Akatinol Memantine
Akatinol Memantine: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Use in childhood
- 10. Drug interactions
- 11. Analogs
- 12. Terms and conditions of storage
- 13. Terms of dispensing from pharmacies
- 14. Reviews
- 15. Price in pharmacies
Latin name: Akatinol Memantine
ATX code: N06DX01
Active ingredient: Memantine (Memantin)
Manufacturer: Merz Pharma GmbH & Co. KGaA, Rottendorf Pharma GmbH (Germany)
Description and photo update: 2019-16-09
Prices in pharmacies: from 1418 rubles.
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Akatinol Memantine is a neurotropic treatment for dementia.
Release form and composition
According to the group affiliation, the drug belongs to muscle relaxants that act on the central nervous system.
It is produced in the form of film-coated tablets, 10 pieces in a blister strip packaging.
1 tablet contains 10 mg of the main active ingredient - memantine hydrochloride, as well as auxiliary substances:
- Lactose;
- MCC;
- Colloidal silicon dioxide;
- Talc;
- Magnesium stearate.
The shell consists of a copolymer of methacrylic acid, sodium lauryl sulfate, polysorbate 80, triacetin, simethicone emulsion, talc.
Pharmacological properties
Pharmacodynamics
Memantine is an adamantane derivative and a noncompetitive antagonist of N-methyl-D-aspartate (NDMA) receptors. It is characterized by a modulating effect on the glutamatergic system. It is responsible for the regulation of ion transport, is a blocker of calcium channels, normalizes membrane potential, activates the processes of transmission of nerve impulses. Akatinol Memantine has a positive effect on cognitive processes and enhances daily activity.
Pharmacokinetics
When taken orally, memantine is completely absorbed at a fairly high rate. Its maximum level in blood plasma is reached within 3-8 hours. With normal renal function, the accumulation of the substance in the body is not observed.
When Akatinol Memantine is taken in a daily dose of 20 mg once a day, the equilibrium plasma concentration of memantine is 70–150 ng / ml. Approximately 80% of the active ingredient of the drug is excreted unchanged. In vitro studies have shown that the metabolism, carried out with the participation of the cytochrome P450 system, is not observed. Memantine metabolites are not characterized by pharmacological activity.
The compound is excreted from the body monoexponentially, and the half-life in the terminal phase is 60–100 hours. Memantine is excreted through the kidneys. When the pH of urine is above 7, the rate of its excretion decreases.
Indications for use
The drug has a nootropic and vasodilating effect, and also stimulates the nervous system. Prevents hypoxia of the brain and the subsequent death of its cells.
The use of Akatinol Memantine is indicated for:
- Alzheimer's type dementia;
- Vascular dementia;
- Mixed dementia of all severity.
The active ingredient eliminates muscle stiffness and bradykinesia (lack of mobility), improves memory and concentration, increases physical endurance and relieves symptoms of depression, and reduces the tendency to muscle spasms caused by brain diseases.
Contraindications
According to the instructions, Akatinol Memantine is contraindicated in:
- Individual intolerance to any components of the drug;
- Acute dysfunctions of the brain;
- Epilepsy;
- Thyrotoxicosis;
- Renal or hepatic impairment;
- Pregnancy and breastfeeding.
Instructions for the use of Akatinol Memantine: method and dosage
For adults, the drug is taken from 5 mg / day. After 1 week, the dose can be increased to 10 mg / day, and during the 3rd week, 20 mg / day is prescribed.
The maintenance dose ranges from 10-20 mg / day. The maximum allowable dose of Akatinol Memantine is 30 mg / day. It is recommended to start treatment with the appointment of the minimum effective doses, which are set individually.
Side effects
The drug can cause the following side effects:
- Dizziness;
- Excessive excitability;
- Nausea;
- Asthenia (weakness);
- Anxiety;
- Intracranial hypertension.
Overdose
An overdose of Akatinol Memantine is most often manifested by an increase in the intensity of adverse reactions. In this case, the stomach is washed and activated charcoal is prescribed, and symptomatic therapy is also carried out.
special instructions
When taken simultaneously with barbiturates, antipsychotic or anticholinergic medications, their effect may be enhanced.
The use of Akatinol Memantine can contribute to a change in the rate of reactions, therefore, patients who are treated on an outpatient basis should be careful when driving vehicles and complex mechanisms.
Pediatric use
According to the instructions, Akatinol Memantine is not prescribed for children under 18 years of age.
Drug interactions
When Akatinol Memantine is combined with anticholinergics, dopamine agonists, L-dopa drugs, the latter may increase. Taking the drug together with antipsychotics and barbiturates can reduce the effectiveness of the latter. The combination of Akatinol Memantine with batrafen or dantrolene can change (reduce or enhance) the effect of these drugs, so an individual dose adjustment will be required.
The drug is incompatible with dextromethophan, ketamine and amantadine, so their simultaneous use is strictly prohibited.
The combined use of Akatinol Memantine and nicotine, cimetidine, quinine, quinidine and procainamide can lead to an increase in the concentration of the latter in plasma. Hydrochlorothiazide, taken together with memantine, can be found in plasma at lower concentrations than usual.
Analogs
Memantine contains the following drugs:
- Alzeim;
- Memaneirin;
- Memantine;
- Memantal;
- Memantinol.
The analogs of Akatinol Memantine in terms of the mechanism of action are:
- Bilobil;
- Vitrum Memori;
- Gingium;
- Ginos;
- Intellan;
- Memoplant;
- Tanakan.
Terms and conditions of storage
Store in a dry, dark place at a temperature not exceeding 25 ° C. Keep out of the reach of children.
Shelf life is 4 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Akatinol Memantine
There are various reviews about Akatinol Memantine: both positive and negative. For elderly patients diagnosed with Alzheimer's disease or another variant of dementia, the drug is considered indispensable. However, it should be understood that he is only able to slow down the development of the disease and slightly improve the general well-being of the patient. To date, drugs that completely relieve a person from such diseases have not yet been found, and Akatinol Memantine is no exception. Many patients also dislike the very high price of the drug.
Sometimes a drug is prescribed to children in order to improve their mental development, despite the fact that the drug is contraindicated for this category of patients in accordance with the instructions. Reviews about him when used for these purposes range from enthusiastic to sharply negative. Many parents argue that the initially positive influence on the child is often replaced by a sharp regression, which returns the little patient to his original state or even worsens it. Therefore, the decision to use Akatinol Memantine in children should be made after consultation with a specialist and with the full understanding of the parents of the possible consequences.
The price of Akatinol Memantine in pharmacies
The approximate price for Akatinol Memantine with a dosage of 10 mg is 1568-1750 rubles (for a pack of 30 tablets) or 4397-4897 rubles (for a pack of 90 tablets).
Akatinol Memantine: prices in online pharmacies
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Drug name Price Pharmacy |
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Akatinol Memantine 10 mg film-coated tablets 30 pcs. 1418 RUB Buy |
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Akatinol memantine tablets p.o. 10mg 30 pcs. 1458 RUB Buy |
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Akatinol Memantine 20 mg film-coated tablets 28 pcs. 2204 RUB Buy |
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Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
