Penzital
Penzital: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Penzital
ATX code: A09AA02
Active ingredient: Pancreatin (Pancreatin)
Manufacturer: Shreya Life Science Pvt. Ltd., India
Description and photo update: 2019-09-08
Prices in pharmacies: from 42 rubles.
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Penzital is an enzyme remedy that compensates for the insufficiency of the exocrine function of the pancreas.
Release form and composition
Dosage form - enteric film coated tablets: round, convex on both sides, white (10 pcs. In strips, in a cardboard box from 1 to 12 strips).
The active ingredient of the drug is pancreatin, its content in 1 tablet is 212.5 mg, which corresponds to the enzymatic activity:
- Lipase - 6000 U FIP;
- Amylase - 4500 U FIP;
- Proteases - 300 U FIP.
Additional components: sodium starch glycolate, microcrystalline cellulose, povidone, titanium dioxide, methacrylic acid copolymer, colloidal silicon dioxide, diethyl phthalate, talc, lactose.
Pharmacological properties
Pharmacodynamics and pharmacokinetics
Penzital is used to compensate for the insufficiency of the external secretory function in the pancreas. The drug has proteolytic, lipolytic and amylolytic effects on the body.
The enzymes included in pancreatin (alpha-amylase, lipase, trypsin, chymotrypsin) take part in the breakdown of fats to glycerol and fatty acids, proteins to amino acids, starch to dextrins and monosaccharides, and also contribute to the normalization of digestive processes and improve the functional state of the gastrointestinal tract. …
Trypsin inhibits the stimulated secretion of the pancreas, having an analgesic effect.
The release of pancreatic enzymes from the dosage form occurs in the alkaline medium of the small intestine, since the drug is protected from the influence of gastric juice by the membrane. The maximum enzymatic activity after oral administration is observed 30–45 minutes after the drug is administered. Pancreatin is not absorbed in the gastrointestinal tract and is excreted along with the feces.
Indications for use
Indications for Penzital:
- Disturbances in the assimilation of food (including in conditions after resection of the stomach or small intestine);
- Exocrine pancreatic insufficiency (diarrhea of non-infectious origin, flatulence, dyspepsia, cystic fibrosis, gastrocardial syndrome, chronic pancreatitis, conditions after irradiation and pancreatectomy) - as replacement therapy;
- Prolonged immobilization, impaired chewing function, inaccuracies in nutrition (irregular eating, eating fatty foods, eating large amounts of food) in people with a normally functioning gastrointestinal tract - to improve food digestion;
- Examination (ultrasound or X-ray) of the abdominal cavity - to prepare the organs of the gastrointestinal tract.
Contraindications
Absolute:
- Exacerbation of chronic pancreatitis;
- Acute pancreatitis;
- Hypersensitivity to drug components.
Instructions for the use of Penzital: method and dosage
The tablets should be taken orally during meals or immediately after meals: swallow whole and drink plenty of non-alkaline liquid (water or fruit juice).
The doctor determines the dose for each patient individually, depending on the degree of digestive disorders.
Adults are usually prescribed 1-2 tablets 3 times a day.
The duration of treatment is also set on a private basis, it can vary from a few days (with inaccuracies in nutrition) to several months or even years (with constant substitution therapy).
Side effects
- On the part of the digestive system: nausea, constipation / diarrhea, a feeling of discomfort in the stomach (however, the causal relationship of the development of these effects with the use of Penzital has not been proven, since these reactions are also symptoms of exocrine pancreatic insufficiency);
- From the side of metabolism: with prolonged use of the drug in high doses - hyperuricosuria, hyperuricemia;
- Others: allergic reactions.
In patients with cystic fibrosis, if the recommended doses are exceeded, fibrous colonopathy (strictures) may develop in the ileocecal part of the ascending colon.
In children, when taking high doses of pancreatin, irritation of the oral mucosa and the development of perianal irritation is possible.
Overdose
In case of an overdose, constipation (mainly in children), hyperuricemia, hyperuricosuria may occur. In difficult cases of overdose, the drug is canceled, the stomach and intestines are washed, and symptomatic treatment is prescribed.
special instructions
The prescribed dose of the drug should correspond to the amount of enzymes required to ensure fat absorption. In this case, the quality and quantity of food consumed must be taken into account.
When carrying out long-term therapy, it is recommended to take iron supplements at the same time.
Patients with cystic fibrosis are at risk of developing fibrous colonopathy, therefore they are not recommended to use Penzital in high doses.
Application during pregnancy and lactation
There are no reliable data indicating the safety of using pancreatin during pregnancy. Experimental studies have shown that pancreatin has no teratogenic effect.
Treatment of pregnant women with Penzital according to indications is possible only in cases where the benefits to the mother outweigh the possible harm to the child.
Pediatric use
When treating children, the drug is used according to the dosage regimen. The high activity of lipase contained in pancreatin increases the risk of constipation in children.
Drug interactions
Antacids containing magnesium hydroxide and / or calcium carbonate reduce the effectiveness of pancreatin.
According to the instructions, Penzital can reduce the absorption of iron preparations.
Analogs
Penzital's analogs are: Gastenorm Forte, Pancreatin, Pancreatin-LekT, Pancreatin forte, Mezim, Mezim Forte, Panzinorm, Panzinorm Forte, Creon, Pangrol, Ermital, Micrasim, PanziKam, Panzim forte, Pancreazim, Pensital-Pensital.
Terms and conditions of storage
Store at a temperature of 2-25 ºС in a dry place out of reach of children.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Penzital
Positive feedback about Penzital is left not only by patients with various diseases of the gastrointestinal tract, but also by people who need medication for overeating.
This drug is often used by pregnant women after meals to relieve nausea or a feeling of heaviness in the stomach. Also, representatives of this group take Penzital to improve digestion and normalize the digestive tract.
Price for Penzital in pharmacies
The price of Penzital is from 55 to 60 rubles for a pack of 20 tablets.
Penzital: prices in online pharmacies
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Drug name Price Pharmacy |
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Penzital enteric-coated tablets 20 pcs. RUB 42 Buy |
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Penzital tablets p.p. enteric solution. 20 pcs. 52 RUB Buy |
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Penzital enteric-coated tablets 80 pcs. 142 RUB Buy |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
