Bacteriophage Klebsiella Polyvalent Purified

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Bacteriophage Klebsiella polyvalent purified: instructions for use and reviews

1. Release form and composition
2. Pharmacological properties
3. Indications for use
4. Contraindications
5. Method of application and dosage
6. Side effects
7. Overdose
8. Special instructions
9. Application during pregnancy and lactation
10. Use in childhood
11. Drug interactions
12. Analogs
13. Terms and conditions of storage
14. Terms of dispensing from pharmacies
15. Reviews
16. Price in pharmacies

Latin name: Klebsiella Polyvalent Bacteriophage Purified

ATX code: V03A

Active ingredient: Klebsiella bacteriophage (Klebsiella bacteriophage)

Manufacturer: Microgen NPO FGUP MZ RF (Russia)

Description and photo updated: 2018-29-11

Prices in pharmacies: from 710 rubles.

Buy

Solution for oral administration, local and external use Bacteriophage Klebsiella polyvalent purified

Purified polyvalent bacteriophage Klebsiella - medical immunobiological preparation - bacteriophage (MIBP bacteriophage) with immunostimulating action.

Release form and composition

The drug is available in the form of a solution for oral administration, local and external use: transparent liquid from light yellow to dark yellow, green tint is allowed (10 ml or 20 ml in glass bottles, in a cardboard box 4 or 10 bottles; 4 a bottle in a blister strip, in a cardboard box 1 package and instructions for use of Bacteriophage Klebsiella polyvalent purified).

1 bottle contains:

active substance: Klebsiella bacteriophage - a sterile mixture of purified filtrates of phagolysates of bacteria Klebsiella ozaenae, Klebsiella pneumoniae, Klebsiella rhinoscleromatis;
excipient: preservative - 8-hydroxyquinoline sulfate monohydrate.

Pharmacological properties

Biological properties of the Bacteriophage Klebsiella polyvalent purified are the ability to cause specific lysis of bacteria Klebsiella pneumoniae, Klebsiella rhinoscleromatis, Klebsiella ozaenae.

Indications for use

The use of Bacteriophage Klebsiella polyvalent purified is indicated as part of complex therapy for the prevention or treatment of the following diseases caused by the bacteria Klebsiella ozaenae, Klebsiella pneumoniae, Klebsiella rhinoscleromatis:

diseases of the gastrointestinal tract (GIT) - intestinal dysbiosis, gastroenterocolitis, pancreatitis, cholecystitis;
infections resulting from surgical operations - purulent skin lesions, suppuration of wounds, peritonitis, pleurisy, osteomyelitis, abscess;
urinary tract infections - cystitis, pyelonephritis, endometritis, urethritis, vulvitis, colpitis, salpingo-oophoritis, bartholinitis;
scleroma, ozena;
purulent-inflammatory pathologies of the oral cavity, throat, pharynx, larynx, bronchi, lungs, pleura, nose, sinuses, ear - stomatitis, periodontitis, tonsillitis, pharyngitis, laryngitis, bronchitis, frontal sinusitis, pneumonia, pleurisy, sinusitis, otitis media;
infections of the organ of vision - keratoconjunctivitis, post-traumatic conjunctivitis, purulent corneal ulcer, iridocyclitis;
burns of various origins;
mastitis;
nosocomial infections caused by Klebsiella (for the purpose of prevention).

In young children, including newborns, the drug is used for the treatment and prevention of the following inflammatory diseases - intestinal dysbiosis, omphalitis, gastroenterocolitis, pemphigus, pyoderma, septicopyemia of various localization, septicemia.

The use of MIBP-bacteriophage should be started after the test for the sensitivity of the infection to phage therapy.

Contraindications

The use of a solution of Bacteriophage Klebsiella polyvalent purified in patients with established individual intolerance to its components is contraindicated.

Bacteriophage Klebsiella polyvalent purified, instructions for use: method and dosage

Bacteriophage Klebsiella polyvalent purified is used orally (0.5-1 hour before meals), in the form of enemas, irrigation, applications, by insertion into the vagina, in the cavity of wounds, uterus, nose and nasal sinuses, in the drainage cavity of abscesses, bladder and renal pelvis, in the abdominal and pleural cavities.

Before use, the contents of the vial must be shaken, if the solution turns out to be cloudy or a precipitate is found in it, then the bacteriophage must not be used!

