Aspirin Express
Aspirin Express: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Use in the elderly
- 14. Drug interactions
- 15. Analogs
- 16. Terms and conditions of storage
- 17. Terms of dispensing from pharmacies
- 18. Reviews
- 19. Price in pharmacies
Latin name: Aspirin Express
ATX code: N02BA
Active ingredient: acetylsalicylic acid (Acetylsalicylic acid)
Manufacturer: Bayer Bitterfeld, GmbH (Germany)
Description and photo update: 2020-28-05
Prices in pharmacies: from 279 rubles.
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Aspirin Express is a non-steroidal anti-inflammatory drug (NSAID) with analgesic, antipyretic and anti-inflammatory effects.
Release form and composition
Dosage form - effervescent tablets: white, flat, round, slightly beveled to the edge, branded engraving in the form of a Bayer cross on one side (in paper strips laminated with aluminum foil, 2 pcs., In cardboard boxes along with instructions for use Aspirin Express 6 or 12 strips).
Composition of 1 effervescent tablet:
- active ingredient: acetylsalicylic acid - 500 mg;
- additional substances: monosodium carbonate, anhydrous sodium carbonate, anhydrous sodium citrate, anhydrous citric acid.
Pharmacological properties
Pharmacodynamics
Acetylsalicylic acid is an NSAID with analgesic, antipyretic and anti-inflammatory properties. The mechanism of action lies in the irreversible inhibition of the enzyme cyclooxygenase (COX), which regulates the synthesis of thromboxane A2, as well as prostaglandins E12 and E2.
Pharmacokinetics
Acetylsalicylic acid is highly absorbed; after oral administration, it is rapidly absorbed from the gastrointestinal tract (GIT) in full. The maximum concentration (C max) of the substance in the blood plasma when ingested Aspirin Express effervescent tablets is achieved after 18 minutes, which is 2 times faster than standard tablets, when taken, C max is fixed after 30–45 minutes. During and immediately after absorption, acetylsalicylic acid is converted into salicylic acid, the main metabolite with pharmacological activity. The C max of this metabolite in blood plasma for a dosage form in the form of effervescent tablets is reached after 48 minutes, while the same indicator for standard tablets is 1.5–2 hours.
The connection with plasma proteins of acetylsalicylic acid and its metabolite is approximately 80%, distribution in tissues is rapid. Salicylic acid is metabolized in the liver, resulting in the formation of the following metabolites: salicilurate, salicylophenolic glucuronide, salicylacyl glucuronide, gentisuric and gentisic acids.
Penetrates through the placenta, is found in breast milk.
The elimination of salicylic acid from the body depends on the doses of Aspirin Express taken. The period of excretion varies from 2–3 hours with low doses to about 15 hours with high doses of the drug. Salicylic acid and its metabolites are excreted mainly in the urine.
Indications for use
Aspirin Express is used as an antipyretic agent for colds and other infectious and inflammatory diseases, as well as an analgesic agent for relieving sore throat, toothache and headache, back pain, joints, muscles, menstrual pain, mild arthritis pain, etc. P.
Contraindications
Absolute:
- severe heart failure in the stage of decompensation;
- severe renal / hepatic impairment;
- hemorrhagic diathesis;
- ulcerative lesion of the gastrointestinal tract;
- bronchial asthma induced by taking NSAIDs and salicylates;
- I and III trimesters of pregnancy;
- lactation period;
- simultaneous reception with methotrexate at a dose of 15 mg per week;
- hypersensitivity to acetylsalicylic acid and other salicylates or auxiliary components that make up Aspirin Express.
In addition, the drug should not be prescribed to children under 15 years of age with acute respiratory diseases caused by viral infections, as this increases their risk of developing encephalopathy and acute fatty liver disease with acute development of liver failure (Reye's syndrome).
Relative (Aspirin Express tablets are taken, taking precautions):
- impaired renal / liver function;
- hyperuricemia;
- gout;
- II trimester of pregnancy;
- simultaneous therapy with anticoagulants;
- a history of indications of gastrointestinal ulcers (including chronic or recurrent peptic ulcer disease), bleeding from the gastrointestinal tract, bronchial asthma, hay fever, nasal polyposis, chronic respiratory diseases, allergic reactions to NSAIDs and other drugs.
Aspirin Express, instructions for use: method and dosage
Aspirin Express effervescent tablets are taken orally after meals, after dissolving them in a glass of water.
For febrile conditions and pain syndrome of mild / moderate intensity, a single dose for adults and children over 15 years old - 2 effervescent tablets (1000 mg of acetylsalicylic acid).
