsillitis, laryngitis, pharyngitis;
- glossitis, gingivitis, stomatitis (including after radiation and chemotherapy);
- calculous inflammation of the salivary glands;
- candidiasis of the oral mucosa (as part of complex therapy);
- periodontal disease;
- conditions after treatment / tooth extraction;
- conditions after surgery and trauma, such as a fractured jaw, tonsillectomy.
In the presence of inflammatory / infectious diseases that require systemic therapy, Benzydamine-Akrikhin is used in combination with other drugs.
Contraindications
Absolute:
- age up to 3 years;
- pregnancy;
- period of breastfeeding;
- hypersensitivity to any component of the product.
Relative (requires treatment with the drug with extreme caution):
- bronchial asthma, including indications in the history (due to the increased risk of developing bronchospasm);
- hypersensitivity to other NSAIDs or acetylsalicylic acid.
Benzydamine-Akrikhin, instructions for use: method and dosage
Spray Benzydamine-Akrikhin should be applied topically after meals.
One dose of the drug (1 injection) contains benzydamine hydrochloride in an amount of 0.255 mg.
Recommended single doses of Benzydamine-Akrikhin, depending on the age of the patients, with the frequency of injections 2-6 times a day:
- children from 3 to 6 years: 1 injection for every 4 kg of body weight, the maximum single dose is 4 injections;
- children from 6 to 12 years old: 4 shots;
- adolescents over 12 years old and adults (including elderly patients): 4–8 injections.
The recommended dose cannot be exceeded, the course of therapy should not be more than 7 days. If, after the full course of treatment, there is no improvement or new symptoms develop, you should consult a specialist.
Side effects
- allergic reactions: infrequently (more than 1/1000, but less than 1/100) - photosensitization; rarely (more than 1/10 000, but less than 1/1000) - itching, skin rash, hypersensitivity reactions (it is required to cancel the spray treatment and carry out the appropriate therapy prescribed by the doctor); extremely rare (less than 1/10 000) - laryngospasm, angioedema; with an unknown frequency (the available data do not allow us to establish the incidence of adverse events) - anaphylactic reactions;
- local reactions: rarely - dryness, burning sensation in the mouth; with an unknown frequency - a feeling of numbness localized in the oral cavity.
In case of an increase in the severity of any of the above adverse events or the occurrence of other adverse reactions, you should consult a doctor.
Overdose
There are currently no reports of drug overdose cases. If the spray is used as directed, overdose is unlikely. In case of accidental oral administration of the drug, the following symptoms may develop: anxiety, abdominal cramps, vomiting, fever, fear, hallucinations, tachycardia, convulsions, ataxia, respiratory depression.
The antidote has not been established; in this condition, symptomatic treatment should be carried out. It is required to induce vomiting or, under the supervision of a specialist, rinse the stomach using a gastric tube, provide medical supervision, carry out adequate hydration and supportive therapy.
special instructions
If in patients with ulcers of the mucous membrane of the oropharynx symptoms do not relieve after treatment with the drug for more than 3 days, it is necessary to consult a doctor, since sometimes the presence of ulcers of this localization may indicate a serious pathology.
Spray Benzydamine-Akrikhin includes parahydroxybenzoates, which can lead to the development of allergic reactions.
Influence on the ability to drive vehicles and complex mechanisms
Benzydamine-Akrikhin does not adversely affect the ability to carry out potentially hazardous activities, including driving vehicles.
Application during pregnancy and lactation
The drug is not prescribed to pregnant and lactating women.
Pediatric use
In children under 3 years of age, the use of the spray is contraindicated, in children 3 years of age and older, it is possible according to the dosage regimen.
Use in the elderly
Elderly patients do not need a dose adjustment of Benzydamine-Akrikhin.
Drug interactions
There are no studies of the interaction of benzydamine with other medicinal substances / drugs.
Analogs
Analogs of Benzydamine-Akrikhin are Bronflex, Anidak, Anidak forte, Tantum Verde, Anidak sept, Benzidamine, Vertum ENT, Zvezdochka ENT, Tantum Verde forte, Oralsept, etc.
Terms and conditions of storage
Store in its original packaging out of the reach of children at a temperature not exceeding 25 ° C.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Benzidamine-Akrikhin
There are no reviews about Benzydamine-Akrikhin on specialized sites, as a result of this, it is impossible to really assess its effectiveness and disadvantages.
The price of Benzydamine-Akrikhin in pharmacies
The price of Benzydamine-Akrikhin in the form of a dosed topical spray (0.255 mg / dose) can be 210–230 rubles. per bottle of 30 ml.
Benzydamine-Akrikhin: prices in online pharmacies
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Drug name Price Pharmacy |
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Benzydamine-Akrihin spray for local. approx. dosage. 0.255mg / dose vial 30ml (176 doses) 207 r Buy |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
