Atropine
Instructions for use:
- 1. Release form and composition
- 2. Indications for use
- 3. Contraindications
- 4. Method of application and dosage
- 5. Side effects
- 6. Special instructions
- 7. Analogs
- 8. Terms and conditions of storage
Prices in online pharmacies:
from 12 rubles.
Buy
Atropine is an anticholinergic drug, blocker of m-cholinergic receptors.
Release form and composition
Atropine is available in the following forms:
- Solution for injection containing 1 mg of atropine sulfate in 1 ml (in 1 ml ampoules);
- Eye drops 1% containing 10 mg of atropine sulfate in 1 ml (in 5 ml polyethylene dropper bottles).
Indications for use
Atropine is an anticholinergic and antispasmodic agent. Its active substance is a poisonous alkaloid, which is found in the leaves and seeds of plants of the Solanaceae family, such as henbane, belladonna, and dope. The main chemical feature of the drug is its ability to block the m-cholinergic systems of the body, which are located in the heart muscle, organs with smooth muscles, the central nervous system and secretory glands.
The use of Atropine helps to reduce the secretory function of the glands, relax the tone of smooth muscle organs, dilate the pupil, increase intraocular pressure and paralysis of accommodation (the ability of the eye to change the focal length). The acceleration and excitement of cardiac activity after the use of the drug is explained by its ability to remove the inhibitory effects of the vagus nerve. The effect of the drug on the central nervous system occurs in the form of stimulation of the respiratory center, and when toxic doses are used, motor and mental excitement (convulsions, visual hallucinations) is possible.
Atropine is prescribed:
- Peptic ulcer and 12 duodenal ulcer;
- Spasms of the bile ducts, smooth muscle organs of the gastrointestinal tract, bronchi;
- Hypersalivation (parkinsonism, poisoning with salts of heavy metals, dental interventions);
- Bradycardia;
- Acute pancreatitis;
- Intestinal and renal colic;
- Irritable bowel syndrome;
- Bronchospasm;
- Bronchitis with hypersecretion;
- AV block;
- Laryngospasm;
- Poisoning with anticholinesterase substances and m-cholinomimetics.
Also, Atropine is used in X-ray studies of the gastrointestinal tract, for premedication before surgery and in ophthalmology (to dilate the pupil and achieve accommodation paralysis in order to determine the true refraction of the eye, study the fundus, treat spasm of the central retinal artery, keratitis, iritis, choroiditis, iridocyclitis, embolism and some eye injuries).
Contraindications
The use of Atropine is contraindicated in case of hypersensitivity to the components of the drug.
Method of administration and dosage
Injection
Depending on the indications, Atropine is administered subcutaneously, intramuscularly or intravenously at 0.25-1 mg, the frequency of use is up to 2 times a day.
To eliminate bradycardia, adults are injected intravenously with 0.5-1 mg, if necessary, after 5 minutes, the drug is repeated. Children's dosage is determined by body weight - 0.01 mg / kg.
For premedication, Atropine is administered intramuscularly 45-60 minutes before anesthesia:
- Adults - 0.4-0.6 mg each;
- Children - 0.01 mg / kg.
Eye drops
When using Atropine in ophthalmology, 1-2 drops of a 1% solution are instilled into the sore eye, the frequency of use (determined by the indications) is up to 3 times a day, observing an interval of 5-6 hours. In some cases, it is possible to introduce a 0.1% solution:
- Subconjunctival - 0.2-0.5 ml;
- Parabulbar - 0.3-0.5 ml each.
For electrophoresis, 0.5% Atropine solution is injected from the anode through the eyelids.
Side effects
With systemic use of Atropine, the following can develop:
- Tachycardia;
- Dry mouth;
- Difficulty urinating;
- Dizziness;
- Constipation;
- Photophobia;
- Mydriasis;
- Accommodation paralysis;
- Impairment of tactile perception.
When using Atropine in the treatment of eye diseases, in some cases, there may be:
- Conjunctival edema and hyperemia of the eyeball and eyelids;
- Hyperemia of the skin of the eyelids;
- Dry mouth;
- Photophobia;
- Tachycardia.
special instructions
Atropine should be used with caution in diseases of the cardiovascular system, in which an increase in heart rate is undesirable:
- Tachycardia;
- Atrial fibrillation;
- Cardiac ischemia;
- Chronic heart failure;
- Arterial hypertension;
- Mitral stenosis.
Also, Atropine must be used with caution in thyrotoxicosis, acute bleeding, reflux esophagitis, elevated body temperature, increased intraocular pressure, diseases of the gastrointestinal tract, accompanied by obstruction, gestosis, dry mouth, ulcerative colitis, chronic lung diseases, hepatic and renal insufficiency, hypertrophy of the prostate gland without obstruction of the urinary tract, myasthenia gravis, cerebral palsy, brain damage in children, Down's disease.
An interval of at least 1 hour should be observed between the use of antacids and Atropine.
With parabulbar or subconjunctival administration of the drug in order to reduce tachycardia, the patient should be given a validol tablet under the tongue.
During the period of treatment with Atropine, caution should be exercised when engaging in potentially hazardous activities and when driving.
Analogs
By the mechanism of action, analogues of Atropine are: Bellacehol, Appamid Plus, Cyclomed, Tropicamide, Hyoscyamine, Midriacil, Cycloptic, Midrimax, Bekarbon.
Terms and conditions of storage
The drug is dispensed by prescription. The shelf life of Atropine at temperatures up to 25 ° C is:
- Solution for injection - 5 years;
- Eye drops - 3 years.
Atropine: prices in online pharmacies
|
Drug name Price Pharmacy |
|
Atropine 1 mg / ml injection 1 ml 5 pcs. RUB 12 Buy |
|
Atropine (eye drops) 1% eye drops 5 ml 1 pc. RUB 47 Buy |
|
Atropine eye drops 1% 5ml RUB 60 Buy |
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