The maximum single dose that should not be exceeded is 2 effervescent tablets (1000 mg of acetylsalicylic acid). A maximum of 6 effervescent tablets (3000 mg of acetylsalicylic acid) can be taken per day. At least 4-hour intervals must be observed between doses.
It is allowed to carry out therapy independently (without consulting a doctor) for no more than 7 days when taking Aspirin Express as an anesthetic and for no more than 3 days as an antipyretic agent.
Side effects
Possible adverse reactions when taking acetylsalicylic acid:
- from the digestive system: heartburn, nausea, vomiting, abdominal pain, stomach and duodenal ulcers (including perforated), bleeding from the gastrointestinal tract (including latent, which can lead to the development of iron deficiency anemia), increased activity of hepatic transaminases;
- on the part of the hematopoietic system: lengthening of the bleeding time with the development of bleeding of various localization (bleeding from the gums, epistaxis, hemorrhagic purpura, etc.);
- from the central nervous system and sensory organs: hearing impairment, tinnitus, dizziness, headache (as a rule, they are signs of an overdose);
- allergic reactions: urticaria and other skin manifestations of hypersensitivity, Quincke's edema, bronchial asthma, anaphylactic reactions.
Overdose
Overdose of Aspirin Express is especially dangerous for elderly patients and young children, in whom excessive intake of acetylsalicylic acid can be fatal.
Overdose symptoms:
- moderate degree: lethargy, dizziness, a feeling of hearing loss, tinnitus, headache (symptoms can be controlled by reducing the dose of the drug);
- severe: ketosis, hyperventilation, fever, metabolic acidosis, respiratory alkalosis, coma, respiratory failure, cardiovascular shock, severe hypoglycemia.
As measures of emergency care, it is necessary to urgently hospitalize the victim in a specialized department for emergency therapy: perform gastric lavage, give the patient activated charcoal, determine the acid-base balance, carry out alkaline diuresis until urine pH values are within 7.5-8 alkaline diuresis with a concentration of salicylates in the blood of more than 300 mg / l (2.2 mmol / l) in children and 500 mg / l (3.6 mmol / l) in adults, compensate for fluid loss, if necessary, prescribe symptomatic treatment.
When diagnosing severe poisoning, hemodialysis is possible.
special instructions
In pediatrics, drugs containing acetylsalicylic acid are not prescribed, since when treating a viral infection in children, they increase their risk of developing Reye's syndrome, manifested by prolonged vomiting, acute encephalopathy, and enlarged liver.
Acetylsalicylic acid can cause bronchospasm and lead to an attack of bronchial asthma or other allergic reactions. Particularly susceptible to the development of this condition are patients who have such risk factors as a history of bronchial asthma, hay fever, nasal polyposis, chronic respiratory diseases, as well as allergic reactions to other drugs (for example, urticaria, itching and other skin reactions) …
Because Aspirin Express is able to inhibit platelet aggregation, it can cause increased bleeding during and after surgical procedures, including tooth extraction and other minor surgical procedures. The risk of bleeding increases with high doses of acetylsalicylic acid. Preservation of the hemorrhagic effect is observed for 4-8 days after its cancellation.
Acetylsalicylic acid, taken in low doses, reduces the excretion of uric acid, which can lead to the development of gout in patients with an initially low level of its excretion.
With prolonged use of analgesics, addiction headaches are likely to occur, which occurs if they are canceled.
The habitual use of analgesics, especially their various combinations, can provoke the development of analgesic nephropathy (severe kidney damage).
One dose of Aspirin Express contains 1086 mg of sodium, which is important to consider for patients who are on a diet that prescribes to limit salt intake.
Influence on the ability to drive vehicles and complex mechanisms
The use of Aspirin Express does not affect the psychophysiological parameters of a person - the speed of reaction and the ability to concentrate.
Application during pregnancy and lactation
The use of drugs containing acetylsalicylic acid in their composition is prohibited in the first and third trimesters of pregnancy. In the second trimester of pregnancy, the occasional appointment of such funds is allowed. It is not allowed to be used as a drug for long-term therapy.
The use of acetylsalicylic acid (as well as other inhibitors of prostaglandins) in a dose of more than 500 mg per day in the third trimester of pregnancy can cause fetal abnormalities, namely renal dysfunction up to the development of renal failure with oligohydramnios and cardiopulmonary disorders such as pulmonary hypertension and premature closure of the arterial duct. In addition, there is a high risk of lengthening the bleeding time in the mother and fetus towards the end of pregnancy. This effect can be observed even when taking acetylsalicylic acid in small doses.
When breastfeeding a child, the use of drugs containing acetylsalicylic acid is contraindicated, since salicylates and their metabolites penetrate into breast milk in small quantities.
