Amben - Instructions For The Use Of Injections, Price, Reviews, Analogues

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Amben

Amben: instructions for use and reviews

1. 1. Release form and composition
2. 2. Pharmacological properties
3. 3. Indications for use
4. 4. Contraindications
5. 5. Method of application and dosage
6. 6. Side effects
7. 7. Overdose
8. 8. Special instructions
9. 9. Application during pregnancy and lactation
10. 10. In case of impaired renal function
11. 11. Drug interactions
12. 12. Analogs
13. 13. Terms and conditions of storage
14. 14. Terms of dispensing from pharmacies
15. 15. Reviews
16. 16. Price in pharmacies

Latin name: Amben

ATX code: B02AA03

Active ingredient: aminomethylbenzoic acid (Acidum aminomethylbenzoicum)

Producer: Pharmzashchita FSUE NPC (Russia)

Description and photo updated: 2018-26-11

Prices in pharmacies: from 3069 rubles.

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Amben - hemostatic agent; inhibitor of fibrinolysis (inhibitor of the transition of plasminogen to plasmin).

Release form and composition

Amben is produced in the form of a solution for intravenous (i / v) and intramuscular (i / m) administration / solution for i / v administration: clear colorless liquid [5 ml in an ampoule, in a blister strip (pallet) 5 ampoules, in a cardboard pack 2 contour packaging (pallets) complete with ampoule knife or without it].

Composition of 1 ml solution:

• active substance: aminomethyl benzoic acid (amben) - 10 mg;
• additional components: water for injection, sodium chloride.

Pharmacological properties

Pharmacodynamics

Amben is an inhibitor of fibrinolysis (the process of dissolving blood clots and blood clots), a synthetic analogue of lysine, with established efficacy in the treatment of bleeding of various origins. The action of the active substance is similar to the action of epsilon-aminocaproic acid, however, Amben demonstrates a much stronger effect. The specific hemostatic effect of the substance in bleeding caused by an increase in fibrinolytic activity is associated with blocking plasminogen activators and partial inhibition of the effect of plasmin.

Amben inhibits fibrinolysis by competitively saturating the lysine-binding receptors that provide the connection of plasminogen (plasmin) with fibrinogen (fibrin). The agent also inhibits biogenic kinin polypeptides.

Pharmacokinetics

Amben increases the detoxifying effect of the liver and helps to suppress antitelogenesis. When administered parenterally, the drug immediately reaches its maximum concentration in the blood and maintains this level for three hours. From the body, the agent is excreted by the kidneys, unchanged - up to 60-80%. In case of impaired renal excretory function, the concentration of the active substance in the blood increases significantly.

Indications for use

• conditions against which systemic hyperfibrinolysis occurs (including an overdose of plasminogen activators: urokinase, streptokinase, etc.);
• violations of platelet, procoagulant or vascular components of hemostasis (with a decrease in the ability to form a hemostatic thrombus);
• localized hemorrhages resulting from increased local fibrinolytic activity (during operations on the prostate, bladder, with menorrhagia, after tonsillectomy);
• surgical operations and various pathological processes, accompanied by an increase in the fibrinolytic activity of the blood; operations on the brain (including with subarachnoid hemorrhages), operations on the heart, blood vessels, lungs, pancreas and thyroid glands; uterine bleeding, premature detachment of a normally located placenta, prolonged retention of a dead fetus in the uterus; acute pancreatitis, liver disease; gastrointestinal, nosebleeds; condition after dental interventions;
• secondary hypofibrinogenemia with massive transfusions of canned blood (for prophylaxis).

Contraindications

• predisposition to thrombosis and thromboembolic lesions;
• hypercoagulable phase of disseminated intravascular coagulation (disseminated intravascular coagulation);
• severe forms of ischemic heart disease (IHD) and cerebral ischemia;
• vitreous hemorrhage;
• kidney disease leading to impaired function;
• hypersensitivity to the components of the product.

With extreme caution, Amben injections should be prescribed in the presence of cerebral circulation disorders.

Instructions for use of Amben: method and dosage

Amben is administered in doses of 50–100 mg (1–2 ampoules of a 1% solution) intravenously or intramuscularly. If necessary, it is allowed to inject multiple times at intervals of at least 4 hours. Against the background of acute fibrinolysis, it is additionally recommended to inject fibrinogen in an average dose of 2-4 thousand mg, but not more than 8 thousand mg, under the control of fibrinolytic activity and the level of fibrinogen concentration in the blood.

The maximum single dose of Amben should not exceed 100 mg (2 ampoules). The daily dose and duration of therapy are set depending on the course of the disease.

Side effects

• cardiovascular system: increase / decrease in blood pressure, tachycardia;
• digestive system: diarrhea, vomiting;
• local reactions: thrombophlebitis at the injection site;
• others: allergic reactions, catarrhal phenomena of the upper respiratory tract, renal colic.

In some cases, during the period of treatment with the agent, orthostatic hypotension, dizziness, and convulsions may occur. When these violations appear, it is required to reduce the dose or stop the administration of Amben.

Overdose

Amben's overdose was noted extremely rarely and manifested itself in the form of increased blood clotting. In this condition, intravenous heparin is prescribed at a dose of 5 thousand international units (IU) or drug therapy is canceled.

special instructions

Before prescribing a hemostatic, it is required to check the fibrinolytic activity of the blood and the content of fibrinogen. With the on / in the introduction of the solution, it is necessary to control the indicators of the coagulogram, especially in liver diseases, ischemic heart disease or after myocardial infarction.

Influence on the ability to drive vehicles and complex mechanisms

There is no information on the adverse effect of a hemostatic agent on the ability to drive vehicles and control complex and potentially dangerous mechanisms.

Application during pregnancy and lactation

In the course of preclinical studies on animals, the teratogenic effect of aminomethylbenzoic acid was not revealed.

According to the instructions, Amben is contraindicated to use in the first trimester of pregnancy, at a later date and during lactation, its use is possible only when absolutely necessary and subject to extreme caution.

With impaired renal function

In severe kidney disease, leading to impaired function, the use of the drug is contraindicated.

Drug interactions

The introduction of Amben injections can be combined with the introduction of a glucose solution, hydrolysates, anti-shock solutions.

With the simultaneous use of Amben in high doses and other hemostatic agents (for example, ethamsylate or dicinone), the risk of blood clots may increase, due to an increase in fibrin formation under the influence of hemostatics, or the antiplasmin effect of Amben, leading to a slow dissolution of the resulting blood clots.

Analogs

Amben's analogues are: Pamba, Gumbiks, Tranexam, Tugina-500, Trenax, etc.

Terms and conditions of storage

Store in a place protected from light and out of reach of children, at a temperature not exceeding 25 ° C.

The shelf life is 3 years.

Terms of dispensing from pharmacies

Dispensed by prescription.

Reviews about Amben

There are very few reviews of Amben, since the drug is intended for the provision of emergency medical care in specialized departments of the hospital. Doctors speak about the drug mostly positively, considering it an effective modern hemostatic agent that eliminates bleeding of any etiology, contributes to the patient's rapid recovery after surgery, and reduces the risk of anemia. It is noted that the drug does not lead to an increase in the prothrombin index, and also has good tolerance.

Price for Amben in pharmacies

The price of Amben solution for intravenous administration of 1% can be 3160 rubles per package containing 5 ampoules of 5 ml each.

Amben: prices in online pharmacies

Drug name Price Pharmacy

Amben 1% solution for intravenous administration 5 ml 10 pcs. RUB 3069 Buy

Anna Kozlova Medical journalist About the author

Education: Rostov State Medical University, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!