To prevent bacteria from entering the vial from the environment, the vial should be opened observing the following standards of sterility: wash your hands thoroughly, treat the metal cap with a swab soaked in alcohol. After removing the cap, do not open the cap immediately. Do not allow the inner surface of the cork to come into contact with any objects. It is strictly not allowed to leave the bottle open. After opening, it must be stored in the refrigerator. The selection of small doses (2–8 drops) of the drug should be done with a sterile syringe.

Compliance with the above recommendations for using the drug from an opened bottle and the absence of turbidity of the solution allows its use throughout the entire shelf life.

The recommended single dose when taking Bacteriophage Klebsiella polyvalent purified by mouth or in the form of an enema, taking into account the patient's age:

0–0.5 years: 10 ml;
0.5–1 years: inside - 10 ml, in the form of an enema - 20 ml;
1-3 years: inside - 15 ml, in the form of an enema - 20-30 ml;
3–8 years: inside - 20 ml, in the form of an enema - 30–40 ml;
8 years and older: inside - 20-30 ml, in the form of an enema - 40-50 ml.

In case of local purulent-inflammatory diseases, treatment should include taking the drug inside and applying it to the site of the lesion.

With the simultaneous use of chemical antiseptics to treat the cavity of a purulent focus, before using the bacteriophage, it should be washed with a sterile 0.9% sodium chloride solution.

Recommendations for the use of Bacteriophage Klebsiella polyvalent purified, depending on the disease:

ozena, scleroma: in the form of washing the nasal cavity and the mucous membrane of the upper respiratory tract - 10–20 ml 2-3 times a day. According to clinical indications, the drug is injected into the cavity of the sinuses. In case of damage to the pharynx, larynx, trachea, the solution is used in the form of inhalations without the use of ultrasound and heating. After washing the nasal cavity, turundas soaked in bacteriophage are injected into each nasal passage in turn, and left for 1 hour. Duration of the course is 20–40 days;
angina, pharyngitis, laryngitis: in the form of rinsing the mouth and pharynx - 10–20 ml 3 times a day for 7–10 days;
bronchitis, pneumonia: inside - 10–20 ml 3 times a day, additionally in the form of aerosols and inhalations (without heating and using ultrasound), the course of treatment is 15–20 days;
otitis media: by introducing and rinsing the middle ear cavity - 2-5 ml 1-3 times a day for 7-15 days;
inflammation of the sinuses: for rinsing the nasal cavity, nasopharynx and nasal sinuses - 5-10 ml, for injection into the sinuses - 2-3 ml each. The procedure is carried out once a day for 7-10 days. In addition, it is shown the introduction in turn into each nasal passage of turunda soaked in solution for 0.5-1 hour 3 times a day for 7 to 15 days;
stomatitis, chronic periodontitis: in the form of mouth rinses - 10–20 ml 3-4 times a day; introduction of turunda impregnated with bacteriophage into periodontal pockets for 10 minutes, the course of treatment is 7-10 days;
conjunctivitis, keratoconjunctivitis: 2-3 drops 4-5 times a day; the duration of the course of treatment is 5-7 days;
purulent corneal ulcer: 4–5 drops a day for 7–10 days;
purulent iridocyclitis: topically - 6-8 drops at intervals of 3 hours, inside - in therapeutic doses, taking into account the patient's age; the duration of the course is 7-10 days;
abscess: the solution is injected into the cavity formed after the opening and removal of the purulent contents in a smaller volume of removed pus - once a day, daily for 7-10 days;
peritonitis, pleurisy: injected through drainage tubes into the drained abdominal or pleural cavity - 20–70 ml once a day; the duration of the course of treatment is 10-15 days;
osteomyelitis: injected into the wound cavity through drains, turundas - 10-30 ml once a day for 15-20 days;
suppuration of wounds: in the form of irrigation, introduction into the drainage, applications, dressings - 5–50 ml each, depending on the size of the lesion, at least 1 time per day. The course of therapy is 10-15 days;
purulent-inflammatory gynecological pathologies (suppuration of wounds, endometritis, vulvitis, salpingo-oophoritis, bartholinitis, colpitis): in the form of irrigation, applications, introduction into the cavity of the wound, vagina, uterus - 5–20 ml once a day for 7–10 days;
cystitis, pyelonephritis, urethritis: inside - in a therapeutic dose 1 hour before meals 3 times a day for 10-20 days. When draining the bladder cavity or the renal pelvis, the solution is injected through the cystostomy or nephrostomy - 20-50 ml into the bladder and 5-7 ml into the renal pelvis. Frequency rate of procedures 1-3 times a day for 7-15 days;
intestinal dysbiosis, gastroenterocolitis, cholecystitis, pancreatitis: inside - in age-specific dosages 1 hour before meals 3 times a day. The duration of the course, taking into account clinical indications, can vary from 7 to 15 days. In case of indomitable vomiting, the use of the drug in the form of high enemas is indicated - 20-40 ml 2-3 times a day. For the treatment of intestinal dysbiosis, the simultaneous use of drugs of normal flora is shown;
prevention of nosocomial surgical infections: in the form of treatment of postoperative and freshly infected wounds - 5–50 ml, depending on the size of the lesion, once a day for 5–7 days.