Pediatric use
Aspirin Express should not be prescribed to children under 15 years of age with acute respiratory diseases caused by viral infections, as this increases their risk of developing encephalopathy and acute fatty liver disease with acute development of liver failure (Reye's syndrome).
With impaired renal function
Severe renal failure is an absolute contraindication to the use of Aspirin Express tablets.
In case of impaired renal function, the drug is used with caution.
For violations of liver function
Severe liver failure is an absolute contraindication to the use of Aspirin Express.
In case of violations of liver function, the drug is used with caution.
Use in the elderly
For elderly patients, there are no special instructions for the use of Aspirin Express.
Drug interactions
- methotrexate: a combination with methotrexate at a dose of more than 15 mg per week is contraindicated, when using a dose of less than 15 mg per week, it is used with caution. This is due to an increase in the hematological toxicity of methotrexate when used in combination with acetylsalicylic acid, since NSAIDs generally decrease the renal clearance of methotrexate, and salicylates, in particular, displace it from its connection with plasma proteins;
- heparin, coumarin and other anticoagulants: when these drugs are taken in combination with acetylsalicylic acid, oral anticoagulants are displaced from their connection with plasma proteins, and the risk of bleeding increases due to suppression of platelet function, damage to the gastric mucosa and duodenal ulcer;
- other NSAIDs with salicylates, taken in high doses (over 3000 mg per day): due to synergism, the risk of ulceration of the gastrointestinal mucosa and bleeding increases;
- probenecid, benzbromarone and other uricosuric drugs: due to the competitive tubular excretion of uric acid, their therapeutic effect is reduced;
- digoxin: due to a decrease in the excretion of digoxin, its concentration in plasma increases;
- sulfonylurea, insulin and other antidiabetic drugs: acetylsalicylic acid in high doses has a hypoglycemic effect and displaces sulfonylurea from its connection with plasma proteins, in connection with which the hypoglycemic effect is enhanced;
- ticlopidine and other antiplatelet drugs of other classes, thrombolytics: the risk of bleeding increases;
- diuretics: in combination with acetylsalicylic acid at a dose of 3000 mg per day, due to a decrease in the synthesis of prostaglandins in the kidneys, there is a decrease in glomerular filtration;
- systemic glucocorticosteroids (GCS), except for hydrocortisone (used in the treatment of Addison's disease): when used simultaneously with acetylsalicylic acid, the content of salicylates in the blood decreases, since GCS enhances their elimination;
- angiotensin-converting enzyme (ACE) inhibitors: with the combined use of acetylsalicylic acid at a dose of 3000 mg per day or more, and ACE inhibitors, a decrease in the hypotensive effect of the latter was noted due to a decrease in glomerular filtration;
- valproic acid: acetylsalicylic acid breaks the bond of valproic acid with plasma proteins, and therefore the toxicity of the latter increases;
- ethanol: the use of ethanol-containing agents while taking Aspirin Express lengthens the bleeding time and enhances the damaging effect on the gastrointestinal mucosa.
Analogs
Analogues of Aspirin Express are Acecardol, ASK-cardio, Aspikard, Aspikor, Aspinat, Aspinat Cardio, Aspinat 300, Aspirin, Aspirin Cardio, Acetylsalicylic acid, Acetylsalicylic acid-UBF, Acetylsalicylic acid tablets, Acetylsalicylic acid tablets, CardiASK, Trombosten, Trombopol, Taspir, Trombogard 100, Trombo ASS, Upsarin UPSA, etc.
Terms and conditions of storage
Store in a place inaccessible to children, at a temperature not exceeding 25 ° C.
The shelf life is 3 years. After the expiry of the shelf life indicated on the packaging, the effervescent tablets cannot be used.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Aspirin Express
On the Internet, reviews of Aspirin Express are mostly positive. Among the advantages of the drug, patients note its effectiveness (relieves pain of varying intensity, from mild and moderate to strong and not amenable to relief by other painkillers), the speed of action (it is stated that after 15-20 minutes the pain sensations pass), as well as the ability to exert an effect at the initial stage of migraine, preventing its development.
The disadvantage of Aspirin Express is considered by many to be its cost, which is quite high compared to similar drugs with a similar composition. In some reviews, users report that the tool did not help them, and also express dissatisfaction with the impressive list of contraindications and possible side effects.
The price of Aspirin Express in pharmacies
The price of Aspirin Express in pharmacy chains is 260–320 rubles. per pack with 12 effervescent tablets of 500 mg.
Aspirin Express: prices in online pharmacies
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Drug name Price Pharmacy |
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Aspirin Express 500 mg effervescent tablets for the treatment of headache 12 pcs. 279 r Buy |
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Aspirin Express tablets thorn. 500mg 12 pcs. RUB 318 Buy |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
