Antisten MV
Antisten MV: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Drug interactions
- 14. Analogs
- 15. Terms and conditions of storage
- 16. Terms of dispensing from pharmacies
- 17. Reviews
- 18. Price in pharmacies
Latin name: Antisten sr
ATX code: C01EB15
Active ingredient: Trimetazidine (Trimetazidine)
Producer: OZON LLC (Russia)
Description and photo update: 19.10.2018
Prices in pharmacies: from 308 rubles.
Buy
Antisten MV is an antihypoxic agent.
Release form and composition
Dosage form - tablets of prolonged action, film-coated: creamy pink, biconvex; on the cross section, 2 layers are visible - a creamy pink shell and a white or white core with a yellowish tinge. Tablets are packed in polymer containers of 10, 20, 30, 40, 50, 60 and 100 pcs., 1 container in a cardboard box; in blisters of 10, 20 and 30 pcs., 1, 2, 3, 4, 5, 6 or 10 packages in a cardboard box.
Active ingredient: trimetazidine dihydrochloride, 1 tablet contains 35 mg.
Additional components:
- core: microcrystalline cellulose (178.9 mg), hypromellose (93 mg), magnesium stearate (1.55 mg), colloidal silicon dioxide (1.55 mg);
- shell: Opadrai II 85F240012 Pink [polyvinyl alcohol (4 mg), titanium dioxide (2.02 mg), macrogol 3350 (2.438 mg), talc (1.48 mg), dyes iron oxide yellow (0.022 mg) and iron oxide red (0.04 mg)].
Pharmacological properties
Pharmacodynamics
Trimetazidine dihydrochloride is a substance with antihypoxic action.
The drug optimizes the metabolism and function of cardiomyocytes and neurons of the brain, exerting a direct influence on them. The cytoprotective property is due to the activation of oxidative decarboxylation, an increase in the energy potential, the rationalization of oxygen consumption (in particular, the blockade of fatty acid oxidation and increased glycolysis).
Trimetazidine maintains myocardial contractility, prevents a decrease in the intracellular level of phosphocreatinine and adenosine triphosphoric acid (ATP). Under conditions of acidosis, the drug normalizes the functioning of membrane ion channels and the intracellular content of potassium ions, prevents the accumulation of sodium and calcium ions in cardiomyocytes.
Characteristic properties of Anti-Wall MV:
- decrease in intracellular acidosis;
- decrease in the level of phosphates increased due to myocardial ischemia and reperfusion;
- maintaining the integrity of cell membranes;
- preventing the damaging action of free radicals;
- increasing the duration of the electrical potential;
- reduction in the release of the enzyme CPK (creatine phosphokinase) from the cells;
- an obstacle to the activation of granulocytic cells of neutrophils in the ischemic zone;
- weakening of the severity of ischemic myocardial damage;
- reducing the need for the use of nitrates;
- reduction in the incidence of angina attacks;
- increased resistance to physical activity (after 2 weeks of taking the drug);
- decrease in the frequency of sharp surges in blood pressure;
- reduction of dizziness and tinnitus of ischemic etiology;
- restoration of functional activity of the retina in case of vascular eye pathologies.
Pharmacokinetics
After oral administration, trimetazidine is rapidly and almost completely absorbed in the gastrointestinal tract. It is characterized by high bioavailability (about 90%). Communication with blood plasma proteins - 16%. The volume of distribution is 4.8 l / kg. The peak concentration in blood plasma is observed after 3-5 hours, a stable state - after 60 hours.
The T ½ (half-life) period is about 7 hours, in elderly patients over the age of 65 - about 12 hours. It is excreted from the body to a greater extent by the kidneys, mainly (about 60%) unchanged.
Hepatic clearance of trimetazidine decreases with age.
Renal drug clearance is directly correlated with creatinine clearance.
Trimetazidine easily penetrates histohematogenous barriers.
Indications for use
Indications for Antisten MV:
- chorioretinal vascular disorders;
- cochleovestibular disorders of an ischemic nature (tinnitus, dizziness, hearing impairment);
- prevention of angina attacks in ischemic heart disease (as part of complex therapy).
Contraindications
- age up to 18 years;
- severe liver dysfunction;
- renal failure (creatinine clearance less than 15 ml / min);
- increased individual sensitivity to drug components.
Instructions for use Antistena MV: method and dosage
Antisten MV is indicated for oral administration. It is recommended to take the tablets with meals.
Adults are prescribed 1 tablet 2 times a day (morning and evening).
The duration of treatment, depending on the clinical situation, is determined by the doctor individually.
If one or more doses are missed, it is prohibited to take a higher dose in the next dose.
Side effects
According to the instructions, Antisten MV can cause undesirable reactions, which include:
- on the part of the cardiovascular system: rarely (> 1/10 000 - <1/1000) - hot flushes to the skin of the face, orthostatic hypotension;
- from the central nervous system: often (> 1/100 - <1/10) - headache, asthenia, dizziness; very rarely (<1/10 000, including individual reports) - extrapyramidal disorders (akinesia, tremor and rigidity), reversible after drug withdrawal;
- on the part of the skin and subcutaneous fat: often - itching, skin rash, urticaria;
- from the digestive system: often - nausea, diarrhea, vomiting, abdominal pain, dyspeptic disorders.
Overdose
To date, no cases of overdose have been reported.
special instructions
Antisten MV is not intended for the relief of angina attacks, the initial course of therapy for myocardial infarction and unstable angina.
If an attack of angina pectoris develops during therapy, you should consult a doctor to review and adapt the treatment.
Influence on the ability to drive vehicles and complex mechanisms
The drug does not have a significant effect on the speed of reactions and attention.
Application during pregnancy and lactation
In studies conducted on animals, the teratogenic effect of trimetazidine has not been established, however, there are no clinical data on its safety when used during pregnancy, therefore, the possibility of the formation of malformations in the fetus cannot be completely ruled out. Antisten MV is contraindicated in pregnant women.
It has not been reliably confirmed whether trimetazidine is excreted in mother's milk or not. If it becomes necessary to prescribe the drug according to indications during lactation, you should decide with your doctor about stopping breastfeeding.
Pediatric use
Due to the fact that the safety and efficacy of trimetazidine when used before the age of 18 have not been established, Antisten MV is not prescribed in pediatrics.
With impaired renal function
Renal failure (creatinine clearance less than 15 ml / min) is a contraindication to the use of trimetazidine.
For violations of liver function
Severe liver dysfunction is a contraindication to taking the drug.
Drug interactions
No information available.
Analogs
Analogs of Antistena MV are: Triducard, Rimecor, Trimetazidin, Angiosil retard, Trimectal, Preductal MV, Trimectal MV, Deprenorm MV, Trimetazidin-Teva, Predizin, Trimetazidin MV-Teva.
Terms and conditions of storage
Shelf life is 3 years.
Keep out of the reach of children.
Storage conditions: protected from light and moisture, temperature no more than 25 ° C.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Anti-wall MV
Reviews about Antistena MV are mostly positive: the drug effectively eliminates dizziness, increased anxiety, shortness of breath and tinnitus.
The price of Antisten MV in pharmacies
The price for Antisten MV is 530-690 rubles per pack containing 60 tablets.
Antisten MV: prices in online pharmacies
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Drug name Price Pharmacy |
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Antisten MV tablets p.o. prolonged action 35mg 60 pcs. 308 RUB Buy |
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Antisten MV 35 mg film-coated tablets of prolonged action 60 pcs. 308 RUB Buy |
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Antisten MV 35 mg film-coated tablets with prolonged action, 1 + 1 combination packaging 60 pcs. 497 r Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