Recommendations for the use of Bacteriophage Klebsiella polyvalent purified for the treatment of children under 1 year of age, including premature infants:

gastroenterocolitis, pneumonia, sepsis of newborns: orally - 3-5 ml 0.5 hours before feeding 2-3 times a day. In case of indomitable vomiting, the solution is injected rectally (using high enemas through a catheter or gas tube) - 5-10 ml once a day. If necessary, a combination of rectal and oral administration of the drug is possible. The duration of the course of treatment is determined individually, taking into account clinical indications, it can be from 7 to 15 days. In case of relapse, the course of treatment can be repeated;
omphalitis, pyoderma, infected wounds: in the form of applications of a gauze napkin soaked in bacteriophage on the umbilical wound or the affected area of the skin - 5-10 ml 2-3 times a day for 7-15 days;
prevention of nosocomial infection in newborns: inside according to epidemic indications - 3-5 ml 0.5 hours before feeding 3 times a day during the entire period of hospital stay.

Side effects

The undesirable side effects of the bacteriophage have not been established.

Overdose

Overdose symptoms have not been established.

special instructions

Considering the chronic nature of ozena and scleroma, for the prevention of exacerbations, it is recommended to use the bacteriophage once a year.

During transportation, the storage temperature is allowed from 9 to 25 ° C for no more than 1 month.

Influence on the ability to drive vehicles and complex mechanisms

Bacteriophage Klebsiella polyvalent purified does not affect the patient's ability to drive vehicles and mechanisms.

Application during pregnancy and lactation

The use of this bacteriophage during gestation and breastfeeding is possible according to the doctor's prescription according to clinical indications.

Pediatric use

The use of Bacteriophage Klebsiella polyvalent purified is indicated for the treatment of children from birth according to clinical indications in compliance with the recommendations for dosing of the drug.

Drug interactions

The solution is used as part of a complex therapy, including other antibacterial and anti-inflammatory drugs.

Analogs

The analogues of the Bacteriophage Klebsiella polyvalent purified are Bacteriophage Klebsiella, Intesti-bacteriophage, Bacteriophage coli, Pyobacteriophage, Bacteriophage Klebsiella pneumonia, Bacteriophage staphylococcus, etc.

Terms and conditions of storage

Keep out of the reach of children.

Store between 2 and 8 ° C.

The shelf life is 24 months.

Terms of dispensing from pharmacies

Available without a prescription.

Reviews of Bacteriophage Klebsiella polyvalent purified

Reviews about Bacteriophage Klebsiella polyvalent purified are positive. Along with the effectiveness of the drug, its advantages include the absence of undesirable phenomena and age restrictions, a targeted effect on a certain type of bacteria, and a wide range of indications for use.

Price for Bacteriophage Klebsiella polyvalent purified in pharmacies

The price for Bacteriophage Klebsiella polyvalent purified for a package containing 4 vials of 20 ml can range from 691–778 rubles.

Purified polyvalent bacteriophage Klebsiella: prices in online pharmacies

Drug name

Price

Pharmacy

Bacteriophage Klebsiella polyvalent purified solution for internal and external use 20 ml 4 pcs.

710 RUB

Buy

Anna Kozlova Medical journalist About the author

Education: Rostov State Medical University, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!